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Interfacial Engineering with a Nanoparticle-Decorated Porous Carbon Structure on β″-Alumina Solid-State Electrolytes for Molten Sodium Batteries
Published 2022“…Heat treating a simple slurry, composed only of water, acetone, carbon black, and lead acetate, formed a porous carbon network decorated with PbO<sub><i>x</i></sub> (0 ≤ <i>x</i> ≤ 2) nanoparticles between 10 and 50 nm. Extensive performance analysis, through impedance spectroscopy and symmetric cycling, shows a stable, low-resistance interface for close to 6000 cycles. …”
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Interfacial Engineering with a Nanoparticle-Decorated Porous Carbon Structure on β″-Alumina Solid-State Electrolytes for Molten Sodium Batteries
Published 2022“…Heat treating a simple slurry, composed only of water, acetone, carbon black, and lead acetate, formed a porous carbon network decorated with PbO<sub><i>x</i></sub> (0 ≤ <i>x</i> ≤ 2) nanoparticles between 10 and 50 nm. Extensive performance analysis, through impedance spectroscopy and symmetric cycling, shows a stable, low-resistance interface for close to 6000 cycles. …”
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169
Interfacial Engineering with a Nanoparticle-Decorated Porous Carbon Structure on β″-Alumina Solid-State Electrolytes for Molten Sodium Batteries
Published 2022“…Heat treating a simple slurry, composed only of water, acetone, carbon black, and lead acetate, formed a porous carbon network decorated with PbO<sub><i>x</i></sub> (0 ≤ <i>x</i> ≤ 2) nanoparticles between 10 and 50 nm. Extensive performance analysis, through impedance spectroscopy and symmetric cycling, shows a stable, low-resistance interface for close to 6000 cycles. …”
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3‑Hydroxyquinolin-2-Ones Act as Dual Inhibitors of Ferroptosis and Monoamine Oxidase B: Reducing Alzheimer’s Disease-Related Amyloid Precursor Protein and Hyperphosphorylated Tau I...
Published 2025“…Additionally, overexpression of monoamine oxidase B (MAO-B) induces oxidative stress and decreases cognitive function. In this study, we presented the novel dual inhibitors of ferroptosis and MAO-B for AD management, aiming to address both the symptomatic and neurodegenerative aspects of this disease. …”
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171
Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes
Published 2022“…Mammalian STE20-like protein 1 kinase (MST1) plays vital roles in the apoptosis and insulin secretion of β cells. Here, we discovered a novel, potent, and selective MST1 inhibitor <b>19</b> (IC<sub>50</sub> = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. …”
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172
Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes
Published 2022“…Mammalian STE20-like protein 1 kinase (MST1) plays vital roles in the apoptosis and insulin secretion of β cells. Here, we discovered a novel, potent, and selective MST1 inhibitor <b>19</b> (IC<sub>50</sub> = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. …”
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
Published 2021“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
Published 2021“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”
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High resolution structures visible with the 25 nm zone plate objective.
Published 2022“…<p>139 CryoSXT tomograms were recorded from 107 cells using a 25 nm zone plate objective and several structures that were unrelated to HSV-1 infection were observed, including some that were not visible using the 40 nm zone plate objective. …”
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DataSheet_1_Interventions to Decrease Carotid-Intima Media Thickness in Children and Adolescents With Type 1 Diabetes: A Systematic Review and Meta-Analysis.docx
Published 2022“…</p>Conclusions<p>Some pharmacological interventions may decrease CIMT in children with type 1 diabetes. However, there is great uncertainty with respect to their effects and no strong conclusions can be drawn. …”
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