SMO inhibits PKA substrate phosphorylation in a G protein–independent manner. by Corvin D. Arveseth (10688311)

“…<p>(<b>A</b>) Schematic of assay to report PKA activity toward soluble substrates. …”

Aging in Mouse Brain Is a Cell/Tissue-Level Phenomenon Exacerbated by Proteasome Loss by Lei Mao (51012)

“…We observed a near-linear decrease of protein redundancy during aging. …”

Aging in Mouse Brain Is a Cell/Tissue-Level Phenomenon Exacerbated by Proteasome Loss by Lei Mao (51012)

“…We observed a near-linear decrease of protein redundancy during aging. …”

Aging in Mouse Brain Is a Cell/Tissue-Level Phenomenon Exacerbated by Proteasome Loss by Lei Mao (51012)

“…We observed a near-linear decrease of protein redundancy during aging. …”

Differential gene expression in Huh-7 cells and PHH resulting from treatment with THR agonists. by Xuan G. Luong (9761423)

BPA is a blocker of human heart sodium channels (hNav1.5). by Andrias O. O’Reilly (148537)

“…<p>A: Dose response curve of tonic block of hNav1.5 by BPA is shown as the relative decrease of sodium current response to a square voltage step to −10 mV (see inset) at various concentrations of BPA from a V_hold of −120 mV (green circles) or −90 mV (blue circles). …”

The optimal asset allocation between the S&P500 index and a risk-free asset as a function of the risk-free interest rate <i>r</i>_<i>f</i>. by Haim Levy (252011)

“…In contrast, for an investor with a logarithmic utility function (thin line) the optimal allocation to the stock decreases gradually with the risk-free rate (note that the allocation is bounded between 0% and 100%, as no borrowing or short-selling are allowed).…”

FoxO1a is induced by CD81 clustering, concurrent with deactivation of Akt. by Kuanyin K. Lin (200312)

“…<p>(A) The phosphorylation of Akt, an indicator of Akt activation, decreases upon CD81 clustering on proliferating HSCs. …”

How Cheap Is Soaring Flight in Raptors? A Preliminary Investigation in Freely-Flying Vultures by Olivier Duriez (290803)

“…Weather conditions influenced flight performance and HR was noticeably higher during cloudy compared to sunny conditions when prolonged soaring flight is made easier by thermal ascending air currents. Soaring as a cheap locomotory mode is a crucial adaptation for vultures who spend so long on the wing for wide-ranging movements to find food.…”

Cyclin G2 is a target molecule of Cn/NFATc2 in follicular keratinocytes. by Atsushi Fujimura (227683)

“…<p>(A) The microarray analysis identified 24 genes that showed down-regulated expression in PHK cells treated with either 11R-VIVIT or CsA; <i>ccng2</i> (cyclin G2) expression showed the greatest decrease after Cn/NFAT inhibition. …”

Temporal Sensitivity of Protein Kinase A Activation in Late-Phase Long Term Potentiation by MyungSook Kim (65534)

“…Examination of CaMKII reveals that its temporal sensitivity is opposite that of PKA, suggesting that PKA is required after spaced stimulation to compensate for a decrease in CaMKII. In addition to explaining the temporal sensitivity of PKA, these simulations suggest that the use of several kinases for memory storage allows each to respond optimally to different temporal patterns.…”

Modulation of HS α4β2 receptors with a low concentration of arecoline. by Roger L. Papke (685990)

“…<p>(A) Partial agonists for α4β2 nAChR such as varenicline and cytisine [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140907#pone.0140907.ref035" target="_blank">35</a>] modulate the sensitivity of the receptors to the endogenous activator ACh through pre-desensitization for prolonged periods, even when present at very low concentrations. …”

SIRT1 preserves dendritic integrity in hippocampal neurons challenged with Aβ fibrils. by Juan F. Codocedo (304388)

“…Treatment with Aβ fibrils significantly decrease the number of intersection at 28–110 µm from the soma compared with GFP transfected neurons (p<0,01 at 28–100 µm). …”

Antioxidant Carbocysteine Treatment in Obstructive Sleep Apnea Syndrome: A Randomized Clinical Trial by Kang Wu (160544)

“…The CPAP group also showed a decreased oxygen desaturation index and a significant increase in the mean oxygen saturation after treatment, but these increases were not observed in the carbocysteine group. …”

The role of RGS5^high VSMC subpopulation during vascular remodeling. by Ya-Kun Gao (12280161)

An idealized view of the opportunity provided by a comparative and integrated oncology drug development path. by Ira Gordon (369869)

“…<p>This is a theoretical illustration of 100 preclinical agents that may be evaluated by either a conventional or an integrated and comparative drug development path. …”

Daily and annual fractional global area with rainfall from the ERA5 reanalysis. by Rasmus E. Benestad (12530330)

“…<p>The blue curve represents the rainfall area between 50°S and 50°N. The thick curves show the annual mean <i>A</i>_<i>p</i> estimated from daily estimates. …”

M1 polarization of macrophages upon persistent exposure to androgen. by Qin Lang (2902367)

“…(B, C, and D) Upon stimulation of RAW 264.7 cells with T, the mRNA expression levels of IL-12, iNOS and IL-6, and IL-1β increased significantly on day-1, 2, and 3, respectively, whereas (E, F, G) IL-10 and Arg1 expressions decreased significantly on day-3 (treatment with three T doses at the same time point, *<i>P</i><0.05 and **<i>P</i><0.01 by one-way ANOVA; group treated with 0 nM T versus group treated with 10 nM T, ^#<i>P</i><0.05 and ^##<i>P</i><0.01 by Dunnett’s multiple comparison test; group treated with 0 nM T versus group treated with 100 nM T, ^&<i>P</i><0.05 and ^&&<i>P</i><0.01 by Dunnett’s multiple comparison test).…”

Histological changes of the vasoactive markers in the thoracic aorta. by Bálint Bányai (16384614)

Melatonin alleviates tomato plant damage induced by PEG6000 simulated drought treatment. by Lu Yang (30847)