The Catalytic Subunit of the System L1 Amino Acid Transporter (<i>Slc7a5</i>) Facilitates Nutrient Signalling in Mouse Skeletal Muscle by Nadège Poncet (527942)

“…These changes were associated with >50% decrease in S6K Thr389 phosphorylation in muscles from MS-<i>Slc7a5</i>-KO mice, indicating reduced mTOR-S6K pathway activation, despite no significant differences in lean tissue mass between groups on the same diet. …”

DataSheet_1_Identifying hub genes in response to ustekinumab and the impact of ustekinumab treatment on fibrosis in Crohn’s disease.zip by Ying Xu (9172)

“…Introduction<p>Crohn’s disease (CD) is a chronic inflammatory disease. Approximately 50% of patients with CD progressed from inflammation to fibrosis. …”

Presentation_1_Selective Heart Irradiation Induces Cardiac Overexpression of the Pro-hypertrophic miR-212.PPTX by Márta Sárközy (757337)

“…In contrast, the total FOXO3 protein level failed to decrease in response to heart irradiation at week 19. …”

Table_1_Narrowing row spacing and adding inter-block promote the grain filling and flag leaf photosynthetic rate of wheat under enlarged drip tube spacing system.xlsx by Jianguo Jing (18767383)

“…The decline of NS22 (9.93%) was higher than that of NS44 (9.04%), and both cultivars also showed a greater decrease in grain weight and average grain-filling rate (AGFR) of inferior grains (NS22: 23.19%, 13.97%; NS44: 7.78%, 5.86%) than the superior grains (NS22: 10.60%, 8.33%; NS44: 4.89%, 4.62%). …”

DataSheet_1_Narrowing row spacing and adding inter-block promote the grain filling and flag leaf photosynthetic rate of wheat under enlarged drip tube spacing system.zip by Jianguo Jing (18767383)

“…The decline of NS22 (9.93%) was higher than that of NS44 (9.04%), and both cultivars also showed a greater decrease in grain weight and average grain-filling rate (AGFR) of inferior grains (NS22: 23.19%, 13.97%; NS44: 7.78%, 5.86%) than the superior grains (NS22: 10.60%, 8.33%; NS44: 4.89%, 4.62%). …”

DataSheet_1_A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection.... by Savannah M. Rocha (10826524)

“…Animals were infected intranasally with 2.5 × 10⁴ TCID₅₀/ml equivalents of SARS-CoV-2 (strain 2019-nCoV/USA-WA1/2020) and PT150 was administered by oral gavage at 30 and 100 mg/Kg/day for a total of 7 days. …”

Table1_Clinical efficacy and safety of adjunctive treatment of chronic ischemic heart failure with Qishen Yiqi dropping pills: a systematic review and meta-analysis.docx by Wang Xingmeng (17662179)

“…The quality of the literature was assessed according to the Cochrane Reviewers' Handbook 5.0 and the Modified Jadad Scale (with a score of 4–7 rated as high quality). …”

An explanation of the pRF dynamics in terms of feedback signals from extrastriate cortex. by Koen V. Haak (321925)

“…Interestingly, this model also predicts that increasing the size of the mask (shifting the fringe to the right) results in a decrease of the pRF expansion. This is indeed what appears to happen when the mask size increases from 5.0° to 7.5° (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037686#pone-0037686-g004" target="_blank">Figure 4B</a> and corresponding text).…”

DataSheet_1_Clinicopathologic and Genomic Features in Triple-Negative Breast Cancer Between Special and No-Special Morphologic Pattern.docx by Ying-Zi Li (12291221)

“…The most commonly altered genes were TP53 (88.7%), PIK3CA (26.8%), MYC (18.3%) in NSTs, and TP53 (68.8%), PIK3CA (50%), JAK3 (18.8%), KMT2C (18.8%) in STs respectively. …”

Image1_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulatio... by Sujuan Wang (1865149)

“…In contrast, the expression of TGF-β₁, TLR4, and MyD88, as well as the p-P65/P65 and p-IκBα/IκBα ratios, were considerably reduced following TFPCP treatment. In addition, we identified 32 metabolites exhibiting differential abundance in the Model group. …”

Swimming endurance training protocol. by Vítor S. Fernandes (21262991)

“…This study aimed to investigate the effect of <i>MIB1</i> mutations on cardiac electrical activity. We examined male <i>Mib1</i>^<i>flox</i><i>;Tnnt2</i>^<i>Cre</i> mice, a disease model of LVNC, and wildtype littermates on the C57BL/6J genetic background. …”

Image2_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulatio... by Sujuan Wang (1865149)

“…In contrast, the expression of TGF-β₁, TLR4, and MyD88, as well as the p-P65/P65 and p-IκBα/IκBα ratios, were considerably reduced following TFPCP treatment. In addition, we identified 32 metabolites exhibiting differential abundance in the Model group. …”

Interface Engineering Modulation Combined with Electronic Structure Modification of Zn-Doped NiO Heterostructure for Efficient Water-Splitting Activity by Gundegowda Kalligowdanadoddi Kiran (17654768)

“…In a full-cell water-splitting device, the vacuum-synthesized ZnNiO heterostructure demonstrates a cell voltage of 1.94 V at 50 mA cm^–2 and shows remarkable stability over 24 h at a high current density of 100 mA cm^–2. …”

Data_Sheet_1_Ribozyme-Mediated Downregulation Uncovers DNA Integrity Scanning Protein A (DisA) as a Solventogenesis Determinant in Clostridium beijerinckii.pdf by Victor Chinomso Ujor (10939044)

“…To relieve CCR in Clostridium beijerinckii NCIMB 8052, we sought to downregulate catabolite control protein A (CcpA) using the M1GS ribozyme technology. …”

Image_1_Archetypal type II and III Toxoplasma gondii oocysts induce different immune responses and clinical outcomes in experimentally infected piglets.tif by Andrea Largo-de la Torre (13985607)

“…Apathy and a moderate decrease in feed consumption were observed in G1 and G2 piglets between 5 and 8 dpi, coinciding with fever (>40°C). …”

The impact of improved detection and treatment of isoniazid resistant tuberculosis on prevalence of multi-drug resistant tuberculosis: A modelling study by Kamila Romanowski (6260870)

“…</p><p>Conclusion</p><p>Accurate diagnosis and tailored treatment of INHR-TB with LPA led to an almost 50% relative decrease in acquired MDR-TB when compared with an Xpert MTB/RIF strategy. …”

Short and Long-Term Effects of the Angiotensin II Receptor Blocker Irbesartan on Intradialytic Central Hemodynamics: A Randomized Double-Blind Placebo-Controlled One-Year Intervent... by Christian Daugaard Peters (748219)

“…Mean start and mean end cardiac output, stroke volume, total peripheral resistance, heart rate, and mean arterial pressure were stable and similar in the two groups, whereas central blood volume increased slightly but similarly over time. …”

Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): A multicentre, open-label, randomised controlled trial by Piero Ruscitti (3684799)

“…Participants in the TNFi group had a nonsignificant slight decrease of HbA1c%. Assuming the success threshold to be HbA1c% ≤ 7, we considered an absolute risk reduction (ARR) = 0.42 (experimental event rate = 0.54, control event rate = 0.12); thus, we estimated, rounding up, a number needed to treat (NNT) = 3. …”

Threshold level of Δ<em>T</em>_g leading to significant local changes in water resources (a) and terrestrial ecosystems (b) by Dieter Gerten (557088)

“…All values denote changes found in >50% of the simulations.</p> <p><strong>Abstract</strong></p> <p>This modelling study demonstrates at what level of global mean temperature rise (Δ<em>T</em>_g) regions will be exposed to significant decreases of freshwater availability and changes to terrestrial ecosystems. …”

Simulated exposure of world population to water scarcity (a) and of global endemism richness to severe habitat changes (b), plotted as functions of Δ<em>T</em>_g by Dieter Gerten (557088)

“…</p> <p><strong>Abstract</strong></p> <p>This modelling study demonstrates at what level of global mean temperature rise (Δ<em>T</em>_g) regions will be exposed to significant decreases of freshwater availability and changes to terrestrial ecosystems. …”