Image11_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image10_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

MMP3 induced mitochondrial ROS regulate the Nox1 expression in 6-OHDA treated N27 cells. by Dong-Hee Choi (617376)

“…Apo: apocynin, a Nox inhibitor; GKT: GKT137831, a Nox1 selective inhibitor; AA, antimycin A (100 µM); FCCP, an oxidative phosphorylation uncoupler (100 nM), Results are presented as the mean ± SEM, n = 8. ** p<0.01, ***p<0.001 vs. nontreated control; # p<0.05, ## p<0.01, ### p<0.001 vs. 6-OHDA control. …”

Gal-3 is upregulated in hypoxia in NG97ht cells. by Rafael Yamashita Ikemori (698128)

“…In the treatment of the protein extracts with AP, there was a decrease in isoforms 2 and 3 compared to control samples mainly in cells exposed to normoxia. …”

IL-1Ra treatment does not alter EDL muscle force. by Margaret E. Benny Klimek (2805361)

Effect of T/HS without or with IL-6 treatment on the liver inflammation transcriptome; impact of Stat3 inhibition on the IL-6 effect. by Ana Moran (80716)

“…The expression of 84 of 100 of these genes was decreased in the SBR50/IL-6 vs. …”

<i>Theileria annulata</i> parasites with M128I mutation in cytochrome B (<i>Ta</i>M128I) resist buparvaquone treatment. by Shahin Tajeri (3609266)

“…<p><b>(A)</b> Proliferation dose-response curves of wild type and <i>Ta</i>M128I containing macrophages treated for 72 h with 1, 10, 100, 1000 and 10000 nM BPQ. …”

Effects of STAT3 decoy oligonucleotide on the proliferation, apoptosis, and migration of HUVECs and HDMECs<i>in vitro</i>. by Jonah D. Klein (505754)

“…<p>(A) HUVECs and (B) HDMECs were transfected with the STAT3 decoy oligonucleotide or mutant control oligonucleotide at 0 nM to 1000 nM. …”

Evidence for constitutive activation of cytoprotective enzymes network in vitiligo melanocyte cultures. by Barbara Bellei (177809)

“…<p>(A) Total RNA was extracted from eleven vitiligo and fifteen normal melanocyte cell cultures. …”

Simultaneous increase in canonical Wnt signaling and suppression of pAKT result in increased apoptosis of CC cells. by Michael Bordonaro (340595)

“…Cells were exposed for 8 or 17 hrs to mock treatment (M), 5 mM butyrate (B), butyrate and 5 µM MK2206 (BMK), 100 nm LBH589 (L), or 100 nm LBH589 and 5 µM MK2206 (LMK). …”

Table_2_Potentially differential impacts on niche overlap between Chinese endangered Zelkova schneideriana and its associated tree species under climate change.docx by Yanrong Zhou (4841061)

“…The most important factor influencing its population distribution was Min temperature of coldest month (Bio6), followed by Mean diurnal range (Bio2), with the total contribution of 78.9%. (2) Currently, the suitable area of Z. schneideriana was predicted to be 106.50 × 10⁴ km², mostly located in the subtropical region of China, especially in Anhui, Hubei, Hunan, Jiangsu, and Zhejiang provinces. (3) Its suitable area would decrease and its average migration distance was 19.72 km under 16 future climate scenarios, with the core distribution migrating northeast. (4) There is an asynchrony of potential niche overlap between species pairs. …”

Influence of dietary and physical activity restriction on pediatric adenotonsillectomy postoperative care in Brazil: a randomized clinical trial by Denise Manica (4702840)

“…Parameters were compared at the 3rd and at the 7th postoperative day between intervention groups. Results We have enrolled a total of 95 patients, 50 in Group A and 45 in Group B. …”

Data_Sheet_1_Efficacy and Safety of Remimazolam for Procedural Sedation: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis.docx by Bo-Jyun Jhuang (11187882)

“…Compared with the use of midazolam, the utilization of remimazolam resulted in an increase in procedure success rate [odds ratio (OR) = 9.01, 95% confidence interval (CI): 2.35–34.57], a reduction in the application of rescue medication (OR = 13.58, 95% CI: 3.46–53.28), a decrease in time to recovery [minutes, weighted mean difference (WMD) = −5.70, 95% CI: −8.68 to −2.72], and a better cognitive recovery of Hopkins Verbal Learning Test-Revised (WMD = 5.22, 95% CI: 2.88–7.55). …”

Table_1_Potentially differential impacts on niche overlap between Chinese endangered Zelkova schneideriana and its associated tree species under climate change.docx by Yanrong Zhou (4841061)

“…The most important factor influencing its population distribution was Min temperature of coldest month (Bio6), followed by Mean diurnal range (Bio2), with the total contribution of 78.9%. (2) Currently, the suitable area of Z. schneideriana was predicted to be 106.50 × 10⁴ km², mostly located in the subtropical region of China, especially in Anhui, Hubei, Hunan, Jiangsu, and Zhejiang provinces. (3) Its suitable area would decrease and its average migration distance was 19.72 km under 16 future climate scenarios, with the core distribution migrating northeast. (4) There is an asynchrony of potential niche overlap between species pairs. …”

Pre-operative platelet reactivity is a strong, independent predictor of bleeding complications after branched endovascular thoracoabdominal aortic aneurysm repair by Aleksandra Gąsecka (11241457)

“…The effect of EVAR on platelet reactivity is unknown. We prospectively determined the effect of branched EVAR (bEVAR) on platelet reactivity in patients with TAAA, and evaluated the predictive value of preoperative platelet reactivity for post-operative bleeding in 50 consecutive patients undergoing elective bEVAR (mean age 70.9 ± 5.7 years, 66% male). …”

Effectiveness of milking management practices for SCC and TBC levels in milk by Marina Oliveira Daneluz (5670299)

“…For such, the quantile regression method was used to estimate models for the 10th, 50th, and 90th quantiles. The results confirmed that SCC and TBC levels decrease as the number of practices increases. …”

Uniform downscaling of postsynaptic AMPA receptors across the dendritic tree in primary hippocampal cultures. by Mathieu Letellier (6803699)

“…(B) Representative EPSC trace evoked by a pair of brief depolarizations (+100 mV, 50-ms interval) of the presynaptic neuron. …”

Supplementary Material for: The impact of age and body composition on the agreement between estimated and measured GFR in heart transplant recipients by Hornum M. (16418109)

“…During the first year after HTx, mean weight increased by 4.2 kg (CI:3.2–5.1) followed by an annual decrease of 0.35 kg/year (Cl:-0.05–0.74). mGFR increased by 7.5 ml/min (Cl:3.2–11.8) the first year but was stable hereafter (0.0 ml/min/year CI:-1.0–1.0). …”

Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies by Hadith Tangestani (6202022)

“…VDFs may increase serum 25(OH)D and BMD while decrease serum PTH levels. We did not find any beneficial effect of VDFs on BTM.…”

Reduction in testis size and near complete absence of mature spermatozoa in GC-Dcr1 and GC-Dgcr8 mutant mice. by Céline Zimmermann (558274)

“…<p>(A–C, M) At P60, testis weight showed a 55% and 50% reduction in GC-Dcr1 (n = 16) and GC-Dgcr8 mutants (n = 5) compared to control testes (n = 17). …”