QLT-0267 Increases Nuclear Area and Multinucleated Cells in a Concentration-Dependent Manner. by William K. A. Sikkema (574881)

“…The proportion of cells having a nuclear area up to and including 100 (0–100), <100≤150 (100–150), <150≤200 (150–200), <200≤250 (200–250) and >250 (250+) was determined for the controls and cells treated with 15–25 µM QLT-0267.…”

Predictors of Visceral Leishmaniasis Relapse in HIV-Infected Patients: A Systematic Review by Gláucia F. Cota (218288)

“…Two studies found that baseline CD4+ T cell count above 100 cells/mL was associated with a decreased relapse rate. …”

Patients outcome. by Loïc Duron (6433634)

“…Reliance on temporal-artery biopsy fell (17% vs 91%; p < 0.01), owing to a four-fold rise in diagnostic MRI use. Mean total medical costs decreased by €814 per patient (€3672 ± 2861 vs €4486 ± 3193), although this difference did not reach statistical significance (p = 0.23).…”

Primers for qPCR. by Kaitao Zhao (3617825)

“…Results revealed the MRE11–RAD50–NBS1 (MRN) complex as a potential factor. Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

Antibodies used for western blotting. by Kaitao Zhao (3617825)

“…Results revealed the MRE11–RAD50–NBS1 (MRN) complex as a potential factor. Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

Target sequences of siRNAs. by Kaitao Zhao (3617825)

“…Results revealed the MRE11–RAD50–NBS1 (MRN) complex as a potential factor. Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

Plasmids information. by Kaitao Zhao (3617825)

“…Results revealed the MRE11–RAD50–NBS1 (MRN) complex as a potential factor. Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

Raw data. by Kaitao Zhao (3617825)

“…Results revealed the MRE11–RAD50–NBS1 (MRN) complex as a potential factor. Transiently or stably knockdown of MRE11, RAD50 or NBS1 in hepatocytes before HBV infection significantly decreased viral markers, including cccDNA, while reconstitution reversed the effect. …”

The mechanism for pattern convergence and divergence requires a high-threshold transfer function. by Gaia Tavoni (5451656)

“…Low cortical activation thresholds yield effects that are qualitatively different from the realistic high-threshold case. (<b>A</b>) Analytical results obtained for <i>θ</i>_<i>c</i> = 0.35 and the feedback scenarios of <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009479#pcbi.1009479.g002" target="_blank">Fig 2A and 2B</a>: red indicates 100% excitatory feedback for both odors; blue indicates 100% excitatory/inhibitory feedback for the first/second odor, respectively. …”

Data_Sheet_1_Functional characterization of Vibrio alginolyticus T3SS regulator ExsA and evaluation of its mutant as a live attenuated vaccine candidate in zebrafish (Danio rerio)... by Weijie Zhang (145595)

“…Besides, the ΔexsA showed a weakened swarming phenotype and an ~100-fold decrease in virulence to zebrafish. …”

Usage of a Localised Microflow Device to Show that Mitochondrial Networks Are Not Extensive in Skeletal Muscle Fibres by Joseph Bruton (635407)

“…Cytosolic free [Ca²⁺] was monitored with fluo-3. A pulse of carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP, 100 µM) applied to a small area of the muscle fibre (30 µm in diameter) produced a rapid decrease in the mitochondrial TMRE signal (indicative of depolarization) to 38% of its initial value. …”

Cost-effectiveness of maternal influenza immunization in Bamako, Mali: A decision analysis by Evan W. Orenstein (130613)

“…<div><p>Background</p><p>Maternal influenza immunization has gained traction as a strategy to diminish maternal and neonatal mortality. …”

Inducible knockdown of a gene essential for cortical development impaired radial migration. by Tokuichi Iguchi (178202)

“…<p>(A) Immunoblot analysis of the inducible knockdown against the exogenously expressed Dab1 in HEK293T cells. …”

Effects of <i>A. ilicifolius</i> on histological sections of AOM-induced ACF. by Amel A. Almagrami (562558)

“…(D) 250 mg/kg A. ilicifolius + AOM showed elongated ACF and nuclei, slight decreases in goblet cells and nuclei showed slightly nuclear stratification (E) 500 mg/kg A. ilicifolius + AOM showed ACF with slightly rounded shape and without stratified nuclei, slightly decreased in number of goblet cells and proliferation of nuclei (H & E stain 100×).…”

Quantification of silica-induced apoptosis in the lungs of the ApoA1 transgenic mice. by Eun hee Lee (280913)

“…<p>(<i>A)</i> Immunoblot analysis showed that active form of caspase-3 protein expression was significantly decreased in the ApoA1_D7 and D15 groups compared with the Silica group. …”

Oxidized Nm23 is a substrate of NADPH-TrxR-Trx system. by Eunsun Lee (256928)

“…<p>(A) Suggested scheme of oxido-reduction regulation of Nm23-H1 by TrxR-Trx-NADPH system. …”

Implementation and first experiences with a multimodal mentorship curriculum for medicine-paediatrics residents by Lao-Tzu Allan-Blitz (12073783)

“…Residents reported consistently high satisfaction with peer mentorship (77.8%–100%). The percent of residents reporting they had identified a career mentor increased from 60.0% in 2017 to 88.9% in 2019, which was sustained at 90.0% in 2020.…”

Erythroid/Gata1 precursors are affected by <i>csrnp1a</i> knockdown. by Jaime Espina (106906)

“…At 8 somite stage the expression of the erythroid marker <i>klf4</i> was not affected in morphant embryos (A, B) (100%, n = 48). However a clear decrease in <i>gata1</i> expression was detected in <i>csrnp1a</i> deficient embryos (compare C with D) (54,8%; n = 23/42) without major changes in the number of <i>myoD</i> stripes (7,1%; n = 3/42, more than 2 stripes), which served as readout of developmental progression. …”

RPMA data presented as a diagram of signaling events in HSAECs infected with RVFV. by Taissia G. Popova (226544)

“…Consistent with this, the level of apoptosis inhibitor XIAP100 was decreased. The intrinsic apoptotic pathway marker, caspase-9, demonstrated only a marginal activation accompanied by increased level of the inhibitor of apoptosome formation, HSP27.…”

Imatinib causes a reduction in the size of granulomatous lesions in Mm-infected mice. by Tesia L. Cleverley (15628353)

“…<p><b>A-C.</b> Bacterial load in the spleen, tail, and lung of mice infected with 2x10⁶ CFU of Mm and treated with 100mg/kg/day imatinib via osmotic pump starting day -1, day 7, or day 14 for a total infection period of 6 days <b>(A)</b>, 14 days <b>(B)</b>, and 21 days <b>(C)</b>. …”