Data_Sheet_1_Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Act... by Sourya Bhattacharya (8441028)

“…A significant decrease in melting temperature (BlaC T_M 60°C, S130A T_M 50°C, and S130G T_M 45°C), kinetic instability at higher temperature, and comparative dynamic instability correlate the fact that resistance to beta-lactam/beta-lactamase inhibitor combinations will likely not arise from the structural alteration of BlaC, therefore establishing confidence that this therapeutic modality can be potentially applied as a part of a successful treatment regimen against M. tuberculosis.…”

Microbial Alliances: Unveiling the Effects of a Bacterial and Fungal Cross-Kingdom SynCom on Bacterial Dynamics, Rhizosphere Metabolites, and Soybean Resilience in Acidic Soils by Zhongling Wen (13878743)

“…Acidic soils, covering 40 to 50% of arable land, hinder productivity due to phosphorus limitation and aluminum toxicity. …”

Data_Sheet_1_The burden of epilepsy in the People’s Republic of China from 1990 to 2019: epidemiological trends and comparison with the global burden of epilepsy.PDF by Yun Shu (2016445)

“…However, Disability-Adjusted Life Years (DALY) decreased notably, and the proportion of Years of Life Lost (YLL) decreased from 62.73 to 39.03%. …”

Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic <i>in utero</i> by Andres Cardenas (731479)

“…A doubling in toenail mercury concentration was associated with a 2.5% decrease (95% CI: 5.0%, 1.0%) in the estimated monocyte proportion. …”

Supplementary Material for: Different Roles of Functional and Structural Renal Markers Measured at Discontinuation of Renal Replacement Therapy for Acute Kidney Injury by Yoshida T. (2879729)

“…Introduction: Severe acute kidney injury (AKI) requiring renal replacement therapy (RRT) has been associated with an unacceptably high mortality of 50% or more. Successful discontinuation of RRT is thought to be linked to better outcomes. …”

Data_Sheet_2_Patient satisfaction and outcomes of crisis resolution home treatment for the management of acute psychiatric crises: a study during the COVID-19 pandemic in Madrid.do... by Irene Moreno-Alonso (16931331)

“…However, CRHT did not achieve a statistically significant decrease in caregiver burden. Regarding the satisfaction of the patients with the attention and care received, an average score of 47.72/50 was obtained.…”

Data Sheet 1_Milciclib-mediated CDK2 inhibition to boost radiotherapy sensitivity in colorectal cancer.pdf by Junjie Ma (730463)

“…</p>Methods<p>To evaluate the antitumor effects of Milciclib in CRC cells, we conducted assays measuring cell viability, cell cycle progression, and apoptosis in HCT116 and RKO cell lines following Milciclib treatment. …”

Effective Oral Favipiravir (T-705) Therapy Initiated after the Onset of Clinical Disease in a Model of Arenavirus Hemorrhagic Fever by Michelle Mendenhall (201521)

“…</p> <h3>Methodology/Principal Findings</h3><p>Here, we used a model of acute arenaviral infection in outbred guinea pigs based on challenge with an adapted strain of Pichindé virus (PICV) to further preclinical development of T-705 (Favipiravir), a promising broad-spectrum inhibitor of RNA virus infections. …”

Image_1_Genome-Wide Identification of a Regulatory Mutation in BMP15 Controlling Prolificacy in Sheep.TIFF by Louise Chantepie (8994092)

“…In order to identify this mutation, we have combined a case/control genome-wide association study with ovine 50k SNP chip genotyping, whole genome sequencing, and functional analyses. …”

Table_1_Genome-Wide Identification of a Regulatory Mutation in BMP15 Controlling Prolificacy in Sheep.DOCX by Louise Chantepie (8994092)

“…In order to identify this mutation, we have combined a case/control genome-wide association study with ovine 50k SNP chip genotyping, whole genome sequencing, and functional analyses. …”

VpsO-503 does not undergo tyrosine trans autophosphorylation <i>in vitro</i>. by Carmen Schwechheimer (9300303)

“…The lack of a second band at a slower migration indicates that we did not observe <i>in trans</i> phosphorylation on the C-terminal tail of the GST-fusion VpsO-503^K551A (catalytically inactive) mutant by the VpsO-503 WT enzyme. …”

Table_2_Genome-Wide Identification of a Regulatory Mutation in BMP15 Controlling Prolificacy in Sheep.DOCX by Louise Chantepie (8994092)

“…In order to identify this mutation, we have combined a case/control genome-wide association study with ovine 50k SNP chip genotyping, whole genome sequencing, and functional analyses. …”

Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107 by Yingwu Mei (102313)

“…SR vesicles enriched in RyR1 bound ∼48 [³H]S107 per RyR1 tetramer with EC₅₀ ∼52 µM and Hillslope ∼2. The effects of S107 and FKBP12 on RyR1 were examined under conditions that altered the redox state of RyR1. …”

Table_2_The burden of epilepsy in the People’s Republic of China from 1990 to 2019: epidemiological trends and comparison with the global burden of epilepsy.XLSX by Yun Shu (2016445)

“…However, Disability-Adjusted Life Years (DALY) decreased notably, and the proportion of Years of Life Lost (YLL) decreased from 62.73 to 39.03%. …”

Table_1_Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study.docx by Chengwei Fu (12129339)

“…We analyzed whole-brain amplitude of low-frequency fluctuations (ALFF) from preprocessed fMRI data across different intervention conditions. …”

OSM activates ERK-1/2, SAPK/JNK-1/2 MAP kinases, the PI3-kinase Akt and STAT1/3 in HCT116 cells and STAT3 activation is dependent of the LIFR. by Florian Beigel (174724)

“…One representative experiment (n = 3) is shown. TNF-α (50 ng/mL) served as positive control. (B) Activation and expression of phospho-STATs and protein loading of the respective STAT proteins were assessed by immunoblotting. …”

Data_Sheet_1_Influence of the First Wave of the COVID-19 Pandemic on Cancer Care in a German Comprehensive Cancer Center.docx by Johanna Kirchberg (11745386)

“…During the first shutdown, March–May 2020, the total number of presentations was 9.4% (−18.7, 1) less than during March–May 2019. This decrease was significant for curable cases of esophageal cancer [N = 37, 25.5% (−41.8, −4.4)] and colon cancer [N = 36, 17.5% (−32.6, 1.1)] as well as for all cases of biliary tract cancer [N = 26, 50% (−69.9, −15)] during the first shutdown from March 2020 to May 2020.…”

Intramyocardial Injection of Pig Pluripotent Stem Cells Improves Left Ventricular Function and Perfusion: A Study in a Porcine Model of Acute Myocardial Infarction by Xiaorong Li (66719)

“…The potential therapeutic benefits of iPS cell based treatment have been established in small-animal models of myocardial infarction (MI). We hypothesize that porcine iPS (piPS) cell transplantation may be an effective treatment for MI. …”

DataSheet1_v1_Selection Cuttings as a Tool to Control Water Table Level in Boreal Drained Peatland Forests.PDF by Kersti Leppä (9501851)

“…Using a process-based ecohydrological model, tested against data from the field trials, we show that the role of tree stand in controlling the WTL clearly decreases along the latitudinal climate gradient in Finland. …”

Data_Sheet_1_Proviral Quasispecies Diversity Is Not Associated With Virologic Breakthrough or CD4+ T Cell Loss in HIV-1 Elite Controllers.PDF by Suwellen S. D. de Azevedo (5369807)

“…<p>Elite controllers (EC) are able to control HIV-1 replication to extremely low levels (<50 HIV-1 RNA copies/mL) in the absence of antiretroviral therapy. …”