Synthesis of 1<i>H</i>‑Pyrazol-5-yl-pyridin-2-yl-[1,2,4]triazinyl Soft-Lewis Basic Complexants via Metal and Oxidant Free [3 + 2] Dipolar Cycloaddition of Terminal Ethynyl Pyridine... by Giri Babu Veerakanellore (7388243)

Subjects:

Image_6_Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells.TIF by Yung-Yu Yang (9343376)

“…Inhibition of HIF1A or NKX2-1 expression by siRNA transfection respectively decreased BMP4/NOTCH1/MKI67/OCT4/MUC5AC and NOTCH3/HEY1/CC10/FOXJ1 expression in the HBE cells cultured under intermittent H/R to the same levels under normoxia. …”

Image_8_Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells.TIF by Yung-Yu Yang (9343376)

“…Inhibition of HIF1A or NKX2-1 expression by siRNA transfection respectively decreased BMP4/NOTCH1/MKI67/OCT4/MUC5AC and NOTCH3/HEY1/CC10/FOXJ1 expression in the HBE cells cultured under intermittent H/R to the same levels under normoxia. …”

Image_7_Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells.TIF by Yung-Yu Yang (9343376)

“…Inhibition of HIF1A or NKX2-1 expression by siRNA transfection respectively decreased BMP4/NOTCH1/MKI67/OCT4/MUC5AC and NOTCH3/HEY1/CC10/FOXJ1 expression in the HBE cells cultured under intermittent H/R to the same levels under normoxia. …”

Characteristics of EF1-driven single copy NR1I2, NR4A1, or RORA stably-transfected cells. by Yoshinori Hasegawa (308240)

Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage - Fig 3 by Lucia Reh (546554)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Can inoculation with diazotrophic bacteria decrease the productivity loss of defoliated Vigna unguiculata (L.) Walp? by Caliane da S. Braulio (10469226)

A. We randomly selected 20 mutually exclusive groups of protein complexes that contained exactly five subunits; we mapped the corresponding gene pairs to SINaTRA scores, and plotte... by Alexandra Jacunski (5665486)

“…A SINaTRA cutoff of 0.95 has approximately half of its pairs associated with the same complex; however, a decrease in the cutoff shifts this balance. …”

Decreased Tks5 expression results in neural crest-derived defects. by Danielle A. Murphy (212554)

“…<p>(A–B) Melanophores within the trunk region above the yolk sac extension in control MO-injected and Tks5 MO-injected embryos were qualitatively (A) and quantitatively (B) analyzed. n = 15 embryos and SEM is shown by bar. p values obtained from Student's t-test. ** denotes p<0.01. …”

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. by Xiaowen Jiang (8291814)

Mutations affecting the Pho regulon can decrease stress-induced Lac⁺ reversion. by Janet L. Gibson (736950)

“…Strains (top to bottom in legend): SMR5235, SMR4953, SMR4059, SMR7351, SMR6762, SMR6760, SMR6759, SMR4061, SMR5860, SMR4047, and SMR4604. Fold decrease in the change in Lac⁺ from day 4 to day 5 relative to the <i>pho</i>⁺ strain SMR4562 was calculated for each genotype in several experiments of multiple cultures (like that shown in A). …”

FA decrease in 5STS impaired participants. by Charlotte Bernard (433013)

Chronic high glucose induces apoptosis and proteasome activities decrease in INS-1E cells. by Christophe Broca (538652)

Adiponectin-induced Irak3 plays an important role in rosiglitazone-mediated decrease of Mcp1. by Maarten Hulsmans (181118)

<i>Pw1</i> deletion does not result in significant decrease in oxytocin production and release. by Anne-Lyse Denizot (3170142)

Blocking C5L2 decreased C5a-primed neutrophils expression of membrane-bound PR3 (mPR3). by Jian Hao (160736)

SHIP-1 decreases NOD2-induced NF-κB activation in epithelial cells. by Claude Condé (150801)

Mean fecal egg count per individual before and after administration of a single oral dose albendazole. by Martin Walker (170282)