Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP) by Jamileh Hashemi (131207)

“…Using Nexus software analysis we combined the array-CGH data with data from gene expression profilings and identified genes that were altered in both inputs. A subset of genes identified as downregulated (<em>ALDH1A3</em>, <em>ANXA1</em>, <em>TLR4</em> and <em>RAB5A</em>) or upregulated (<em>COX6A1</em>, <em>NFIX</em>, <em>ME1</em>, <em>MAPK</em> and <em>TAP2</em>) were validated by siRNA in the tolerant or parental cells to alter sensitivity to PPP and confirmed to alter sensitivity to PPP in further cell lines.…”

Metabolomics raw data and table of extracted peak areas for BT478, BT530 and NHA cells cultured in the presence of MPA, Compound 3 (IC80) or vehicle control, for 6 hours. by Agata Monika Kieliszek (14650298)

“…The linear gradient employed was as follows: 0–2.5 min 99% A, 2.5–7.5 min decrease to 80% A, 7.5–13 min to 55% B 652 and finally 13–15 min to 99% B and held for 1 min. …”

Table_1_Regulation of miRNA expression in the prefrontal cortex by fecal microbiota transplantation in anxiety-like mice.docx by Simin Chen (9549665)

“…MiRNA analysis identified five key miRNAs affecting GAD pathogenesis, including mmu-miR-10a-5p, mmu-miR-1224-5p, mmu-miR-218-5p, mmu-miR-10b-5p, and mmu-miR-488-3p. …”

Image_1_P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells.JPEG by Alwin de Jong (4012250)

“…Expression of FoxP3 by systemic CD4⁺ T cells decreased 1.8 fold in ApoE3^*LeidenxPCAF^−/− after 5 months HFD and remained significantly reduced after 5 months of HFD. …”

The STIM2-TM domain activates the cytosolic region of STIMs less efficiently than that of STIM1. by Sisi Zheng (1574473)

“…Left: average time course of whole-cell I_CRAC currents measured at –100 mV. Currents mediated by STIM1121-ΔK developed significantly more slowly than control (time to peak, 72 ± 7 s versus 147 ± 9 s, <i>n</i> = 7, ****<i>P</i> < 0.0001, <i>t</i> test), with the maximal current density also reduced (–5.5 ± 0.8 pA/pF versus –1.5 ± 0.1 pA/pF, <i>n</i> = 7, *****<i>P</i> < 0.0004, <i>t</i> test). …”

Principle of time-resolved Scintillation Proximity Assay (SPA) to quantify stability of high-affinity radio-ligand binding to GPCRs. by Randi Westh Hansen (2585833)

“…When radioligands bind to immobilized receptors, energy from the radioisotope decay is efficiently transferred to the scintillator contained in the beads, thus generating a detectable light signal. If the buffer, including detergent, causes the loss of receptor affinity to radiolabeled ligand, the signal will start to decrease irreversibly. …”

Building Strain with Large Macrocycles and Using It To Tune the Thermal Half-Lives of Hydrazone Photochromes by Quan Li (157017)

“…Strain has been used as a tool to modulate the reactivity (e.g., mechanochemistry) and thermal isomerization kinetics of photochromic compounds. …”

Building Strain with Large Macrocycles and Using It To Tune the Thermal Half-Lives of Hydrazone Photochromes by Quan Li (157017)

“…Strain has been used as a tool to modulate the reactivity (e.g., mechanochemistry) and thermal isomerization kinetics of photochromic compounds. …”

Probing Interaction between ssDNA and Carbon Nanotubes by Raman Scattering and Electron Microscopy by Masayuki Shoda (2380057)

“…We report experimental results of Raman scattering showing that single-stranded DNA (ssDNA) effectively modifies the electronic structure of metallic carbon nanotubes with the diameter of 1.5−1.6 nm but not for the same diameter class of semiconducting tubes. …”

Endothelial density analysis by age group of corneal donors in an eye bank in Paraná State, Brazil by Karla Mulinari Vicini (10371090)

“…In the evaluation from the second to the sixth decade, there was no pattern, sometimes there was an increase, sometimes a decrease in the average endothelial density.</p><p></p>…”

Reduced but functional CD8+ T-cell compartment after fully-mismatched HLA class I thymus transplantation. by Adriana S. Albuquerque (323475)

“…<p>(A) Circulating CD8+ αβ T-cells analysed 58 months post-transplantation (5% of total lymphocytes; 83cells/µl) by flow cytometry in terms of: naïve/memory/effector phenotype assessed by CD45RA and CD27 expression; levels of activation markers (CD38 and HLA-DR); IFN-γ and IL-2 production upon PMA+ionomycin stimulation; <i>ex vivo</i> frequency of cycling cells (Ki-67+); and <i>ex vivo</i> frequency of apoptotic cells assessed by annexin V staining. …”

Nephrin deletion in adult mature glomerulus results in focal segmental glomerulosclerosis and proteinuria. by Rakesh Verma (151646)

“…<p>(A) Mice with tamoxifen-induced nephrin deletion develop proteinuria at 6–8 weeks following tamoxifen. …”

Building Strain with Large Macrocycles and Using It To Tune the Thermal Half-Lives of Hydrazone Photochromes by Quan Li (157017)

“…Strain has been used as a tool to modulate the reactivity (e.g., mechanochemistry) and thermal isomerization kinetics of photochromic compounds. …”

Schematic representation of dsRNA- and virus-induced beta cell apoptosis. by Maikel L. Colli (179059)

LCN2 reduced the increase of endothelial permeability in response to TNFα. by Yang Du (506908)

“…(C) TNFα treatment significantly decreased the total protein expression of VE-cadherin, claudin-5, occludin, and ZO-1. *, p<0.05 compared to the control (one-way ANOVA). n = 3 independent experiments. …”

Oligomerization of hIKK2 dimers. by Smarajit Polley (420092)

“…(E) In vitro kinase assay reveals that catalytic activity of hIKK2 with mutations that disrupt the V-shaped interface (lanes 3–5) is drastically reduced compared to wild-type protein (WT-lane 2). …”

Building Strain with Large Macrocycles and Using It To Tune the Thermal Half-Lives of Hydrazone Photochromes by Quan Li (157017)

“…Strain has been used as a tool to modulate the reactivity (e.g., mechanochemistry) and thermal isomerization kinetics of photochromic compounds. …”

Supplementary Material for: Sensitivity of Blood Volume Monitoring for Fluid Status Assessment in Hemodialysis Patients by Maduell F. (4137250)

Comparison of methods to monitor for myelopathic progression in DCM. by Allan R. Martin (3772705)

“…<p>Top panel: The bar graph displays the fraction of subjects that are deemed to be stable (green), borderline declined (yellow), or declined (red) for each clinical and MRI method of monitoring. For mJOA, a 1-point decrease is considered borderline and ≥ 2-point decreases are considered declined. …”

Specificity and sensitivity of C4BP and FH binding by <i>P. intermedia</i> ATCC 25611. by Sven Malm (326396)

“…<p>A) Binding of 250 kcpm ¹²⁵I-C4BP was competed by using 30 µg (final concentration 1.32 µM) unlabeled C4BP, C) ¹²⁵I-FH binding by <i>P. intermedia</i> ATCC 25611 was competed by 7.5 µg (final concentration 1.25 µM) unlabeled FH. …”