Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents by WooChan Kim (10690503)

“…Core assembly modulators of viral capsid proteins have been developed as an effective treatment of chronic hepatitis B virus (HBV) infection. In this study, we synthesized novel potent pyrimidine derivatives as core assembly modulators, and their antiviral effects were evaluated in in vitro and in vivo biological experiments. …”

Design and Synthesis of Novel sEH Inhibitors for the Treatment of Inflammatory Bowel Disease by Huashen Xu (13987046)

“…Especially, lead compounds <b>A1</b> and <b>A9</b> showed potent inhibitory activities against sEH (<b>A1</b> and <b>A9</b>; hsEH IC₅₀ = 0.1 nM, msEH IC₅₀ = 0.1 nM). …”

Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse by Charles E. Hay (5470526)

“…In separate experiments 21 days and 50 days after injecting mice with AAV-scFvs mice were challenged with METH <i>in vivo</i>. …”

YY1 associates with the arginine methyl transferase PRMT5 to regulate ITCH repression during Mtb infection. by Salik Miskat Borbora (9381455)

Meta-analyses of the association of <i>G6PC2</i> allele variants with elevated fasting glucose and type 2 diabetes by Yuanyuan Shi (563992)

“…Per increment of G allele at rs560887 and A allele at rs573225 resulted in a FG 0.070 mmol/l and 0.075 mmol/l higher (ß (95% CI) = 0.070 (0.060, 0.079), <i>p</i> = 4.635e-50 and 0.075 (0.065, 0.085), <i>p</i> = 5.856e-48, respectively). …”

Determinants for Substrate Recognition in the Glycyl Radical Enzyme Benzylsuccinate Synthase Revealed by Targeted Mutagenesis by Iryna Salii (10219821)

GQ-16 treatment reduces hepatic triglyceride accumulation. by Michella S. Coelho (2637202)

Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening by Shoya Yamada (1639105)

Repression of the cGAS-STING DNA sensing pathway in ATRX knockdown HFFs. by Anne-Charlotte Stilp (3520415)

Impaired ISG expression in ATRX knockdown HFFs. by Anne-Charlotte Stilp (3520415)

Fig 4 - by Te-Hsing Hsu (16973374)

S1 File - by Ingmar Lundquist (46422)

“…<div><p>The impact of islet neuronal nitric oxide synthase (nNOS) on glucose-stimulated insulin secretion (GSIS) is less understood. We investigated this issue by performing simultaneous measurements of the activity of nNOS <i>versus</i> inducible NOS (iNOS) in GSIS using isolated murine islets. …”

The effects of purified cardiac leiomodin2 on actin assembly dynamics. by Dávid Szatmári (4510156)

Mitochondrial reactive oxygen species (mitoROS) assay using H9c2 overexpressing human TFAM (hTFAM) or rat Twinkle-Flag (rTwinkle) and mitochondria from TFAM mice and Twinkle (TW) m... by Masataka Ikeda (428186)

ATRX interacts with IRF3 and modulates IRF3 activity. by Anne-Charlotte Stilp (3520415)

Hypomyelination and demyelination in the spinal cord of <i>taiep</i> rats. by Jose R. Eguibar (8563227)

“…The data is the mean ± S.E.M. of six subjects of WT and <i>taiep</i> rats.…”

Bexarotene pretreatment significantly suppressed HBV and HDV infections in primary human hepatocytes (PHH). by Sameh A. Gad (12269979)

Reduced IRF3 and TBK1 phosphorylation in ATRX knockdown HFFs. by Anne-Charlotte Stilp (3520415)

Cardiac leiomodin2 binds to the sides of actin filaments. by Dávid Szatmári (4510156)

Representative Boolean gating strategy for the analysis of the cytokine co-expression profiles of CD4+ T cells after stimulation with T. cruzi antigens. by María Ailén Natale (6843422)