Gossypol prevents TGF-β1 induced fibronectin expression. by Jennifer L. Judge (5278415)

Gossypol treats bleomycin-induced fibronectin expression. by Jennifer L. Judge (5278415)

A homozygous missense variant in <i>VWA2</i>, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux by Amelie T. van der Ven (4782093)

“…By applying <i>in vitro</i> assays, we demonstrate that the Arg446Cys mutation decreases translocation of monomeric VWA2 protein and increases translocation of aggregated VWA2 protein into the extracellular space. …”

Y-P30 does not alter somatodendritic differentiation of cortical neurons but promotes filopodia pruning and morphological maturation of spines on pyramidal neurons. by Janine R. Neumann (6330863)

“…(D) Y-P30 did not alter the density of interneuronal (IN) dendritic protrusions and basal dendritic protrusions of pyramidal cells (PC) at DIV 10 (treated with 1 μM Y-P30 at DIV 7 and DIV 9) and DIV 20 (daily one pulse of 1 μM Y-P30 from DIV 15–19). Plotted is the mean number ± SEM per 100 μm dendritic length. (E) Y-P30 decreased the density of protrusions on secondary oblique branches from the apical dendrites of pyramidal cells at DIV 10 by 27% and at DIV 20 by 13%. …”

Effects of Y-P30 on expression and phosphorylation of glutamate receptors, Src, and ERK. by Janine R. Neumann (6330863)

“…(A) Representative blot at DIV 20; per lane, 50% of a lysate from a vehicle-treated control and a 60 min Y-P30-treated OTC was loaded on the left and the right side of a gel. …”

Participant characteristics. by Ronald Kusolo (13200268)

“…The risk factor prevalences that decreased significantly were: inadequate physical activity from 5.0% in 2014 to 3.6% in 2023 (p=0.003), and current smoke tobacco use from 9.6% in 2014, to 8.3% in 2023 (p= 0.046). …”

Assessing resolution and calibration of confidence. by Medha Shekhar (19502698)

“…Confidence is then computed as and therefore, when <i>T</i>>1, the network’s confidence gets scaled down. We found that temperature scaling indeed reduced overconfidence in all networks (4-layer CNN: confidence decreased from 0.968 to 0.737; VGG-10: confidence decreased from 0.964 to 0.783, ResNet-50: confidence decreased from 0.982 to 0.748). …”

image_1_Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pER... by Giuseppe Castellano (5258120)

“…Treatment by C1-inhibitor (C1-INH) significantly preserved the phenotype of pericytes maintaining microvascular density and capillary lumen area at tubulointerstitial level. In vitro, C5a transdifferentiated human pericytes in myofibroblasts, with increased αSMA expression in stress fibers, collagen I production, and decreased antifibrotic protein Id2. …”

image_2_Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pER... by Giuseppe Castellano (5258120)

“…Treatment by C1-inhibitor (C1-INH) significantly preserved the phenotype of pericytes maintaining microvascular density and capillary lumen area at tubulointerstitial level. In vitro, C5a transdifferentiated human pericytes in myofibroblasts, with increased αSMA expression in stress fibers, collagen I production, and decreased antifibrotic protein Id2. …”

image_3_Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pER... by Giuseppe Castellano (5258120)

“…Treatment by C1-inhibitor (C1-INH) significantly preserved the phenotype of pericytes maintaining microvascular density and capillary lumen area at tubulointerstitial level. In vitro, C5a transdifferentiated human pericytes in myofibroblasts, with increased αSMA expression in stress fibers, collagen I production, and decreased antifibrotic protein Id2. …”

image_4_Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pER... by Giuseppe Castellano (5258120)

“…Treatment by C1-inhibitor (C1-INH) significantly preserved the phenotype of pericytes maintaining microvascular density and capillary lumen area at tubulointerstitial level. In vitro, C5a transdifferentiated human pericytes in myofibroblasts, with increased αSMA expression in stress fibers, collagen I production, and decreased antifibrotic protein Id2. …”

Uganda 2023 NCD risk factor STEPS survey data. by Ronald Kusolo (13200268)

“…The risk factor prevalences that decreased significantly were: inadequate physical activity from 5.0% in 2014 to 3.6% in 2023 (p=0.003), and current smoke tobacco use from 9.6% in 2014, to 8.3% in 2023 (p= 0.046). …”

Uganda 2014 NCD risk factor STEPS survey data. by Ronald Kusolo (13200268)

“…The risk factor prevalences that decreased significantly were: inadequate physical activity from 5.0% in 2014 to 3.6% in 2023 (p=0.003), and current smoke tobacco use from 9.6% in 2014, to 8.3% in 2023 (p= 0.046). …”

Active Surface Area-Dependent Water Harvesting of Desert Beetle-Inspired Hybrid Wetting Surfaces by Jothi Prakash Chakrapani Gunarasan (18065758)

“…A high water collection capacity of 2050 mg cm^–2 h^–1 was achieved, and the hydrophilic active area-engineered surface retained its efficiency even after 50 test cycles. We further demonstrate high collection efficiency with a square pattern compared to a triangular path-like-patterned surface. …”

<i>Gpdh1; Ldh</i> double mutants display increased <i>upd3</i> expression. by Madhulika Rai (4352803)

Changes in the separation and spread of evidence distributions induced by energy, contrast, and variability manipulations. by Medha Shekhar (19502698)

Assessing binding site representation across dense arrays. by Virgile Andreani (17087764)

“…<p>(A) For the |<i>R</i>| = 10 randomly generated binding sites of Collection 1 we found 1854 optimal sequences (each fitting 6 binding sites within <i>L</i> = 50 bp). …”

Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor by Olga Gorelenkova Miller (2900069)

“…Treatment of the BV2 microglial cell line with CWR-J02 led to inhibition of intracellular Grx1 activity with an IC₅₀ value (37 μM). CWR-J02 treatment decreased lipopolysaccharide-induced inflammatory gene transcription in the microglial cells in a parallel concentration-dependent manner, documenting the anti-inflammatory potential of CWR-J02. …”

Dissociations between meta-d’ and d’. by Medha Shekhar (19502698)

“…<p>We tested the three networks (4-layer CNN, VGG-19 and ResNet-50) on the task paradigm from Maniscalco et al. (2016) [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1012578#pcbi.1012578.ref018" target="_blank">18</a>] which demonstrated a dissociation between d’ and meta-d’ when the contrast of one stimulus category (S₁) remains fixed while the contrast of the other stimulus is increased in discrete steps (S₂) For this design, meta-d’ increases with d’ as expected for trials in which the observer responds "S₂", but meta-d’ decreases with d’ for trials where the observer responds "S₁". …”

Moderating role of state fear of failure on the link between perceived autonomy support and affective rumination. by Elif Manuoglu (17199865)