Short and Long-Term Effects of the Angiotensin II Receptor Blocker Irbesartan on Intradialytic Central Hemodynamics: A Randomized Double-Blind Placebo-Controlled One-Year Intervent... by Christian Daugaard Peters (748219)

“…Mean start and mean end cardiac output, stroke volume, total peripheral resistance, heart rate, and mean arterial pressure were stable and similar in the two groups, whereas central blood volume increased slightly but similarly over time. …”

Supplementary Material for: First-in-human effects of PPT1 inhibition using the oral treatment with GNS561/ Ezurpimtrostat in patients with primary and secondary liver cancers by Harding J.J. (12088145)

“…Liver trough concentrations were much higher than in plasma a median time of 28 days of administration with a mean liver to plasma ratio of 9559 (Min 149-Max 25759), which is in accordance with rat preclinical data observed after repeated administration. …”

Video_1_Sensorimotor content of multi-unit activity recorded in the paramedian lobule of the cerebellum using carbon fiber microelectrode arrays.MP4 by Esma Cetinkaya (18073042)

“…Linear regression was performed to predict the EMG signal envelopes using the PML activity for various time shifts (±25, ±50, ±100, and ± 400 ms) between the two signals to determine a causal relation. …”

Rhesus macaque CD4 alleles are universally defective for HIV-1 entry. by Cody J. Warren (563898)

“…Genotype information was used to phase SNPs using Phase 2.1 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000304#pbio.3000304.ref081" target="_blank">81</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000304#pbio.3000304.ref082" target="_blank">82</a>] in DNAsp v5 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000304#pbio.3000304.ref083" target="_blank">83</a>]. …”

Table_1_Large German Multicenter Experience on the Treatment Outcome of 207 Patients With Adenoid Cystic Carcinoma of the Major Salivary Glands.docx by Sati Akbaba (7213499)

“…In multivariate analysis, we could identify two prognostic subgroups: one subgroup resulting in decreased LC, PFS and OS rates and another subgroup having an additional survival disadvantage in PFS and OS. …”

Supplementary Material for: Human Oral Mucosal Stem Cells Reduce Anastomotic Leak in an Animal Model of Colonic Surgery by Kent I. (10699344)

“…The objective of this study was to evaluate whether hOMSC can decrease anastomotic leak rates in a murine model of colon surgery. …”

Image_1_Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following... by Shardulendra Prasad Sherchand (13108779)

“…Therefore, we first optimized an in vitro assay that quantifies recombinant Gmd lysis of the M. luteus cell wall and used it to demonstrate the 50% neutralizing concentration (NC₅₀) of a humanized anti-Gmd mAb (TPH-101) to be ~15.6 μg/ml. …”

Image_3_Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following... by Shardulendra Prasad Sherchand (13108779)

“…Therefore, we first optimized an in vitro assay that quantifies recombinant Gmd lysis of the M. luteus cell wall and used it to demonstrate the 50% neutralizing concentration (NC₅₀) of a humanized anti-Gmd mAb (TPH-101) to be ~15.6 μg/ml. …”

Image_2_Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following... by Shardulendra Prasad Sherchand (13108779)

“…Therefore, we first optimized an in vitro assay that quantifies recombinant Gmd lysis of the M. luteus cell wall and used it to demonstrate the 50% neutralizing concentration (NC₅₀) of a humanized anti-Gmd mAb (TPH-101) to be ~15.6 μg/ml. …”

lncRNA ZFPM2-AS1 promotes retinoblastoma progression by targeting microRNA miR-511-3p/paired box protein 6 (PAX6) axis by Wenchang Ni (7907711)

“…We also found that ZFPM2-AS1 targets miR-511-3p to upregulate PAX6 in Y79 and SO-RB50 cells. …”

ATF4 knockdown in the ADRP retinas reduces overall ER stress response (N = 4). by Yogesh Bhootada (408443)

“…The T17M ATF4^+/- retinas were the only group with a significant decrease in peIF2a (P<0.01 as compared to T17M retinas) and increased GADD34 protein levels (<i>P</i><0.05 for all groups). …”

UTX-1 is required for VPA action in <i>C. elegans</i> embryos and in human cells. by Rakel Brendsdal Forthun (121022)

“…<p><b>A</b>) Two <i>UTX</i> wild type cell lines (MV4-11 and NB4) as well as the <i>UTX</i> mutant cell line THP-1 were treated with 1 mM VPA for 48 hours and analyzed for H3K27me3 and H2BK120ac expression. The mean intensity on one representative Western blot was calculated and normalized to beta-actin. …”

Influence of mentalis muscle relaxation on oronasal breathing by Mara Letícia Gobbis (10445129)

“…The mentalis muscle, in its turn, had in the pre- and post-phase, respectively, a mean (standard deviation) of 199.31 (279.77) µV and 114.58 (253.56) µV. …”

Impacts of Human Disturbance on Large Prey Species: Do Behavioral Reactions Translate to Fitness Consequences? by Mathieu Leblond (457233)

“…We hypothesized that human activities and infrastructure cause a decrease in the individual performance of preys because of anthropogenically enhanced predation risk. …”

M-cells are depleted with αRANKL antibody treatment. by Aimee L. Cunningham (650204)

“…<p>BALB/c mice (n = 3 per group) were treated i.p. with 250 μg of either rat Ig (a-b) or αRANKL antibody IK22-5 (c-d) on days 0, 2, 4, and 6. …”

Brazilian Women’s Health after 65 Years of Age by Angela Maggio da Fonseca (4717704)

“…Results The age of the patients on their first clinic visit ranged from65 to 98 years, with a mean age of 68.56 ± 4.47 years; their mean age at the time of natural menopause was 48.76 ± 5.07 years. …”

Igf signaling is required for contribution of<i>gata4:EGFP</i> positive cardiomyocytes to the regenerating area. by Ying Huang (53474)

“…<p><i>gata4:EGFP</i> fish were treated with the Igf1r inhibitor NVP-AEW541 from 2–14 dpa (n = 12) (B, D) and 7–10 dpa (n = 5) (F, H). DMSO was used as a control (14dpa: n = 10; 10 dpa: n = 6) (A, C, E, G). …”

N-acetylcysteine Protects against Apoptosis through Modulation of Group I Metabotropic Glutamate Receptor Activity by Lili Sun (162122)

“…In this study, we investigated the effects of N-acetylcysteine (NAC), a precursor of the antioxidant glutathione, on group I mGlus activation in apoptosis of glial C6 and MN9D cell lines, and a rat model of Parkinson's disease (PD). …”

Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons by Matthew Dodson (4388749)

“…Finally, inhibition of autophagy initiation using 3-methyladenine (3MA) also results in a significant decrease in mitochondrial function and network length. …”

Evaluation of Pelleting Mealworm (Tenebrio Molitor) Powder with Chokeberry By-product Meal To improve Duck Production and Meat Quality Traits by IH Choi (5838176)

“…<div><p>ABSTRACT This study aimed to evaluate the effects of dietary supplementation pelleted Tenebrio molitor (TM) powder with chokeberry by-product (CBP) meal on duck production and meat quality traits. A total of 180 0-day-old Pekin ducks were allocated randomly between three dietary groups viz., control, Treatment 1, and Treatment 2, with three pens per group and twenty birds per pen, characterized by increasing levels of pelleted TM powder with CBP meal in concentration of 0%, 1.5%, and 3%, respectively, and reared until 42 days of age in a completely randomized design. …”