The Physiological Effects of Deleting the Mouse <em>Slc30a8</em> Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background by Lynley D. Pound (150058)

“…</p> <h3>Results</h3><p>Male C57BL/6J <em>Slc30a8</em> knockout (KO) mice had normal fasting insulin levels and no change in glucose-stimulated insulin secretion (GSIS) from isolated islets in marked contrast to the ∼50% and ∼35% decrease, respectively, in both parameters observed in male mixed genetic background <em>Slc30a8</em> KO mice. …”

Data_Sheet_1_Effects of Different Grazing Disturbances on the Plant Diversity and Ecological Functions of Alpine Grassland Ecosystem on the Qinghai-Tibetan Plateau.docx by Wenlong Li (571749)

“…Aboveground biomass (AGB) and belowground biomass (BGB) decreased, respectively, by 41.91% (95% CI: −50.91 to −32.88%) and 17.68% (95% CI: −26.94 to −8.52%). …”

Outcomes from a cohort of patients with acute kidney injury subjected to continuous venovenous hemodiafiltration: The role of negative fluid balance by Thais Oliveira Claizoni dos Santos (3937481)

“…Knowing this fact, it may be possible to change the course of the disease and decrease the high mortality rate observed. Thus, we aimed to evaluate the main risk factors for death in AKI patients needing CRRT.…”

Supplementary Material for: ESCAPE: An Open-Label Trial of Personalized Immunotherapy in Critically lll COVID-19 Patients by Karakike E. (11776763)

“…The primary outcome was ≥25% decrease in the Sequential Organ Failure Assessment (SOFA) score and/or 50% increase in the respiratory ratio by day 8; 28-day mortality, change of SOFA score by day 28, serum biomarkers, and cytokine production by mononuclear cells were secondary endpoints. …”

DataSheet1_An agent-based model of cardiac allograft vasculopathy: toward a better understanding of chronic rejection dynamics.PDF by Elisa Serafini (16972167)

“…<p>Cardiac allograft vasculopathy (CAV) is a coronary artery disease affecting 50% of heart transplant (HTx) recipients, and it is the major cause of graft loss. …”

Data_Sheet_1_Cost-effectiveness analysis of vaccination against COVID-19 in China.PDF by Huixuan Zhou (2146729)

“…</p>Results<p>Our simulation indicates that compared with a no-vaccination scenario, vaccination amongst the general population in mainland China would reduce the infection rate from 100% to 45.3% and decrease the death rate from 6.8% to 3.1%. Consequently, the strategy will lead to a saving of 37,664.77 CNY (US$5,256.70) and a gain of 0.50 QALYs per person per year on average (lifetime QALY and productivity loss due to immature death are included). …”

Table_1_Relationship between BMI and prognosis of chronic heart failure outpatients in Vietnam: a single-center study.docx by Hoai Thi Thu Nguyen (14256851)

“…</p>Methods<p>Between 2018 and 2020, we prospectively enrolled consecutive outpatients with clinically stable CHF in an observational cohort, single-center study. …”

Table_1_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS4895”... by Sayantan Sarkar (11975699)

“…The phenotyping results showed that 88% of slow, 50% of moderate, and 11% of high wilting genotypes expressed the TR_lim trait at 32°C and 43, 10, and 0% at 37°C, respectively. …”

Image_1_Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infa... by Yang Xiao (146335)

“…</p><p>Results: Pilot studies suggested potential cardioprotective effects for 50 mg/kg NR (p = 0.005) and 500 μg/kg melatonin (p = 0.12), but not for Empa or Fingo. …”

Effects of siRNA on RET/PTC3 Junction Oncogene in Papillary Thyroid Carcinoma: From Molecular and Cellular Studies to Preclinical Investigations by Hafiz Muhammad Ali (554920)

“…Among four siRNAs and five concentrations tested against <i>RET/PTC3</i>, an efficient siRNA <i>RET/PTC3</i> and an appropriate dose (50 nM) were selected which showed significant inhibition (<i>p</i><0.001) of gene (RT-qPCR) and protein (Western blot) expressions. …”

Neutrophil extracellular traps contribute to the pathogenesis of leprosy type 2 reactions by Camila Oliveira da Silva (7365539)

“…<div><p>Up to 50% of patients with the multibacillary form of leprosy are expected to develop acute systemic inflammatory episodes known as type 2 reactions (T2R), thus aggravating their clinical status. …”

Image_2_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS4895”... by Sayantan Sarkar (11975699)

“…The phenotyping results showed that 88% of slow, 50% of moderate, and 11% of high wilting genotypes expressed the TR_lim trait at 32°C and 43, 10, and 0% at 37°C, respectively. …”

Data_Sheet_1_Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces... by Yang Xiao (146335)

“…</p><p>Results: Pilot studies suggested potential cardioprotective effects for 50 mg/kg NR (p = 0.005) and 500 μg/kg melatonin (p = 0.12), but not for Empa or Fingo. …”

Table_1_Safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of WBP216, a novel IL-6 monoclonal antibody, in patients with rheumatoid arthritis: A phase Ia random... by Xiaomei Leng (614420)

“…Background<p>WBP216 is a novel human immunoglobulin G1 (IgG1) monoclonal antibody for interleukin (IL)-6. We aimed to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of a single ascending dose (SAD) of WBP216 in patients with rheumatoid arthritis (RA).…”

Image_1_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS4895”... by Sayantan Sarkar (11975699)

“…The phenotyping results showed that 88% of slow, 50% of moderate, and 11% of high wilting genotypes expressed the TR_lim trait at 32°C and 43, 10, and 0% at 37°C, respectively. …”

DataSheet_5_T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis.pdf by Ni An (511459)

“…</p>Results<p>T2DM is associated with a reduced risk of esophageal (OR: 0.77, 95% CI: 0.71 to 0.83, P< 0.001), gastric (OR: 0.87, 95% CI: 0.84 to 0.90, P< 0.001) and colorectal cancer (OR: 0.88, 95% CI: 0.85 to 0.91, P< 0.001) and hepatocellular carcinoma (OR: 0.92, 95% CI: 0.86 to 0.97, P = 0.005) and an increased risk of pancreatic cancer (OR: 1.92, 95% CI: 1.47 to 2.50, P< 0.001) in East Asian population. T2DM causes decreased fasting insulin levels (OR = 0.966, 95% CI: 0.95 to 0.98, P< 0.001) and increased glycated hemoglobin levels (OR=1.41, 95% CI: 1.39 to 1.44, P<0.001). …”

Data_Sheet_2_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS... by Sayantan Sarkar (11975699)

“…The phenotyping results showed that 88% of slow, 50% of moderate, and 11% of high wilting genotypes expressed the TR_lim trait at 32°C and 43, 10, and 0% at 37°C, respectively. …”

Parallel fibers from areas outlined in (a) were analyzed in 250-μm-thick vibratome slices taken from HH35 cerebella after downregulation of AX-1 by RNAi at HH34 (a-c,f) by Thomas Baeriswyl (90047)

“…As an independent method for AX-1 perturbation, we used antibodies to block AX-1 function at the protein level. …”

Table_1_Compensatory brain activity pattern is not present in older adults during the n-back task performance—Findings based on EEG frequency analysis.DOC by Ludmiła Zając-Lamparska (8056364)

“…To strengthen the cognitive interpretation of compensatory brain activity in older adults, we searched for its indicators in brain activity measured by EEG.…”

Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects by Jisuk Park (7405823)

“…<div><p>Background</p><p>Quantification of abdominal muscle mass by cross-sectional imaging has been increasingly used to diagnose sarcopenia; however, the technical method for quantification has not been standardized yet. We aimed to determine an optimal method to measure the abdominal muscle area.…”