CRISPRi knockdown of Lon protease to increase half-life. by Nicholas A. Rossi (3622865)

“…Bivariate scatter plots show P_<i>inaA</i> and P_<i>acrAB</i> expression levels at the final time point across n = 5 microcolonies. The two distributions are statistically different by the 2D Kolmogorov-Smirnov test, p<0.001. …”

Tuning of Msn2 expression in rapidly growing cells. by Michal Chapal (7961111)

“…(F–G) Noisy Msn2 expression decreases stress protection and growth rate: we generated six strains with Msn2-YFP expressed under different promoters, which control genes with noisier expression than Msn2 but have a similar mean abundance (mean abundance in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000289#pbio.3000289.s005" target="_blank">S5 Fig</a>), and deletion of <i>MSN4</i>. …”

Prevalence of Vision Loss in North Africa and Middle East in 2020: Magnitude and Temporal Trends by Vision Loss Expert Group of the Global Burden of Disease Study (20987841)

“…Between 2000 and 2020, age-standardised prevalence of blindness and other categories of visual impairment decreased in all ages and among adults over than 50 years.…”

Table_1_Benthic and Fish Interactions With Pipeline Protective Structures in the North Sea.DOCX by Michael Redford (10671954)

“…Six groups were higher in abundance within the 500 m fisheries exclusion zone around platforms, compared to outside of the zone, with other gadoids showing the highest difference at 1.83 times (1.09, 2.89, 95% CrI) times higher inside zones. Five groups decreased in abundance with an increase in fishing effort, with the biggest effect observed on grazers which decreased in abundance by 28% (14 – 40, 95% CrI) per 50 h of fishing. …”

Table_2_Benthic and Fish Interactions With Pipeline Protective Structures in the North Sea.xlsx by Michael Redford (10671954)

“…Six groups were higher in abundance within the 500 m fisheries exclusion zone around platforms, compared to outside of the zone, with other gadoids showing the highest difference at 1.83 times (1.09, 2.89, 95% CrI) times higher inside zones. Five groups decreased in abundance with an increase in fishing effort, with the biggest effect observed on grazers which decreased in abundance by 28% (14 – 40, 95% CrI) per 50 h of fishing. …”

Effect of TRPV4-mediated activation of SK3 channels on membrane potential, Vm. by Jonathan Berrout (555482)

“…</b> Effect of TRPV4 activation with GSK101 (50 nM) leading to membrane hyperpolarization of Vm (decreased RFU), as expected for SK3 and BK activation. …”

Data Sheet 1_The association of healthy eating index score and n-3 fatty acid intake with cardiovascular diseases incidence and lipid biomarkers in Alberta’s tomorrow project cohor... by Reihane Taheri (14188808)

“…</p>Methods<p>This is a prospective study on a subset of ATP study participants (n = 23,248), with the mean age of 50.2 (35-69) years, 36% male and 64% female, and no history of cancer or CVD in Alberta, Canada. …”

Ama controls the pool of myoblast number independently of Nrt. by Blandine Moucaud (11844047)

“…<b>(L)</b> Dot-plot graph showing the mean number of Twi-positive myoblasts per disc in rescue experiments using R32D05-Gal4 driver. …”

Concentration-time curves of the study group patients at post-operative 1 week, 3 weeks, 8 weeks and 12 months. by Ryuto Nakazawa (8115236)

DataSheet_1_Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3.docx by Andrei M. Gigolaev (9090713)

“…As predicted by the modeling, this derivative shows decreased activity on K_V1.1 (IC₅₀ ~550 nM) and 1.2 (~200 nM). …”

Transcriptional Profiling of Human Familial Longevity Indicates a Role for <em>ASF1A</em> and <em>IL7R</em> by Willemijn M. Passtoors (188329)

“…We first compared gene expression profiles from whole blood samples between 50 nonagenarians and 50 middle-aged controls, resulting in identification of 2,953 probes that associated with age. …”

Protective effect of L-carnitine on myocardial injury in rats with heatstroke by Xisong Wang (10394395)

“…Methods: orty-eight rats were randomly divided into control, heatstroke and 25, 50 and 100 mg/kg L-carnitine groups. The last three groups were treated with 25, 50 and 100 mg/kg L-carnitine, respectively, for seven successive days. …”

Ran knock down by RNAi results in abnormal neurite morphology in mouse neurons. by Katharine J. Sepp (50335)

“…Equal loadings of total protein shown by tubulin signal demonstrates a decrease in the amount of Ran by about 50% in the presence of <i>Ran</i> Rnai-2 and when the two constructs are combined. …”

Source apportionment of PM_2.5 at IMPROVE monitoring sites within and outside of marine vessel fuel sulfur emissions control areas by Robert A. Kotchenruther (11235072)

“…These sites saw a statistically significant 14.0% increase, a 21.0% decrease, or no statistically significant change, respectively, when comparing time periods pre and post ECA enforcement.…”

S1 Fig - by Magdalena Miranda (14667161)

“…AC: 47.89 ± 3.38, PC: 47.39 ± 3.07, NC: 49.74 ± 3.50. <b>(B)</b> Total object exploration percentage for AC, PC, and NC in the different expositions to the same condition during the 1-day version of the task. …”

Data_Sheet_1_Gaussian Graphical Models Reveal Inter-Modal and Inter-Regional Conditional Dependencies of Brain Alterations in Alzheimer's Disease.pdf by Martin Dyrba (417214)

“…We obtained data from N = 972 subjects from the Alzheimer's Disease Neuroimaging Initiative. …”

Sample gallery of the spatial nuclear patterns produced in Filter 1. by Angelika Manhart (1379565)

“…Combinations of forces (att: attractive, rep: repulsive, dec: decreasing, inc: increasing, con: constant). We show results of varying the character of internuclear and nuclear-cell side forces. …”

Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection by Zijin Chen (7338062)

“…</p> <p>In total, 823 patients were enrolled (50.5% male) with a mean age of 60.9 ± 14.9 years. …”

Table_1_Beneficial Cardiac Structural and Functional Adaptations After Lumbosacral Spinal Cord Epidural Stimulation and Task-Specific Interventions: A Pilot Study.xlsx by Bonnie E. Legg Ditterline (9521390)

“…We found significant improvements to the cardiac structure (left ventricular mass = 10 ± 2 g, p < 0.001; internal dimension during diastole = 0.1 ± 0.04 cm, p < 0.05; internal dimension during systole = 0.06 ± 0.03 cm, p < 0.05; interventricular septum dimension = 0.04 ± 0.02 cm, p < 0.05), systolic function (ejection fraction = 1 ± 0.4%, p < 0.05; velocity time integral = 2 ± 0.4 cm, p < 0.001; stroke volume = 4.4 ± 1.5 ml, p < 0.01), and diastolic function (mitral valve deceleration time = -32 ± 11 ms, p < 0.05; mitral valve deceleration slope = 50 ± 25 cm s^–1, p < 0.05; isovolumic relaxation time = −6 ± 1.9 ms, p < 0.05) with each subsequent scES intervention. …”

Effects of tramadol and acepromazine on intraocular pressure and pupil diameter in young healthy cats by Deise Cristine Schroder (4958143)