Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Decreased Tks5 expression results in neural crest-derived defects. by Danielle A. Murphy (212554)

“…<p>(A–B) Melanophores within the trunk region above the yolk sac extension in control MO-injected and Tks5 MO-injected embryos were qualitatively (A) and quantitatively (B) analyzed. n = 15 embryos and SEM is shown by bar. p values obtained from Student's t-test. ** denotes p<0.01. …”

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. by Xiaowen Jiang (8291814)

A. We randomly selected 20 mutually exclusive groups of protein complexes that contained exactly five subunits; we mapped the corresponding gene pairs to SINaTRA scores, and plotte... by Alexandra Jacunski (5665486)

“…A SINaTRA cutoff of 0.95 has approximately half of its pairs associated with the same complex; however, a decrease in the cutoff shifts this balance. …”

FA decrease in 5STS impaired participants. by Charlotte Bernard (433013)

Chronic high glucose induces apoptosis and proteasome activities decrease in INS-1E cells. by Christophe Broca (538652)

The decreased permeability caused by phospholipid content in the membrane could drive the emergence of other functions in the protocells. by Wentao Ma (326530)

Adiponectin-induced Irak3 plays an important role in rosiglitazone-mediated decrease of Mcp1. by Maarten Hulsmans (181118)

<i>Pw1</i> deletion does not result in significant decrease in oxytocin production and release. by Anne-Lyse Denizot (3170142)

Blocking C5L2 decreased C5a-primed neutrophils expression of membrane-bound PR3 (mPR3). by Jian Hao (160736)

SHIP-1 decreases NOD2-induced NF-κB activation in epithelial cells. by Claude Condé (150801)

GAS5 levels are decreased in bladder cancer. by Zhihong Liu (112690)

FGF8b decreased GnRH mRNA in GT1-7 cells. by Natasha N. Mott (341221)

Scara5 expression decreased during retinopathy. by Luísa Mendes-Jorge (635136)

“…C: The immunolabeling of paraffin-embedded retinal sections with anti-Scara5 antibody confirmed that Scara5 expression decreased throughout the parenchyma. …”

Resistance to Pap-A correlates with decreases in PS. by Chelsi D. Cassilly (2793433)

Claudin V is decreased following infection with Mtb. by Amanda S. Latham (12093638)

“…<p>Immunofluorescent staining of guinea pig brain tissue for DAPI (blue) and claudin V (cyan) in vessels was performed. Representative images of the frontal cortex (A–D), cerebral nuclei (F–I), brain stem (K–N), thalamus (P–S), and hippocampus (U–X) 15 days post-infection are shown. …”

Sustained expression of radmis results in decreased cell proliferation and increased cell-cycle exit of NSPCs. by Takahito Yumoto (481671)

Clinical and genetic characteristics of 5 patients harboring mutations in the <i>NR5A1</i> gene. by Jana Malikova (615672)

Subjects:

Decreasing Fires in Mediterranean Europe - Fig 5 by Marco Turco (3178641)

Decreased proliferation and increased apoptosis in <i>Mab21l2</i> mutant embryos. by Yohei Saito (180130)

“…Scale bars represent 100 µm (A, D, H, K) and 50 µm (N and P). (R) Quantitative RT-PCR for genes regulating cell proliferation and apoptosis (<i>N-myc</i>, <i>Id2</i>, <i>Cyclin D1</i>, <i>Cyclin D2</i>), marker genes of myocardial differentiation (<i>Anf</i>, <i>Chisel</i>, <i>Mlc2v</i>), genes essential for the development of the trabecular myocardium (<i>Erbb2</i>, <i>Erbb4</i>, <i>Bmp10</i>), genes essential for heart development (<i>Nkx2.5</i>, <i>Gata4</i>), and endocardial transcripts (<i>Flk1</i>, <i>Tie1</i>, <i>Tie2</i>) normalized to <i>Gapdh</i> expression using RNA from dissected hearts of E11.5 WT and <i>Mab21l2</i> mutant (−/−) embryos. …”