GSK-3β inhibition or silencing decreases reporter activity. by Rong Guo (50063)

Stable knockdown of JTB in HCC cells decreases cell apoptosis. by Yun-Peng Liu (108506)

Metronidazole thermogel improves retention and decreases permeation through the skin by Elayne Karine Souto de Melo (12848144)

Speed of misspecified cells decreases with magnitude of differential adhesion, j by Keng-hwee Chiam (623069)

Anandamide decreases locomotor activity and rearing in small open field. by Adriaan W. Bruijnzeel (2605954)

Target specificity, <i>in vivo</i> pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Peter Y. Yu (4281448)

“…The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5.</p><p>Methods and findings</p><p>An <i>in silico</i> fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization. …”

Reverse activation tendency decreases for spikes occurring later in SWRs by Jozsef Csicsvari (82625)

LY5 inhibits STAT3 phosphorylation in lung metastases but does not inhibit lung metastasis formation. by Peter Y. Yu (4281448)

Rat tickling: A systematic review of applications, outcomes, and moderators by Megan R. LaFollette (3911140)

“…The most common method used for tickling was cycling through 15 seconds of tickling and 15 seconds of rest for 2 minutes for 3 to 5 days. Experiments with a control for tickling (N = 22) showed that tickling increases positive vocalization, approach behavior, decreases anxiety measures, improves handling, and in some cases decreases stress hormones. …”

FGF10 dose dependency of the cellular response in E13.5 (black) and E14.5 (blue) epithelium. by Hisako Takigawa-Imamura (3175320)

Fig 5 - by Melissa A. Johnson (3847954)

Fluid loss and hydration in CON (n = 22) and HOT (n = 17) surgeries; Decrease in body mass in kg (A), decrease in body mass in % of total body mass (B), rate of decrease in body ma... by Zehra Palejwala (7507409)

Average changes in (A) spontaneous AP firing rate, (B) ATP and (C) cAMP by decreasing CaMKII activity with KN-93 (high-3 µmol/L, low-0.5 µmol/L), AIP (high-10 µmol/L, low-2 µmol/L), or decreasing calmodulin activity by W-7 (high-50 µmol/L, low-20 µmol/L). by Yael Yaniv (162548)

Average size of church forests in the region is small, 5.42 (+/- 0.34 ha). by Catherine L. Cardelús (6429320)

Upregulation of 5-Hydroxytryptamine Receptor Signaling in Coronary Arteries after Organ Culture by Chun-Yu Deng (293972)

“…<div><p>Background</p><p>5-Hydroxytryptamine (5-HT) is a powerful constrictor of coronary arteries and is considered to be involved in the pathophysiological mechanisms of coronary-artery spasm. …”

Binding affinity determination of ACE2 variants with SARS-CoV-2 Spike. by Stuart A. MacGowan (11326845)

R346K Mutation in the <i>Mu</i> Variant of SARS-CoV‑2 Alters the Interactions with Monoclonal Antibodies from Class 2: A Free Energy Perturbation Study by Filip Fratev (1799740)

“…The <i>Mu</i> variant of SARS-CoV-2 has been recently classified as a variant of interest (VOI) by the World Health Organization (WHO) but limited data are available at the moment. …”

R346K Mutation in the <i>Mu</i> Variant of SARS-CoV‑2 Alters the Interactions with Monoclonal Antibodies from Class 2: A Free Energy Perturbation Study by Filip Fratev (1799740)

“…The <i>Mu</i> variant of SARS-CoV-2 has been recently classified as a variant of interest (VOI) by the World Health Organization (WHO) but limited data are available at the moment. …”

Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space by Charles E. Greif (21728091)

“…The complexes demonstrated submicromolar cytotoxic activity against human breast cancer cells MDA-MB-231 or MDA-MB-468 with IC₅₀’s in the range of 0.4–5.0 μM. Complex <b>2e</b> shows high potency in vitro and decreases 3D-breast cancer mammosphere viability. …”

Tun increases mitochondrial fission, inflammatory cell infiltration, and decreased ER-mitochondria interaction in neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…The decreased expressions of GRP75 (0.5±0.2-fold, p = 0.006767, n = 5) and acyl-CoA synthetase long-chain family member 4 (ASCL4; 0.3±0.1-fold, p<0.001, n = 5) indicate a decreased interaction between ER and mitochondria by Tun. …”