Administration of anatabine inhibits pro-inflammatory cytokines but does not affect the titer of circulating anti-MOG antibodies. by Daniel Paris (286121)

“…B) Anatabine inhibits the production of pro-inflammatory cytokines in the serum of EAE mice. A significant elevation of TNF-α (Mann-Whitney U = 16.5, Z = −2.22, P = 0.026), IL-1β (Mann-Whitney U = 0, Z = −3.506, P<0.001), IL-6 (Mann-Whitney U = 3, Z = −3.271, P<0.001), IFN-γ (Mann-Whitney U = 16.5, Z = −2.219, P = 0.026) and IL-17 (Mann-Whitney U = 7, Z = −2.958, P = 0.003) was observed in the serum of EAE mice (placebo) compared to control non-immunized mice. …”

Image_2_The Increased Risk of Thyroid Cancer-Specific Mortality With Tumor Size in Stage IVB Patients.PNG by Junyi Zhang (290426)

“…</p><p>Methods: One thousand three hundred and forty-five patients (620 males and 725 females) with initial distant metastasis over 55 years between 2004 and 2016 from Surveillance, Epidemiology, and End Results databases were investigated, with a median follow-up time of 23 months [interquartile range (IQR), 5–56 months] and a median age of 70 years (IQR, 63–77 years). …”

Neuroprotection by CPE-ΔN involves AKT and ERK signaling pathways. by Xiao-Yan Qin (666512)

“…Data shown represent one experiment. n = 4/group (A); 5/group (B); 4/group (C); 5/group (D). Values are mean ± SEM, one-way ANOVA followed by Tukey test, *p<0.05.…”

General participant characteristics. by Josephine Grandt (21512356)

“…GOBP analyses revealed an increase in pro-inflammatory and pro-fibrotic genes in NAFLD and cirrhosis, as well as a decrease in genes related to metabolism. Data were made browsable using two web-based apps. …”

Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools by Jun Ding (80820)

“…As expected, mothers and offspring share all homoplasmies but a lesser proportion of heteroplasmies. Both homoplasmies and heteroplasmies show 5-fold higher transition/transversion ratios than variants in nuclear DNA. …”

Video_1_Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion.MP4 by Peijun Jia (11334594)

“…The results showed that the BBB leakage was associated with a decrease in TJ protein expression and an increase in MMP-9 activity and AQP4 expression on day 3 in the c-ICH model compared with that on day 5 in the b-ICH model. …”

Supplementary Material for: Neuronal Nitric Oxide Synthase Inhibition Prevents Cerebral Palsy following Hypoxia-Ischemia in Fetal Rabbits: Comparison between JI-8 and 7-Nitroindazo... by Yu L. (3691228)

“…JI-8 treatment resulted in a significant decrease in NOS activity (39%) in fetal brain homogenates acutely after HI, without affecting maternal blood pressure and heart rate. …”

TLR7 Influences Germinal Center Selection in Murine SLE by Alexis Boneparth (707054)

“…In addition, although all chimeras preferentially selected 3H9/Vκ5 encoded B cells into the germinal center and plasma cell compartments, 3H9 male <i>Yaa</i> chimeras had a more diverse repertoire and positively selected the 3H9/Vκ5-48/Jκ4 pair that confers high affinity anti-cardiolipin activity. …”

DataSheet2_The Involvement of TRIB3 and FABP1 and Their Potential Functions in the Dynamic Process of Gastric Cancer.ZIP by Songyi Liu (11589508)

“…Hp infection was significantly associated with the decreased expression of TRIB3 and FABP1. In addition, the diagnostic efficiency of the combination of these two indicators to diagnose EGC was higher than that of a single indicator. …”

Data_Sheet_1_Highly Efficient Deep Blue Luminescence of 2-Coordinate Coinage Metal Complexes Bearing Bulky NHC Benzimidazolyl Carbene.pdf by Rasha Hamze (1987576)

“…All the complexes emit in the deep blue region (~430 nm) with relatively narrow spectra (full width at half maximum = 44 nm, 2,300 cm⁻¹) characterized by vibronic fine structure in nonpolar media (methylcyclohexane at room temperature), and with high photoluminescence quantum yields (Φ_PL > 80%) and radiative rate constants (k_r ~ 7.8 × 10⁵ s⁻¹). The luminescence is solvatochromic, undergoing a red-shift in a polar solvent (CH₂Cl₂) at room temperature that are accompanied by a decrease in quantum yields (Φ_PL < 23%) and radiative rate constants (k_r < 4.0 × 10⁴ s⁻¹), whereas the non-radiative rate constants remain nearly constant (k_nr ~ 1.0 × 10⁵ s⁻¹). …”

Pcl3 promotes ESC self-renewal. by Julie Hunkapiller (177548)

“…Graph represents average expression from 3–6 different clones. (B) A portion of cells transduced with <i>Pcl3</i> shRNA, but not scramble shRNA, are larger, flatter, and less dense, signifying a decrease in ESC cell morphology. …”

Image_1_The Increased Risk of Thyroid Cancer-Specific Mortality With Tumor Size in Stage IVB Patients.PNG by Junyi Zhang (290426)

“…</p><p>Methods: One thousand three hundred and forty-five patients (620 males and 725 females) with initial distant metastasis over 55 years between 2004 and 2016 from Surveillance, Epidemiology, and End Results databases were investigated, with a median follow-up time of 23 months [interquartile range (IQR), 5–56 months] and a median age of 70 years (IQR, 63–77 years). …”

Image_1_Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood Infusion.jpeg by Peijun Jia (11334594)

“…The results showed that the BBB leakage was associated with a decrease in TJ protein expression and an increase in MMP-9 activity and AQP4 expression on day 3 in the c-ICH model compared with that on day 5 in the b-ICH model. …”

Data_Sheet_1_Chinese Home-Based Cardiac Rehabilitation Model Delivered by Smartphone Interaction Improves Clinical Outcomes in Patients With Coronary Heart Disease.PDF by Jing Ma (24574)

“…</p><p>Conclusions: The Chinese HBCR model using smartphone interaction is a safe and effective approach to decrease cardiovascular risks of patients with CHD and improve patients' wellness.…”

Trends in spatial patterns of heavy metal deposition on national park service lands along the Red Dog Mine haul road, Alaska, 2001–2006 by Peter N. Neitlich (4034300)

“…Cd decreased significantly by 38% immediately adjacent to the road (0–100m), had an 89% probability of a small decrease 100–2000 m from the road, and showed moderate probabilities (56–71%) for increase at greater distances. …”

Renal phenotype of male Akita mice by genetic background. by Jae-Hyung Chang (327325)

“…<p>NR: not reported, ND: Not detected,</p>*<p>Compared to strain matched non-diabetic controls,</p>†<p>Animal models of diabetic complications consortium (ADMCC) criteria: >10-fold increase in albuminuria, >50% decrease in GFR over the lifetime of the animal, Advanced mesangial expansion, Arteriolar hylanosis, >50% increase in GBM thickness, Tubulointerstitial fibrosis,</p>**<p>variable (see text for discussion),</p>‡<p>Increased BUN at 30–40 weeks of age, References: <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Breyer1" target="_blank">[3]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Gurley1" target="_blank">[4]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Gurley2" target="_blank">[5]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Susztak1" target="_blank">[13]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Brosius1" target="_blank">[30]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Hong1" target="_blank">[35]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Haseyama1" target="_blank">[48]</a>.…”

Sequence conservation in hemagglutinin groups and subtypes. by Nicola Clementi (174058)

“…*Recombinant HA from H1N1 A/South Carolina/1/1918 pandemic strain was previously shown to be bound by PN-SIA28 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028001#pone.0028001-Burioni2" target="_blank">[19]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028001#pone.0028001-Burioni3" target="_blank">[20]</a>; analogously, recombinant HA from H5N1 A/Cygnus Olor/Italy/742/2005 was recognized by PN-SIA28 (data not shown). # H1N1 A/New Caledonia/20/1999 was previously shown to be neutralized by PN-SIA28 as Fab fragment <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028001#pone.0028001-Burioni2" target="_blank">[19]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0028001#pone.0028001-Burioni3" target="_blank">[20]</a>.…”

Roles of individual genetic factors during repair of DSBs with non-cohesive ends generated by co-expression of I-SceI with Trex2. by Nicole Bennardo (93380)

“…(B) Trex2 expression causes a decrease in HDR in cells deficient in Nbs1 and Brca1, but an increase in HDR in cells deficient in Xrcc4 and Msh2. …”

Robotic Left Upper Lobectomy by Stephanie G. Worrell (4876525)

“…She then had a completion robotic lobectomy with mediastinal lymph node dissection of stations 5, 6, 7, and L9. …”

Table_1_Is it time for class I recommendation for sodium-glucose cotransporter-2 inhibitors in heart failure with mildly reduced or preserved ejection fraction?: An updated systema... by Sukrit Treewaree (14577911)

“…Significant change was observed in the KCCQ-clinical summary score compared to baseline (mean difference: 1.33, 95%CI: 1.31–1.35), and meaningful improvement in QoL was shown across all 3 types of increase in KCCQ score ≥ 5 points.…”