Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glio... by Qingqing Zhou (3801922)

“…The most potent inhibitors (IC₅₀ ≤ 50 nM) significantly decreased viability, clonogenic survival, migration, and invasion of glioblastoma cells. …”

The time-dependent currents in <i>Mytilus galloprovincialis</i> hemocytes are modulated by the osmotic pressure. by Monica Bregante (3391766)

“…D) The hyperosmotic bath solution determines a decrease of the steady-state current elicited by V = -100 mV (left bar) without altering the capacitance of the cells (right bar). …”

DataSheet_1_Effects of low-calorie and different weight-maintenance diets on IgG glycome composition.docx by Helena Deriš (13841866)

“…The most significant alteration of the IgG N-glycome was present 8 weeks after the subjects underwent an LCD, a statistically significant decrease of agalactosylated and the increase of sialylated N glycans. …”

C-phycocyanin protects cells from free radical-mediated lipid peroxidation (LPO) induced by oxalate. by Shukkur M. Farooq (300564)

“…Band intensity of HEL is prominent in oxalate-alone-treated cells (G2) at 72 kDa and 50 kDa compared to control MDCK cells (G1), whereas oxalate+CP cells (G3) showed decreased HEL band intensity relative to oxalate-treated cells (G2). …”

Response to NLC for 1 122 native plant species with significant null models. by Kaixuan Pan (11714457)

“…All mean values are means ± SE.</p>…”

Responses of cells expressing various γ subunits to different concentrations of agonist. by Mariangela Chisari (257345)

“…<p><i>A.</i> M3-CHO cells expressing αq-CFP, YFP-γ (as indicated) and PH-mCh were imaged as mentioned in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0007797#s4" target="_blank">Methods</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0007797#pone.0007797.s006" target="_blank">Text S1</a>. …”

Phospholamban Modulates the Functional Coupling between Nucleotide Domains in Ca-ATPase Oligomeric Complexes in Cardiac Sarcoplasmic Reticulum by Linda T. L. Chen (2384860)

“…Accompanying the phosphorylation of PLB, neighboring Ca-ATPase polypeptide chains exhibit a 4 ± 2 Å decrease in the proximity between FITC sites within the N-domain and a 9 ± 3 Å increase in the proximity between IAF sites within P-domains. …”

Image1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.tif by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

WIKI4 inhibits the functional outcomes of Wnt/ß-catenin signaling. by Richard G. James (114424)

“…(<b>C</b>) Treatment with WIKI4 prevents the decrease in co-expression of markers of undifferentiated hESCs following Wnt3A stimulus. hESCs were stimulated with the indicated treatments and expression of GCTM2 and CD9 was assessed by flow cytometry following six days of treatment. …”

Effects of the activation and inhibition of NOTCH signalling on spinal cord progenitor cell proliferation and neuronal generation. by Barbara Hämmerle (36261)

“…Higher magnification of a single optical section (5 µm) of the boxed region of F showing two double labelled cells. …”

Proteomic Biomarkers for Ageing the Mosquito <em>Aedes aegypti</em> to Determine Risk of Pathogen Transmission by Leon E. Hugo (252728)

“…Using the 2-D Difference Gel Electrophoresis (2-D DIGE) procedure, we investigated the abundance of up to 898 proteins from the Yellow Fever and dengue virus vector, <i>Aedes aegypti</i>, during ageing. By applying a mixed-effects model of protein expression, we identified five common patterns of abundance change during ageing and demonstrated an age-related decrease in variance for four of these. …”

Significantly enriched pathways after infection by EV-D94 or EV-D68 in respiratory and intestinal tissues. by Ines Cordeiro Filipe (5849144)

“…<p><b>A)</b>. Genes with average log2 fold change increase/decrease of 0.5 versus the mock were considered for pathway analysis. …”

Solution X-ray Absorption Fine Structure Study of the Eu²⁺ and Sr²⁺ Ions:  Unexpected Solvent and Metal Ion Dependencies of the Solvation Numbers by Gilles Moreau (3042738)

“…For both Eu²⁺ and Sr²⁺ ions, a decrease in coordination number (<i>N</i>) and metal-to-solvent distances was found along the increasingly solvating MeCN < H₂O ≪ DMF < DMSO solvent series:  for strontium, <i>N</i> = 8 with [Sr(MeCN)₈]²⁺ (2.665(6) Å) and [Sr(H₂O)₈]²⁺ (2.600(3) Å) and <i>N</i> = 7 with [Sr(DMF)₇]²⁺ (2.555(5) Å) and [Sr(DMSO)₇]²⁺ (2.540(7) Å); for europium(II), <i>N</i> = 8 with [Eu(MeCN)₈]²⁺ (2.640(4) Å), <i>N</i> = 7 with [Eu(H₂O)₇]²⁺ (2.584(5) Å), and <i>N</i> = 6 with [Eu(DMF)₆]²⁺ (2.541(3) Å) and by extrapolation [Eu(DMSO)₆]²⁺ (2.525 Å). …”

Table1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.docx by Xiaozhen Huang (5858690)

“…Background<p>Isolated growth hormone deficiency type II (IGHD II) is an autosomal dominant disorder characterized by a GH1 gene variant resulting in a significant reduction in growth hormone (GH) secretion and a subsequent decrease of plasma insulin-like growth factor 1 (IGF-1) levels and eventual growth impairment.…”

Phospholamban Modulates the Functional Coupling between Nucleotide Domains in Ca-ATPase Oligomeric Complexes in Cardiac Sarcoplasmic Reticulum by Linda T. L. Chen (2384860)

“…Accompanying the phosphorylation of PLB, neighboring Ca-ATPase polypeptide chains exhibit a 4 ± 2 Å decrease in the proximity between FITC sites within the N-domain and a 9 ± 3 Å increase in the proximity between IAF sites within P-domains. …”

Data_Sheet_1_Neural mechanisms of expert persuasion on willingness to pay for sugar.pdf by Ioannis Ntoumanis (11904629)

“…We recently showed that a healthy eating call by a health expert can significantly decrease the willingness to pay (WTP) for sugar-containing food. …”

Cell wall components are altered in the <i>mar1Δ</i> cell wall. by Shannon K. Esher (720288)

“…All other comparisons, not significant (C) Cell wall genes are differentially regulated in <i>mar1Δ</i>. A concentration of 10⁷ cells/ml in 25 ml YPD (30°C) or TC (37°C) were incubated for 1.5 hours, followed by RNA extraction and cDNA synthesis. …”

Image_1_Chemerin and PEDF Are Metaflammation-Related Biomarkers of Disease Activity and Obesity in Rheumatoid Arthritis.pdf by Barbara Tolusso (146649)

“…Moreover, after low-calories diet, RA with low-moderate disease activity reaching BMI reduction ≥5% (62.6%) at 6 months had significant decrease of PEDF (p < 0.05) and Chemerin (p < 0.05) plasma values, in parallel with the improvement in disease activity.…”

Table1_Effects of shading on morphology, photosynthesis characteristics, and yield of different shade-tolerant peanut varieties at the flowering stage.docx by Jing Wang (6206297)

“…Shade stress led to decreased dry-matter accumulation, reduced weight of 100 fruits and kernels, and a significant decline in yield in the shade-sensitive cultivars. …”

Minimally Invasive Cardiac Surgery versus Sternotomy - Pain Investigation by Juliana Fernandes Silva (7292450)

“…In addition, patients subjected to MI procedure had a significant decrease in pain intensity from the third to the seventh PO days (p = 0.001). …”