Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Decreased Tks5 expression results in neural crest-derived defects. by Danielle A. Murphy (212554)

“…<p>(A–B) Melanophores within the trunk region above the yolk sac extension in control MO-injected and Tks5 MO-injected embryos were qualitatively (A) and quantitatively (B) analyzed. n = 15 embryos and SEM is shown by bar. p values obtained from Student's t-test. ** denotes p<0.01. …”

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. by Xiaowen Jiang (8291814)

A. We randomly selected 20 mutually exclusive groups of protein complexes that contained exactly five subunits; we mapped the corresponding gene pairs to SINaTRA scores, and plotte... by Alexandra Jacunski (5665486)

“…A SINaTRA cutoff of 0.95 has approximately half of its pairs associated with the same complex; however, a decrease in the cutoff shifts this balance. …”

FA decrease in 5STS impaired participants. by Charlotte Bernard (433013)

Physiological characterization of rice <i>m167</i> plants. by Xuexia Wang (3701098)

Stat1 prevents the decrease of p27^Kip1 by activated Ras. by Shuo Wang (143908)

Heterozygous and homozygous loss of TCF4 leads to dendritic spine density decrease in the adult brain. by Sophie Crux (5439410)

“…In stratum radiatum of CA1 (right) <i>Tcf4</i>^<i>fl/fl</i> display decreased spine density compared to WT; n = 6 mice *p < 0.05. …”

Chronic high glucose induces apoptosis and proteasome activities decrease in INS-1E cells. by Christophe Broca (538652)

Adiponectin-induced Irak3 plays an important role in rosiglitazone-mediated decrease of Mcp1. by Maarten Hulsmans (181118)

<i>Pw1</i> deletion does not result in significant decrease in oxytocin production and release. by Anne-Lyse Denizot (3170142)

CaMKIIδ deletion does not decrease VSMC proliferation or endothelial expression of VCAM-1 or CD54 (ICAM-1). by Jason A. Scott (443501)

Blocking C5L2 decreased C5a-primed neutrophils expression of membrane-bound PR3 (mPR3). by Jian Hao (160736)

Accumulation of mononuclear leukocyte and CD4⁺ and CD8⁺ T cells is decreased in the brains of infected α_D ^-/- mice. by Isaclaudia G. de Azevedo-Quintanilha (8173734)

Decreased chemokine and chemokine receptor gene transcription in TREM2-KO mice after stroke. by Matthias W. Sieber (106521)

Decreased chondrocytes proliferation, shortening of pre-hypertrophic and hypertrophic zone in BMP signaling deficient mice. by Bettina Keller (231677)

“…(G–I) BrdU staining revealed a decreased proliferation rate in <i>Smad1^cKO/cKO;Smad5^+/−</i> compared to WT control (P<0.02).…”

SHIP-1 decreases NOD2-induced NF-κB activation in epithelial cells. by Claude Condé (150801)

Elimination of persistent <i>P</i>. <i>c</i>. <i>chabaudi</i> infection decreases memory T cell numbers in <i>Icos</i>^-/- mice. by Leah E. Latham (8781863)

AMPK phosphorylation and AC5 and AC6 gene expression in hearts from WT and AMPKα2-/- mice following TAC. by Anne Garnier (130125)

Subjects:

Maintenance of a single Zeb2 wt allele rescues PB cytopenia and severe differentiation defects in Zeb1/2 DKO HSPCs. by Jueqiong Wang (11467505)