Preliminary Evidence for Cell Membrane Amelioration in Children with Cystic Fibrosis by 5-MTHF and Vitamin B12 Supplementation: A Single Arm Trial by Cinzia Scambi (243788)

“…We evaluated RBCs membrane lipid composition, membrane protein oxidative damage, cation content, cation transport pathways, plasma and RBCs folate levels and plasma homocysteine levels at baseline and after 24 weeks of 5-MTHF and vitamin B12 supplementation. In CF children, 5-MTHF and vitamin B12 supplementation (i) increased plasma and RBC folate levels; (ii) decreased plasma homocysteine levels; (iii) modified RBC membrane phospholipid fatty acid composition; (iv) increased RBC K⁺ content; (v) reduced RBC membrane oxidative damage and HSP70 membrane association.…”

<em>RAD50</em> Is Required for Efficient Initiation of Resection and Recombinational Repair at Random, γ-Induced Double-Strand Break Ends by Jim Westmoreland (260234)

“…Unlike for enzymatically induced site-specific DSBs, little is known about processing of random “dirty-ended” DSBs created by DNA damaging agents such as ionizing radiation. Here we present a novel system for monitoring early events in the repair of random DSBs, based on our finding that single-strand tails generated by resection at the ends of large molecules in budding yeast decreases mobility during pulsed field gel electrophoresis (PFGE). …”

Treatment with APB5, but not APA5 attenuates pulmonary fibrosis in BLM-treated mice. by Masami Kishi (6167105)

“…<p>BLM was injected subcutaneously with a mini-osmotic pump for 7 days. APA5, APB5, and IgG as a control were injected intraperitoneally every other day from the start on Day 0 to sacrifice on Day 28. …”

LV function and geometry: Exercise cohort. by Stephanie L. Samani (17896610)

“…Additionally, miR-22 and miR-30e decreased with exercise and mapped to a localized inflammatory process, the inflammasome (NLRP-3, whereby a 2-fold decrease in NLRP-3 mRNA occurred with exercise (p < 0.05).…”

S1 Graphical abstract - by Stephanie L. Samani (17896610)

“…Additionally, miR-22 and miR-30e decreased with exercise and mapped to a localized inflammatory process, the inflammasome (NLRP-3, whereby a 2-fold decrease in NLRP-3 mRNA occurred with exercise (p < 0.05).…”

Table_5_PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells.DOCX by David K. Dansu (12252515)

“…This analysis identified a similar number of peptides in the two subcellular fractions and a total number of 57 proteins with statistically decreased symmetric methylation of arginine residues in the CRISPR-PRMT5 knockdown compared to control. …”

Immunometabolic remodeling is associated with proinflammatory eicosanoid signaling. by Jeffrey M. Collins (5753942)

Increase in conjunctival AQP5 and MUC5AC expression in rabbits after surgery. by Dhruva Bhattacharya (4576591)

“…The MUC5AC protein expression followed similar pattern of upregulation, demonstrating a synchronous relationship with AQP5. …”

Image_3_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.PNG by Yuan Huang (79836)

“…Meanwhile, AQP4 and COX5A are detected by real-time quantitative PCR (qRT-PCR) and western blot (WB). …”

Table_6_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.XLS by Yuan Huang (79836)

“…Meanwhile, AQP4 and COX5A are detected by real-time quantitative PCR (qRT-PCR) and western blot (WB). …”

Table_4_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.XLSX by Yuan Huang (79836)

“…Meanwhile, AQP4 and COX5A are detected by real-time quantitative PCR (qRT-PCR) and western blot (WB). …”

Table_3_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.XLS by Yuan Huang (79836)

“…Meanwhile, AQP4 and COX5A are detected by real-time quantitative PCR (qRT-PCR) and western blot (WB). …”

Image_1_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.JPEG by Yuan Huang (79836)

“…Meanwhile, AQP4 and COX5A are detected by real-time quantitative PCR (qRT-PCR) and western blot (WB). …”

Image_2_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.JPEG by Yuan Huang (79836)

“…Meanwhile, AQP4 and COX5A are detected by real-time quantitative PCR (qRT-PCR) and western blot (WB). …”

Table_2_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.XLS by Yuan Huang (79836)

“…Meanwhile, AQP4 and COX5A are detected by real-time quantitative PCR (qRT-PCR) and western blot (WB). …”

Table_1_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.XLSX by Yuan Huang (79836)

“…Meanwhile, AQP4 and COX5A are detected by real-time quantitative PCR (qRT-PCR) and western blot (WB). …”

Image_4_The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.JPEG by Yuan Huang (79836)

“…Meanwhile, AQP4 and COX5A are detected by real-time quantitative PCR (qRT-PCR) and western blot (WB). …”

Table_2_Move for Life an intervention for inactive adults aged 50 years and older: a cluster randomised feasibility trial.DOCX by Catherine B. Woods (10517765)

“…Background<p>Move for Life (MFL) is a theory-informed intervention that was developed to augment established physical activity (PA) programmes and enable inactive adults aged 50 years and older to be more active. This study examined the feasibility of MFL and sought to provide evidence of its potential for improving PA and associated health outcomes.…”

Table_1_Move for Life an intervention for inactive adults aged 50 years and older: a cluster randomised feasibility trial.DOCX by Catherine B. Woods (10517765)

“…Background<p>Move for Life (MFL) is a theory-informed intervention that was developed to augment established physical activity (PA) programmes and enable inactive adults aged 50 years and older to be more active. This study examined the feasibility of MFL and sought to provide evidence of its potential for improving PA and associated health outcomes.…”

RSV inhibited the interaction of klf5 with c-Myc by inducing klf5 phosphorylation. by Hui Yang (91136)

“…<p>Cultured HEK293 cells were incubated with 20 μM RSV for different times, and then subjected to western blot analysis. (A) Cell extracts were immunoprecipitated with antibody to phosphoserine and immunoblotted with antibody to klf5. …”