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we decrease » _ decrease (Expand Search), nn decrease (Expand Search), teer decrease (Expand Search)
wt decrease » _ decrease (Expand Search), nn decrease (Expand Search), awd decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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14641
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14642
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14644
Degradation of a VX Analogue: First Organometallic Reagent To Promote Phosphonothioate Hydrolysis Through Selective P−S Bond Scission
Published 2008“…We report the first case of a metal complex that degrades a neurotoxin mimic under extremely mild conditions (pH 6.8, room temperature). …”
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14645
Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases
Published 2022“…CARM1 (coactivator-associated arginine methyltransferase 1), which belongs to type I PRMTs (protein arginine methyltransferases), is a potential therapeutic target for treatment of multiple cancers. In this study, we first identified several hit compounds against CARM1 by structure-based virtual screening (IC<sub>50</sub> = 35.51 ± 6.68 to 68.70 ± 8.12 μM) and then carried out chemical structural optimizations, leading to six compounds with significantly improved activities targeting CARM1 (IC<sub>50</sub> = 18 ± 2 to 107 ± 6 nM). …”
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14646
Image_5_Measurement of the burdens of neonatal disorders in 204 countries, 1990–2019: a global burden of disease-based study.jpg
Published 2024“…Among 21 regions, the ASIR trend had the largest increase in Central Latin America (EAPC = 0.42, 95%CI = 0.33–0.50). Conversely, the ASDR and ASR-DALYs experienced the largest decrease in Central Europe (EAPC = −5.10, 95%CI = −5.28 to 4.93) and East Asia (EAPC = −4.07, 95%CI = −4.41 to 3.73), respectively. …”
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14647
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14648
Registration-based receptive field comparisons show a quantitative match between SAILnet and macaque V1 RF shapes.
Published 2013“…<p>(<b>A</b>) For illustration purposes, we show 100 of the 250 macaque V1 receptive fields (courtesy of D. …”
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14649
Temporal trend of ∑DDT levels in osprey eggs in different study areas and all areas combined (lower graph).
Published 2024“…∑DDT concentrations decreased significantly in the whole dataset (annual decrease 8.1%) and in all study areas (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0308227#pone.0308227.g015" target="_blank">Fig 15</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0308227#pone.0308227.t002" target="_blank">Table 2</a>). …”
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14650
Image5_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF
Published 2024“…Our search identified that miR-204-5p and miR-211-5p (miR-204/211), two broadly conserved miRNAs, share PDIA1 as a potential target. …”
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14651
Table_1_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX
Published 2020“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
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14652
Table_2_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX
Published 2020“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
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14653
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14654
Image_2_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.JPEG
Published 2020“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
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14655
Table_3_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX
Published 2020“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
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14656
Table_5_Causal relationship between telomere length and risk of intracranial aneurysm: a bidirectional Mendelian randomization study.XLSX
Published 2024“…</p>Conclusion<p>There may exist a potential correlation between longer telomere length and a decreased likelihood of intracranial aneurysms within the European population. …”
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14657
Image_1_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.JPEG
Published 2020“…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
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14658
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14659
Table_5_Dysregulated miRNAome and Proteome of PPRV Infected Goat PBMCs Reveal a Coordinated Immune Response.XLSX
Published 2018“…These include miR-664, miR-2311, miR-2897, miR-484, miR-2440, miR-3533, miR-574, miR-210, miR-21-5p, and miR-30. miR-664 and miR-484 with proviral and antiviral activities, respectively, were upregulated in PPRV infected PBMCs. miR-210 that inhibits apoptosis was downregulated. miR-21-5p that decreases the sensitivity of cells to the antiviral activity of IFNs and miR-30b that inhibits antigen processing and presentation by primary macrophages were downregulated, indicative of a strong host response to PPRV infection. miR-21-5p was found to be inhibited on IPA upstream regulatory analysis of RNA-sequencing data. …”
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14660
Image2_Osteogenesis-Related Long Noncoding RNA GAS5 as a Novel Biomarker for Osteonecrosis of Femoral Head.TIFF
Published 2022“…In addition, the lncRNA GAS5 expression level significantly decreased in the ONFH rat model group.…”