Showing 14,641 - 14,660 results of 106,665 for search '(( 50 ((we decrease) OR (mean decrease)) ) OR ( 5 ((wt decrease) OR (a decrease)) ))', query time: 1.60s Refine Results
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  2. 14642
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  4. 14644

    Degradation of a VX Analogue: First Organometallic Reagent To Promote Phosphonothioate Hydrolysis Through Selective P−S Bond Scission by Louis Y. Kuo (1915309)

    Published 2008
    “…We report the first case of a metal complex that degrades a neurotoxin mimic under extremely mild conditions (pH 6.8, room temperature). …”
  5. 14645

    Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases by Xiao Li (107004)

    Published 2022
    “…CARM1 (coactivator-associated arginine methyltransferase 1), which belongs to type I PRMTs (protein arginine methyltransferases), is a potential therapeutic target for treatment of multiple cancers. In this study, we first identified several hit compounds against CARM1 by structure-based virtual screening (IC<sub>50</sub> = 35.51 ± 6.68 to 68.70 ± 8.12 μM) and then carried out chemical structural optimizations, leading to six compounds with significantly improved activities targeting CARM1 (IC<sub>50</sub> = 18 ± 2 to 107 ± 6 nM). …”
  6. 14646

    Image_5_Measurement of the burdens of neonatal disorders in 204 countries, 1990–2019: a global burden of disease-based study.jpg by Juan Xin (5745998)

    Published 2024
    “…Among 21 regions, the ASIR trend had the largest increase in Central Latin America (EAPC = 0.42, 95%CI = 0.33–0.50). Conversely, the ASDR and ASR-DALYs experienced the largest decrease in Central Europe (EAPC = −5.10, 95%CI = −5.28 to 4.93) and East Asia (EAPC = −4.07, 95%CI = −4.41 to 3.73), respectively. …”
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  8. 14648

    Registration-based receptive field comparisons show a quantitative match between SAILnet and macaque V1 RF shapes. by Joel Zylberberg (340947)

    Published 2013
    “…<p>(<b>A</b>) For illustration purposes, we show 100 of the 250 macaque V1 receptive fields (courtesy of D. …”
  9. 14649

    Temporal trend of ∑DDT levels in osprey eggs in different study areas and all areas combined (lower graph). by Matti Viluksela (321291)

    Published 2024
    “…∑DDT concentrations decreased significantly in the whole dataset (annual decrease 8.1%) and in all study areas (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0308227#pone.0308227.g015" target="_blank">Fig 15</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0308227#pone.0308227.t002" target="_blank">Table 2</a>). …”
  10. 14650

    Image5_Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204.TIF by Leonardo Y. Tanaka (18306715)

    Published 2024
    “…Our search identified that miR-204-5p and miR-211-5p (miR-204/211), two broadly conserved miRNAs, share PDIA1 as a potential target. …”
  11. 14651

    Table_1_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX by Chaoqin Shen (3763807)

    Published 2020
    “…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
  12. 14652

    Table_2_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX by Chaoqin Shen (3763807)

    Published 2020
    “…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
  13. 14653
  14. 14654

    Image_2_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.JPEG by Chaoqin Shen (3763807)

    Published 2020
    “…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
  15. 14655

    Table_3_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.XLSX by Chaoqin Shen (3763807)

    Published 2020
    “…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
  16. 14656

    Table_5_Causal relationship between telomere length and risk of intracranial aneurysm: a bidirectional Mendelian randomization study.XLSX by Bangjie Xu (18133135)

    Published 2024
    “…</p>Conclusion<p>There may exist a potential correlation between longer telomere length and a decreased likelihood of intracranial aneurysms within the European population. …”
  17. 14657

    Image_1_ALKBH4 Functions as a Suppressor of Colorectal Cancer Metastasis via Competitively Binding to WDR5.JPEG by Chaoqin Shen (3763807)

    Published 2020
    “…Mechanistically, CO-IP and ChIP assays indicated that ALKBH4 competitively bound WDR5 (a key component of histone methyltransferase complex) and decreased H3K4me3 histone modification on the target genes including MIR21.…”
  18. 14658
  19. 14659

    Table_5_Dysregulated miRNAome and Proteome of PPRV Infected Goat PBMCs Reveal a Coordinated Immune Response.XLSX by Alok Khanduri (5999219)

    Published 2018
    “…These include miR-664, miR-2311, miR-2897, miR-484, miR-2440, miR-3533, miR-574, miR-210, miR-21-5p, and miR-30. miR-664 and miR-484 with proviral and antiviral activities, respectively, were upregulated in PPRV infected PBMCs. miR-210 that inhibits apoptosis was downregulated. miR-21-5p that decreases the sensitivity of cells to the antiviral activity of IFNs and miR-30b that inhibits antigen processing and presentation by primary macrophages were downregulated, indicative of a strong host response to PPRV infection. miR-21-5p was found to be inhibited on IPA upstream regulatory analysis of RNA-sequencing data. …”
  20. 14660

    Image2_Osteogenesis-Related Long Noncoding RNA GAS5 as a Novel Biomarker for Osteonecrosis of Femoral Head.TIFF by Guanzhi Liu (11016411)

    Published 2022
    “…In addition, the lncRNA GAS5 expression level significantly decreased in the ONFH rat model group.…”