Video1_The mechanisms of potassium loss in acute myocardial ischemia: New insights from computational simulations.AVI by Jose M. Ferrero (6705797)

“…In order to investigate these mechanisms, we developed a novel computational model of acute myocardial ischemia which couples a) an electrophysiologically detailed human cardiomyocyte model that incorporates modifications to account for ischemia-induced changes in transmembrane currents, with b) a model of cardiac tissue and extracellular K⁺ transport. …”

Data_Sheet_2_The burden of epilepsy in the People’s Republic of China from 1990 to 2019: epidemiological trends and comparison with the global burden of epilepsy.PDF by Yun Shu (2016445)

“…However, Disability-Adjusted Life Years (DALY) decreased notably, and the proportion of Years of Life Lost (YLL) decreased from 62.73 to 39.03%. …”

Preparation of Heat-Denatured Macroaggregated Albumin for Biomedical Applications Using a Microfluidics Platform by Tullio V. F. Esposito (8900282)

“…These microparticles are formed by heat-denaturing albumin in a bulk solution, making it very challenging to control the size and dispersity of the preparations (coefficient of variation, CV, ∼50%). In this work, we developed an integrated microfluidics platform to create more tunable and precise MAA particles, the so-called microfluidic-MAA (M2A2). …”

<i>In-silico</i> identification of fingerprint of pyrazolyl sulfonamide responsible for inhibition of <i>N</i>-myristoyltransferase using Monte Carlo method with index of ideality... by Ashwani Kumar (55732)

“…In the present manuscript, we have developed robust and reliable QSAR models by using the balance of correlation method in CORAL software. …”

Table1_Systematic Review and Meta-Analysis of Renin–Angiotensin–Aldosterone System Blocker Effects on the Development of Cardiovascular Disease in Patients With Chronic Kidney Dise... by Katsunori Yanai (5447384)

“…Among the RAAS blockers, mineralocorticoid receptor antagonists significantly decreased cardiovascular events in pre-dialysis or on-dialysis patients with CKD (four studies; OR, 0.60; 95%CI, 0.50 to 0.73, p < 0.0001). …”

Data_Sheet_1_Patient satisfaction and outcomes of crisis resolution home treatment for the management of acute psychiatric crises: a study during the COVID-19 pandemic in Madrid.do... by Irene Moreno-Alonso (16931331)

“…However, CRHT did not achieve a statistically significant decrease in caregiver burden. Regarding the satisfaction of the patients with the attention and care received, an average score of 47.72/50 was obtained.…”

Table_1_School-Based Prevention Targeting Non-Suicidal Self-injury: A Pilot Study.docx by Imke Baetens (5195765)

“…Regarding secondary outcome measures, we also observed increased emotional awareness in both groups. …”

The Protein <i>O</i>-glucosyltransferase Rumi Modifies Eyes Shut to Promote Rhabdomere Separation in <i>Drosophila</i> by Amanda R. Haltom (664189)

“…The intracellular accumulation of Eys and the IRS defect worsen in <i>rumi</i> mutants raised at a higher temperature, and are accompanied by a ∼50% decrease in the total level of Eys. Moreover, removing one copy of an endoplasmic reticulum chaperone enhances the rhabdomere attachment in <i>rumi</i> mutant animals. …”

Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis by Joy E. Kirkpatrick (5435834)

“…Our studies indicate that ML324 also inhibits KDM4B (IC50: 4.9 μM), and decreases the pro-inflammatory cytokine response to an Aa-LPS challenge in vitro. …”

A Novel Role for Wnt/Ca²⁺ Signaling in Actin Cytoskeleton Remodeling and Cell Motility in Prostate Cancer by Qin Wang (109812)

“…A quantitative analysis of the expression of Wnt5A protein in human tissue arrays, containing 600 prostate tissue cores, showed >50% increase in malignant compared to benign cores (<em>p</em><0.0001). …”

Discovery and Validation of New Potential Biomarkers for Early Detection of Colon Cancer by Xavier Solé (40875)

“…</p><p>Impact</p><p>The use of a cheap serum test for colon cancer screening should improve its participation rates and contribute to decrease the burden of this disease.</p></div>…”

Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells by Antoine Nougairede (5649739)

“…The wild-type and two re-encoded viruses were passaged 50 times either in primate or insect cells, or in each cell line alternately. …”

Data_Sheet_1_Higher frailty levels are associated with lower cognitive test scores in a multi-country study: evidence from the study on global ageing and adult health.docx by Rosa Estela García-Chanes (16002533)

“…</p>Results<p>A total of 30,674 participants aged 50 years or older were included. There was an association between frailty levels and cognitive performance. …”

BX-C genes control DT tube tapering. by Ryo Matsuda (685668)

“…See text for details.</p> <p>Scales bars: 50um. </p></div>…”

Data_Sheet_1_Biological Characterization of Hepatitis B virus Genotypes: Their Role in Viral Replication and Antigen Expression.docx by María Mercedes Elizalde (5184335)

“…By transfecting HuH-7 cells with unit-length constructs of genotypes A2, B2, C1, D1, and F1b, we identified major differences in HBV replicative capacity and antigen expression across genotypes. …”

Small Molecule R1498 as a Well-Tolerated and Orally Active Kinase Inhibitor for Hepatocellular Carcinoma and Gastric Cancer Treatment via Targeting Angiogenesis and Mitosis Pathway... by Chao Zhang (51048)

“…Lots of kinase inhibitors have entered into market and show promising clinical benefits. Here we report the discovery of a novel small molecule, well-tolerated, orally active kinase inhibitor, R1498, majorly targeting both angiogenic and mitotic pathways for the treatment of hepatocellular carcinoma (HCC) and gastric cancer (GC). …”

Anti-Cancer Effect of Thiacremonone through Down Regulation of Peroxiredoxin 6 by Miran Jo (533723)

“…Thiacremonone (0–50 μg/ml) inhibited lung cancer cell growth in a concentration dependent manner through induction of apoptotic cell death accompanied by induction of cleaved caspase-3, -8, -9, Bax, p21 and p53, but decrease of xIAP, cIAP and Bcl2 expression. …”

Data_Sheet_3_The burden of epilepsy in the People’s Republic of China from 1990 to 2019: epidemiological trends and comparison with the global burden of epilepsy.PDF by Yun Shu (2016445)

“…However, Disability-Adjusted Life Years (DALY) decreased notably, and the proportion of Years of Life Lost (YLL) decreased from 62.73 to 39.03%. …”

Table_1_School-Based Prevention Targeting Non-Suicidal Self-injury: A Pilot Study.docx by Imke Baetens (5195765)

“…Regarding secondary outcome measures, we also observed increased emotional awareness in both groups. …”

DataSheet1_The mechanisms of potassium loss in acute myocardial ischemia: New insights from computational simulations.docx by Jose M. Ferrero (6705797)

“…In order to investigate these mechanisms, we developed a novel computational model of acute myocardial ischemia which couples a) an electrophysiologically detailed human cardiomyocyte model that incorporates modifications to account for ischemia-induced changes in transmembrane currents, with b) a model of cardiac tissue and extracellular K⁺ transport. …”