Effects of 40 mg·kg⁻¹ wogonin on TLR4 expresssion. by Chien-Cheng Chen (207053)

“…Sections were stained with DAPI (blue) to show all nuclei. The scale bar is 50 µm. Values are reported as means ± SEM; *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 versus sham controls, and ^†<i>P</i><0.05 for wogonin-treated versus vehicle-treated TBI mice (n = 7 mice/group).…”

Model Input Parameters^*. by Lisa G. Suter (410040)

“…Standard implants had long-term failure rates as high as 5.44% in the sensitivity analysis exploring the impact of higher long-term failure in healthy 50–59-year-olds, producing a failure rate of 4.35% for an innovative implant offering a 20% decrease in long-term failure.…”

Metabolically healthy obesity and depressive symptoms: 16-year follow-up of the Gazel cohort study by Guy-Marino Hinnouho (3909874)

“…</p><p>Methods</p><p>A sample of 14 475 participants (75% men), aged 44–59 years in 1996, was drawn from the Gazel cohort. …”

Data_Sheet_1_Estimation of the economic impact of a bluetongue serotype 4 outbreak in Tunisia.docx by Ameni Ben Salem (18073126)

“…In cattle, exposure to BTV led to a daily unit milk yield decrease of 12.50 to 14.66 L over an average period of 5 months. …”

Supplementary Material for: Multimorbidity and readmissions in older people with acute coronary syndromes by Gudnadottir G.S. (11959496)

“…Aims: To examine the multimorbidity as well as the 30-day and one-year readmission rates, in a large, unselected cohort of elderly patients with acute coronary syndrome (ACS). …”

Data Sheet 1_The effect of Traditional Chinese Medicine on patients undergoing targeted therapy for primary liver cancer: a systematic review and meta-analysis.docx by Hongting Yan (13242201)

“…</p>Results<p>Targeted therapy for liver cancer patients who received TCM treatment showed improvements in objective response rate (ORR) (RR, 1.49 [1.33-1.66], P < 0.0001), disease control rate (DCR) (RR, 1.32 [1.25,1.40], P < 0.0001), the 1-year survival (RR, 1.50 [1.20,1.88]; P = 0.0004) and Karnofsky Performance Status (KPS) (SMD, 1.34 [0.86,1.81]; P < 0.0001), and can reduce the incidence of adverse events, as well as to some extent decrease the production of tumor markers and related inflammatory factors.…”

Nuclear Quantum Effects in Sodium Hydroxide Solutions from Neural Network Molecular Dynamics Simulations by Matti Hellström (1886893)

“…Moreover, NQEs significantly lower the proton transfer barriers, thus increasing the proton transfer rates, resulting in an increase of the diffusion coefficient in particular of OH^–, as well as a decrease of the mean residence time of molecules in the first hydration shell around Na⁺ at high NaOH concentrations.…”

Disease course of Chronic Relapsing Inflammatory Optic Neuropathy (CRION) in a single care center by Luis Enrique MOLINA-CARRIÓN (12687286)

“…Infections, autoimmune diseases, and multiple sclerosis, among other conditions, were ruled out in all patients. Results: We analyzed 30 patients with CRION: 24 women and six men, with mean age of 42.8±10.2 years, median disease course of 7.9 years (5.29-13.1), and median number of attacks of 2 (IQR 2-4). …”

Video1_One-year real-world experience with mavacamten and its physiologic effects on obstructive hypertrophic cardiomyopathy.mov by Daniel Seung Kim (19510291)

“…Moreover, in our center's experience, neither arrhythmia burden, nor contractility have worsened in the vast majority of patients: we note a clinically insignificant mean decrease in left ventricular ejection fraction (LVEF), with only two patients requiring temporary mavacamten discontinuance for LVEF < 50%. …”

Video1_One-year real-world experience with mavacamten and its physiologic effects on obstructive hypertrophic cardiomyopathy.mov by Daniel Seung Kim (19510291)

“…Moreover, in our center's experience, neither arrhythmia burden, nor contractility have worsened in the vast majority of patients: we note a clinically insignificant mean decrease in left ventricular ejection fraction (LVEF), with only two patients requiring temporary mavacamten discontinuance for LVEF < 50%. …”

Increased Autophagy in <i>daf-2/</i>insulin/IGF Receptor Mutants Is Independent of the <i>daf-16</i>/FOXO and <i>pha-4</i>/FOXA Transcription Factors by Malene Hansen (10367)

“…The mean lifespan of <i>daf-2(e1370)</i> animals was shortened 12.5% by <i>pha-4</i> RNAi ([<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0040024#pgen-0040024-b028" target="_blank">28</a>] and data not shown), and we measured an 11% decrease in puncta in <i>daf-2(e1370)</i> animals fed <i>pha-4</i> RNAi. …”

The association between observed mobility and quality of life in the near elderly by Jason Shafrin (4379500)

“…This cross-sectional study aimed to assess the association between mobility and quality of life measures in the near elderly.</p><p>Methods</p><p>A prospective observational study of persons aged 50–69 years was conducted. …”

The effect of stress on sound processing increases with repeated exposure. by Ghattas Bisharat (20706928)

“…We found a negative slope in most PPY and PV cells, indicating a decrease in activity as the stress becomes chronic (<i>t</i> test for PPY cells <i>p</i> = 9.8 × 10⁻¹⁴, PV cells <i>p</i> = 0.006) and a positive slope for SST cells indicating an increase in activity with successive applications of the stressor (<i>t</i> test for SST cells <i>p</i> = 9.5 × 10⁻⁰⁶). …”

Data_Sheet_1_The Association Between Changes in the University Educational Setting and Peer Relationships: Effects in Students' Depressive Symptoms During the COVID-19 Pandemic.PDF by Virgínia Conceição (10678363)

“…Depressive symptoms increased significantly from October 2019 to June 2020, and the mean scores grew until March 2021. Anxiety symptoms also significantly increased from October 2019 to June 2020; however, from June 2020 to March 2021, there was a non-significant decrease in the proportion. …”

Table_1_The safe lowest effective power of subthreshold micropulse laser treatment in Chinese patients with acute or chronic central serous chorioretinopathy.DOCX by Ting Xie (191025)

“…We found that the lowest effective laser power for acute CSC was 425 mW (−225.50 μm vs. −171.24 μm vs. −114.50 μm vs. −130.54 μm vs. −68.00 μm, p < 0.001), showing a significant CMT reduction at this power, but no significant increase in BCVA (−0.15 ± 0.10 logMAR vs. −0.20 ± 0.16 logMAR vs. −0.14 ± 0.11 logMAR vs. −0.17 ± 0.30 logMAR vs. −0.11 ± 0.14 logMAR, p > 0.05). …”

Red Blood Cell Transfusion and Mortality in Trauma Patients: Risk-Stratified Analysis of an Observational Study by Pablo Perel (102217)

“…Transfusion was associated with an increase in all-cause mortality among patients with &lt;6% and 6%–20% predicted risk of death (odds ratio [OR] 5.40, 95% CI 4.08–7.13, <i>p&lt;</i>0.0001, and OR 2.31, 95% CI 1.96–2.73, <i>p&lt;</i>0.0001, respectively), but with a decrease in all-cause mortality in patients with &gt;50% predicted risk of death (OR 0.59, 95% CI 0.47–0.74, <i>p&lt;</i>0.0001). …”

Sample details and genome coverage (n = 1,409). by Mathieu Vanhove (3298326)

Video_1_Robustness and Scalability of Regional Climate Projections Over Europe.mp4 by Dominic Matte (6270914)

“…Despite considerable model improvements as well as increasingly higher model resolutions in regional downscaling efforts, these apparent inconsistencies so far seem unresolved. In the present study, we analyze European seasonal temperature and precipitation climate change projections using all readily available pan-European regional climate model projections for the twenty-first century with model resolution increasing from ≈50 to ≈12 km grid distances from the CORDEX modeling project. …”

The effect of hydroxychloroquine on lupus erythematosus-like skin lesions in MRL/lpr mice by Tatsuya Shimomatsu (1545943)

“…The average number of mast cells was 81, 50, and 12 (magnification, ×100), the mortality rate was 24%, 8%, and 9% and the mean body weight gain was 4.6 g, 8.0 g and 5.1 g, respectively.…”

Video_2_Robustness and Scalability of Regional Climate Projections Over Europe.MP4 by Dominic Matte (6270914)

“…Despite considerable model improvements as well as increasingly higher model resolutions in regional downscaling efforts, these apparent inconsistencies so far seem unresolved. In the present study, we analyze European seasonal temperature and precipitation climate change projections using all readily available pan-European regional climate model projections for the twenty-first century with model resolution increasing from ≈50 to ≈12 km grid distances from the CORDEX modeling project. …”