Host population bottlenecks decrease microbiome diversity. حسب Michael Ørsted (5926028)

2‑Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2) حسب Ariel L. Burgio (15069256)

"…To develop more potent compounds, we initiated a structure–activity relationship study that identified 2-aminobenzoxazole as a viable scaffold. …"

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... حسب Shuhei Ikeda (2380180)

"…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC₅₀ 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…"

Mutations decreasing complexity are more frequent than mutations increasing it. حسب Pascal F. Hagolani (10189866)

E₅₀ values. حسب Junxia Zhou (14381598)

Estimated niche width for 11 native fish species in <i>Arapaima gigas</i> colonized and non-colonized lakes. حسب Danny Rejas (583637)

Data_Sheet_1_Microclimatic Warming Leads to a Decrease in Species and Growth Form Diversity: Insights From a Tropical Alpine Grassland.PDF حسب Sisimac A. Duchicela (11503918)

"…After 7 years of warming, we found significant increases in mean monthly (+0.24°C), daily (+0.16°C), and night air temperatures (+0.33°C) inside the OTCs, and the OTCs intensified microclimatic conditions during the dry season. …"

Proline is toxic in cells unable to catabolize it. حسب Fitz Gerald S. Silao (9384713)

Proline catabolism is required for invasive growth. حسب Fitz Gerald S. Silao (9384713)

Proline catabolism is required for virulence in <i>Drosophila</i> and murine infection models. حسب Fitz Gerald S. Silao (9384713)

Frequency of proestrus in non-tumor and tumor-bearing female mice. حسب Robert Botelho (20308297)

Emerging Disinfection Byproduct 2,6-Dichlorobenzoquinone-Induced Cardiovascular Developmental Toxicity of Embryonic Zebrafish and Larvae: Imaging and Transcriptome Analysis حسب Xue Yang (144876)

"…Aromatic DBPs represent a significant portion of total DBPs, but their effects on cardiovascular development are unclear. In this study, we examined the effects of an aromatic DBP, 2,6-dichlorobenzoquinone (DCBQ), on the cardiovascular development of zebrafish embryos. …"

I348T increases H77 entry dependency on SR-BI, while T385P decreases H77 entry dependency on SR-BI. حسب Christina Holmboe Olesen (11154333)

Effects of E-cad::EOS overexpression on E-cadherin levels. حسب Miguel Ramirez Moreno (11034894)

"…The paired-samples Wilcoxon test was used to compare expressing (E-cad, blue in B) and non-expressing areas in same wing discs (C, black in B). …"

The fraction of predicted heterozygotes that are set to “No Call” by RHA decreases as the size of the heterozygote cluster increases. حسب Orna Mizrahi-Man (42539)

DataSheet_1_Hemizygous nonsense variant in the moesin gene (MSN) leads to a new autoimmune phenotype of Immunodeficiency 50.pdf حسب András L. Kovács (13565251)

"…We present a putative new autoimmune phenotype of Immunodeficiency 50 (MIM300988) characterized by antiphospholipid syndrome, Hashimoto’s thyroiditis, leg ulcers, and juvenile tooth loss, associated with W217X mutation of the MSN gene.…"

Supplementary Figure 3 from Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFβ Signaling Pathway حسب Guillaume Desnoyers (232704)

The activity of LET-60ras is inhibited by oxidation of C118. حسب Maximilian Kramer-Drauberg (8981141)

Supplementary Figure 2 from Decreased eIF3e Expression Can Mediate Epithelial-to-Mesenchymal Transition through Activation of the TGFβ Signaling Pathway حسب Guillaume Desnoyers (232704)

"…<p>Supplementary Figure 2- Phosphorylation of eIF4E is decreased in A549 and MCF-10A cells that have decreased eIF3e expression. …"

Homologues of the <i>A</i>. <i>thaliana</i> gene AT3G59280 identified by BlastP search (E value < 1E-5). حسب Chloe Casey (14341756)