CDA deficiency leads to excess dCTP, inhibiting PARP-1 activity and leading to UFB formation. by Simon Gemble (168663)

“…(G) (1) CDA deficiency leads to intracellular dCTP accumulation, decreasing basal PARP-1 activity. (2) The decrease in basal PARP-1 activity leads to an increase in unreplicated DNA sequences (preferentially at centromeres and CFS sites). (3) During late G2/early mitosis, some of this unreplicated DNA is probably processed by MUS81-EME1 and ERCC1 nucleases as previously suggested [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref036" target="_blank">36</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref012" target="_blank">12</a>], leading to DNA synthesis during metaphase (EdU foci) and preventing supernumerary UFB formation. (4) Some of the excess unreplicated DNA sequences are not processed by the nucleases, leading to supernumerary UFB formation.…”

Beta power timecourses time-locked to the response (button press at time zero), expressed as percent change from baseline in the SMOT areas. by Lauren E. Beaton (4763232)

“…After the switch and immediately preceding the response (highlighted in dark blue color), the primed hemisphere rebounds back to baseline while the responding hemisphere continues to decrease. In the right panel, lateralized beta power is presented in the bar graphs as a subtraction of beta power in the contralateral—ipsilateral SMOT in the early (-300 to -200 ms) vs late (-100 to 0 ms) time windows.…”

Table 1_Trends in the disease burden of maternal sepsis and other maternal infections attributable to iron deficiency from 1990 to 2021 and its projection until 2050.docx by Chunfeng Zhu (327990)

“…The ASMR and age-standardized DALY rate of MSMIs attributable to iron deficiency were negatively correlated with SDI. Projections indicated a continued decrease in the burden of MSMIs attributable to iron deficiency by 2050.…”

Table 1_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.docx by Ana Virseda-Berdices (9638081)

“…</p>Results<p>Seven patients (14.5%) reduced LSM by over 50%. We found 47 significant differentially expressed (SDE) genes associated with reaching an LSMred>50% after achieving HCV eradication, 42 upregulated and 5 downregulated in the LSMred>50% group. …”

Data Sheet 1_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.docx by Ana Virseda-Berdices (9638081)

“…</p>Results<p>Seven patients (14.5%) reduced LSM by over 50%. We found 47 significant differentially expressed (SDE) genes associated with reaching an LSMred>50% after achieving HCV eradication, 42 upregulated and 5 downregulated in the LSMred>50% group. …”

Table 2_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.docx by Ana Virseda-Berdices (9638081)

“…</p>Results<p>Seven patients (14.5%) reduced LSM by over 50%. We found 47 significant differentially expressed (SDE) genes associated with reaching an LSMred>50% after achieving HCV eradication, 42 upregulated and 5 downregulated in the LSMred>50% group. …”

Table 4_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.docx by Ana Virseda-Berdices (9638081)

“…</p>Results<p>Seven patients (14.5%) reduced LSM by over 50%. We found 47 significant differentially expressed (SDE) genes associated with reaching an LSMred>50% after achieving HCV eradication, 42 upregulated and 5 downregulated in the LSMred>50% group. …”

Table 3_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.docx by Ana Virseda-Berdices (9638081)

“…</p>Results<p>Seven patients (14.5%) reduced LSM by over 50%. We found 47 significant differentially expressed (SDE) genes associated with reaching an LSMred>50% after achieving HCV eradication, 42 upregulated and 5 downregulated in the LSMred>50% group. …”

Image 1_PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.pdf by Ana Virseda-Berdices (9638081)

“…</p>Results<p>Seven patients (14.5%) reduced LSM by over 50%. We found 47 significant differentially expressed (SDE) genes associated with reaching an LSMred>50% after achieving HCV eradication, 42 upregulated and 5 downregulated in the LSMred>50% group. …”

Evidence for constitutive activation of cytoprotective enzymes network in vitiligo melanocyte cultures. by Barbara Bellei (177809)

“…Values reported as O.D. decrease over untreated control represent the means ± SD of experiments performed in triplicate. …”

Lack of oligodendrocytes after DTA-mediated ablation of <i>C1ql1</i>-expressing OPCs. by Shayan Moghimyfiroozabad (19066182)

“…Higher magnification of the coronal sections in the center and lateral parts of CC and cortex shows the dramatic reduction in the density of OLs (CC1^pos GFP^pos cells, yellow arrowhead) in <i>C1ql1</i>^<i>Cre</i><i>; Sox10</i>^<i>DTA</i> mice at P16. Scale bars = 100 μm. Quantification shows a massive decrease in OL density in the <i>C1ql1</i>^<i>pos</i> OPC-ablated brains. …”

Relative activities of oxidizing enzymes in activated sludge during the stable stage. by Cong Jiang (3175146)

“…The relative activity is less 100% indicating a decrease of enzyme activity (compared to the control). asterisks (*) indicating the statistical difference from the control (<i>p</i> < 0.05).…”

Effect of pulse electrical field on tumor absolute impedance. by Yossi Mandel (289945)

“…Impedance was measured at frequencies of 100 Hz–100 kHz. Pulsed electrical field caused a 4-fold decrease in absolute tumor impedance and loss of frequency relaxation, suggestive of membrane breakdown. …”

DAI score. by Nihal Hasan (15453216)

Data_Sheet_1_Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes.pdf by Raj Kumar Sah (8521731)

“…We found that 10–42 h post invasion (hpi), SphK1 level was predominantly reduced to ∼50% in rings, trophozoites, and schizonts compared to uninfected erythrocytes. …”

Supplementary figure.1.tif by liang lv (5903513)

“…*p<0.05, **p< 0.01, scale bar, 200μm (a,b), <a></a><a>50μm (c)</a>, 100μm (d,g).</p>…”

Capillary Filling of Polymer Chains in Nanopores by Jianwei Zhang (13799)

Table_1_Estimating Factors Related to Fluoroquinolone Resistance Based on One Health Perspective: Static and Dynamic Panel Data Analyses From Europe.doc by Dandan Zhang (228849)

“…The 10% increase in veterinary AMC was related to a 1.65% decrease of P. aeruginosa resistance rates to fluoroquinolones (Coef. = −0.165, p = 0.019).…”

File S1 - Impaired Functionality of Antiviral T Cells in G-CSF Mobilized Stem Cell Donors: Implications for the Selection of CTL Donor by Carola E. Bunse (492512)

“…Functional assays for </b><b><i>in vitro</i></b><b> G-CSF-treated pCMV_pp65_A02-stimulated cells on day 7.</b> (A) IFN-γ ELISpot reveals a decrease in IFN-γ secretion after G-CSF treatment. …”

Inhibition of mitochondrial oxidation prevents adipogenic differentiation of hMSCs. by Yanmin Zhang (391964)

“…<p><b>A)</b> 100 nM rotenone decreased the baseline oxygen consumption rate (OCR) and maximal respiration capacity (induced by FCCP treatment) in hMSCs (n = 7 for each group). …”