Table 1_Sediment exposure decreases diversity in the surface mucus layer microbiome of Porites lobata at Honoliʻi, Hawaiʻi.xlsx by Joseph W. P. Nakoa (21796214)

The expression of <i>Zif268</i> is decreased in the dentate gyrus of HIWM trained rats as compared to RM or LIWM rats. by Mickaël Antoine Joseph (821433)

Improvement of the eye morphology and the motor performance phenotypes of FRDA flies by decreased expression of genes implicated in zinc and copper homeostasis. by Sirena Soriano (348274)

Inhibition of MMP2 decreases apoptosis and attenuates insulin secretion dysfunction caused by oxidative stress in INS-1 cells. by Chongxiao Liu (644813)

Selection for rare alleles that increase the rate of (a) monandry or (b) selfing. by Michael Francis Scott (5447600)

IMB5043 arrests G₂/M phase and decreases the motility and invasion of SMMC-7721 cells. by Jianhua Gong (530290)

“…<p>(A). Cell cycle distribution was determined by flow cytometry after PI staining. …”

Integration of Metabolomics, Transcriptomics, and 16s rRNA Sequencing Reveals the Mechanism of Morus alba <i>L.</i> (Sangzhi) Alkaloids (SZ-A) in Improving Cholesterol Metabolism i... by Caina Li (4126462)

“…SZ-A also significantly lowered the expression of aldo-keto reductase 1b7 and its upstream gene farnesoid X receptor (FXR) and increased the expression of cholesterol 7α-hydroxylase and small heterodimer partner. …”

Fig 1 - by Pedro A. R. Vanzele (17655589)

S1 Fig - by Pedro A. R. Vanzele (17655589)

Fig 4 - by Pedro A. R. Vanzele (17655589)

Numbers of supporting cells are unaffected in morphants, while numbers of hair cells decrease in morphants. by Fei Liu (21082)

siRNA-based knockdown of <i>CLU</i> results in decreased VWF and CLU protein expression but no change in <i>VWF</i> mRNA content. by Allaura A. Cox (17980027)

Targeting of Vps34 reduces B16F10 tumor growth and working model for Vps34-dependent regulation of eTreg transitional heterogeneity and maintenance. by Erienne G. Norton (9612079)

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Experimental design depicting ampicillin treatment of <i>B</i>. <i>germanica</i>. by Seogwon Lee (11747633)

Image_1_TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke.TIF by Pin-yi Liu (7136123)

“…Furthermore, our mechanistic study showed that TMEM16A knockdown alleviated NF-κB activation and nuclear translocation, indicating that TMEM16A knockdown downregulated OGD/R-induced ICAM-1 expression in an NF-κB-dependent manner. …”

Image_2_TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke.TIF by Pin-yi Liu (7136123)

“…Furthermore, our mechanistic study showed that TMEM16A knockdown alleviated NF-κB activation and nuclear translocation, indicating that TMEM16A knockdown downregulated OGD/R-induced ICAM-1 expression in an NF-κB-dependent manner. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Most of the designed derivatives were active at micromolar or submicromolar concentration, and the most promising compounds are fluorinated and/or amino acids derivatives <b>13a</b>, <b>14d</b>, and <b>15</b> that showed IC₅₀ 0.16–0.82 μM. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Most of the designed derivatives were active at micromolar or submicromolar concentration, and the most promising compounds are fluorinated and/or amino acids derivatives <b>13a</b>, <b>14d</b>, and <b>15</b> that showed IC₅₀ 0.16–0.82 μM. …”