Supplementary Material for: Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes by Chen T.K. (14350107)

“…Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined associations of five urinary biomarkers of tubular injury and repair (NGAL, KIM-1, IL-18, MCP-1, YKL-40) with kidney function decline (first occurrence of a decrease in eGFR≥30 ml/min/1.73 m2 if randomization eGFR≥60 or ≥50% if randomization eGFR<60; ESKD) and all-cause mortality among 1,135 VA NEPHRON-D trial participants with baseline UACR ≥300 mg/g and available urine samples. …”

QTL for reduced MA sensitivity (D2 < B6) in B6 x D2-F₂ mice. by Neema Yazdani (835533)

“…To further dissect the time dependency of this locus, we generated LOD scores from the same mice in six, 5-min time bins over 30 min. …”

EWS downregulation affects apoptosis, cell cycle and proliferation. by Sujitha Duggimpudi (699551)

“…<p><b>A</b>. Decrease in the relative mRNA levels of FBXW7 upon knocking down EWS. …”

TPA-induced Mcl-1 stabilization is associated with increased resistance to various chemotherapeutic agents in BL41-3 cells. by Shanna K. Nifoussi (128297)

“…<p><b>A:</b> BL41-3 cells were incubated in the absence or presence of TPA (5 nM) for 0.5 hours, followed by the addition of the indicated concentrations of etoposide. …”

Table2_Real-World Effectiveness of Inhalation Therapy Among Patients With Symptomatic COPD in China: A Multicenter Prospective Study.docx by Wei Cheng (52808)

“…</p><p>Results: In 695 patients, the mean age was 62.5 ± 8.2 years, with a mean CAT score of 15.1 ± 6.0. …”

Table1_Real-World Effectiveness of Inhalation Therapy Among Patients With Symptomatic COPD in China: A Multicenter Prospective Study.docx by Wei Cheng (52808)

“…</p><p>Results: In 695 patients, the mean age was 62.5 ± 8.2 years, with a mean CAT score of 15.1 ± 6.0. …”

Table3_Real-World Effectiveness of Inhalation Therapy Among Patients With Symptomatic COPD in China: A Multicenter Prospective Study.docx by Wei Cheng (52808)

“…</p><p>Results: In 695 patients, the mean age was 62.5 ± 8.2 years, with a mean CAT score of 15.1 ± 6.0. …”

SOX4 trans-activates the transcription of <i>SEMA3</i>, <i>Plexin</i>, and <i>NRP1</i>. by Hsin-Yi Huang (111181)

“…Error bars, SD, n = 5. Student's <i>t</i>-test, *, <i>P</i><0.01; **, <i>P</i><0.001. …”

Image_1_Sphingosine-1-Phosphate and Its Signal Modulators Alleviate Psoriasis-Like Dermatitis: Preclinical and Clinical Evidence and Possible Mechanisms.tif by Liu Liu (512237)

“…The pooled results showed that compared with control treatment, S1P receptor agonists [mean difference (MD): −6.80; 95% confidence interval (CI): −8.23 to −5.38; p<0.00001], and sphingosine kinase 2 inhibitors (MD: −0.95; 95% CI: −1.26 to −0.65; p<0.00001) alleviated psoriasis-like dermatitis in mice. …”

Image_10_Sphingosine-1-Phosphate and Its Signal Modulators Alleviate Psoriasis-Like Dermatitis: Preclinical and Clinical Evidence and Possible Mechanisms.tif by Liu Liu (512237)

“…The pooled results showed that compared with control treatment, S1P receptor agonists [mean difference (MD): −6.80; 95% confidence interval (CI): −8.23 to −5.38; p<0.00001], and sphingosine kinase 2 inhibitors (MD: −0.95; 95% CI: −1.26 to −0.65; p<0.00001) alleviated psoriasis-like dermatitis in mice. …”

Video_1_The interpositional bypass with a parietal branch of superficial temporal artery graft for symptomatic atherosclerotic anterior cerebral artery stenosis or occlusion.MP4 by Chuyang Tai (18312727)

“…The ratio of ipsilateral/contralateral mean transit time in the superior frontal gyrus was decreased significantly after bypass (1.08 ± 0.07 vs. 1.23 ± 0.05, p < 0.001) and continued to decrease 6 months after surgery (1.05 ± 0.04 vs. 1.08 ± 0.07, p = 0.002). …”

High-Throughput Absolute mRNA Quantification Using Real-time RT-PCR by Anthony J Bais (13285305)

“…Fluorescence data was acquired at 510 nm during the 72 C extension phase. Melt curve analyses were performed with an initial 99-50 C cycling followed by fluorescence monitoring during heating at 0.2 C/second to 99 C. …”

Hfq melts the stem structure of but does not promote annealing by Véronique Arluison (25027)

“…Addition of Hfq results in gradual FRET decrease (average lifetime ∼15 min). () Average melting times were measured as a function of Hfq concentration (as plotted) and it decreases to ∼4 min in saturating concentrations of Hfq. () Hfq does not promote annealing of I and II. () Emission spectra of the mixture of 25 nM Cy3-I and 62.5 nM Cy5.5-II in T50 buffer without (black lines), after incubating the sample for 5 min without Hfq, and then with 28 nM of Hfq (blue lines).…”

Table_2_The Impact of the COVID-19 Pandemic on Women’s Reproductive Health.docx by Niamh Phelan (10450682)

“…There was no change in the median cycle length (28 days) or days of bleeding (5) but there was a wider variability of cycle length (p = 0.01) and a 1 day median decrease in the minimum (p < 0.0001) and maximum (p = 0.009) cycle length. …”

Table_1_The Impact of the COVID-19 Pandemic on Women’s Reproductive Health.docx by Niamh Phelan (10450682)

“…There was no change in the median cycle length (28 days) or days of bleeding (5) but there was a wider variability of cycle length (p = 0.01) and a 1 day median decrease in the minimum (p < 0.0001) and maximum (p = 0.009) cycle length. …”

Measurement of intracellular Ca²⁺, [Ca²⁺]_i, levels showing strong cross-talk between TRPV4 and the KCa channels in mCCDcl1. by Yue Li (102191)

“…Addition of the 4 Blockers had not affect in the absence of GSK101 (-), averaging 0.4 ± 2.5 nM (n = 24). In the presence of GSK101 (+), the 4 Blockers induce a marked decrease in [Ca²⁺]_i of 477 ± 45 nM (n = 24, P<0.001) with the 4 Blockers, demonstrates a strong functional cross-talk between TRPV4, [Ca²⁺]_I, and KCa channels. …”

Table1_Older postmenopausal women with lower lean mass have hypermethylated sites in the PI3K-Akt pathway.xlsx by Igor Massari Correia (15201868)

“…The participants' DNA was extracted using the Salting Out technique and subsequently, the Illumina 850k EPIC Infinium Methylation BeadChip was performed to obtain methylation data.</p><p>Results: We obtained 1,913 differentially methylated sites (p ≤ 0.005 of β > 5% and β < −5%) in a total of 979 genes between groups (p ≤ 0.005; −5% > β > 5%). …”

Table1_Older postmenopausal women with lower lean mass have hypermethylated sites in the PI3K-Akt pathway.xlsx by Igor Massari Correia (15201868)

“…The participants' DNA was extracted using the Salting Out technique and subsequently, the Illumina 850k EPIC Infinium Methylation BeadChip was performed to obtain methylation data.</p><p>Results: We obtained 1,913 differentially methylated sites (p ≤ 0.005 of β > 5% and β < −5%) in a total of 979 genes between groups (p ≤ 0.005; −5% > β > 5%). …”

Multiple pathways of alveolar macrophage death contribute to pulmonary inflammation induced by silica nanoparticles by Eun-Jung Park (201821)

“…<p>In our previous study, 20 nm-sized amorphous silica nanoparticles (20-SiNPs), but not 50 nm-sized amorphous silica nanoparticles (50-SiNPs), induced pulmonary inflammatory response in rats exposed repeatedly for 14 days (12.5, 25, and 50 μg/time, total six times). …”

Fluorescence quench titration of HSA with increasing PS concentrations. by Shevin R. Feroz (468333)

“…<p>[HSA] = 3 µM, [PS] = 0–22.5 µM with 1.5 µM intervals (1–16), λ_ex = 280 nm studied in 10 mM Tris-HCl buffer, pH 7.4, 25°C. …”