Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…Concomitant inhibition of key epigenetic pathways involved in silencing tumor suppressor genes has been recognized as a promising strategy for cancer therapy. Herein, we report a first-in-class series of quinoline-based analogues that simultaneously inhibit histone deacetylases (from a low nanomolar range) and DNA methyltransferase-1 (from a mid-nanomolar range, IC₅₀ < 200 nM). …”

Numeric representation of WLGS data. by Bernd Johannes (780947)

Bidirectional change in delta dipole density (DDD) after therapy by Marcus Meinzer (4548)

Tak et al models and scripts R1 by Peter Zeidman (11189391)

Measurement of oxidative stress in IEC. by Kamal Datta (310119)

Image_1_Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway.JPEG by Leigh Dairaghi (5591222)

“…Chronic treatment of nasal explants with CR-50, an antibody known to interfere with Reelin homopolymerization and Dab1 phosphorylation, decreased the distance GnRH neurons and OECs migrated. …”

Image_2_Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway.TIF by Leigh Dairaghi (5591222)

“…Chronic treatment of nasal explants with CR-50, an antibody known to interfere with Reelin homopolymerization and Dab1 phosphorylation, decreased the distance GnRH neurons and OECs migrated. …”

Table_1_Contemporary Chinese dietary pattern: Where are the hidden risks?.DOCX by Hong Xiang (739659)

DataSheet_1_Consequences of intra-canopy and top LED lighting for uniformity of light distribution in a tomato crop.docx by R. Schipper (14456997)

“…The variation was minimal when the ratio of PPFD from intra-canopy to top lighting was about 1, and increased when this ratio increased or decreased. Intra-canopy lighting resulted in 8% higher total light absorption than top lighting, while combining 50% intra-canopy lighting with 50% top lighting, increased light absorption by 4%. …”

Data Sheet 1_Primary care and specialist physicians’ prescribing preferences for concurrent probiotic-antibiotic therapy: a multinational clinical practice survey across 13 countri... by Stephan R. Vavricka (8994197)

“…Regional variations showed Lithuania, Colombia and Peru had the highest co-prescription rates (50% of physicians prescribing to >50% of patients), while Finland demonstrated more conservative patterns (50% prescribing to <25% of patients). …”

Supplementary Material.docx by Fabrice Roda (17861195)

Epistasis does not evolve in the simple LP model. by Jon F. Wilkins (527368)

“…The nature of epistasis between a mutation that increases one input value and a mutation that decreases the other will depend on the precise values of <i>x</i> and <i>y</i>. …”

Spatiotemporal distributions. by Yi Bai (450166)

Data type, resolution, and source. by Yi Bai (450166)

Video_3_Deep learning-based control framework for dynamic contact processes in humanoid grasping.MP4 by Shaowen Cheng (5767598)

Germination and initial development of Brachiaria brizantha and Brachiaria decumbens on exposure to cadmium, lead and copper by Karine Sousa Carsten Borges (6119447)

Response times. by Luke E. Hallum (10428478)

“…The leftmost gray box (labelled “0%”) encompasses four points showing mean response times for transitions from source luminance = 0% to destination luminances = 25, 50, 75, and 100% (x axis). These rise times (upward triangles) decreased with increasing destination luminance. …”

Methodology flow chart. by Yi Bai (450166)

Photomicrographs of representative immunostained sections of lung. by Yunlong Wang (180471)

<i>P</i> values for several categories of land usage. by Yi Bai (450166)