Copper detoxification contributes to <i>S</i>. <i>aureus</i> pathogenesis. by Javiera Norambuena (137228)

Table_1_Assessing brain microstructural changes in chronic kidney disease: a diffusion imaging study using multiple models.XLSX by Limei Han (395754)

“…</p>Results<p>Significant differences were noted in DTI, NODDI, and MAP-MRI parameters between CKD patients and controls (p < 0.05). DTI indicated a decrease in Fractional Anisotropy(FA) and an increase in Mean and Radial Diffusivity (MD and RD) in CKD patients. …”

Regression analysis of presence of pandemic and examination results. by Masahiko Ayaki (4621612)

A. mCSM-PPI2 predicted ΔΔG is linearly correlated with SPR determined ACE2 variant Spike RBD affinities for ACE2 variants with negative predicted ΔΔG. by Stuart A. MacGowan (11326845)

Mean quality of life (EQoL) score by days since intake, grouped by intake tertiles (from lowest to highest quality of life) routine service clinical intervention dataset 2014 to 20... by Theresa Caruana (15628074)

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) by F. Anthony Romero (2452198)

“…Structure–activity relationship studies coupled with further structure-based design targeting the LPF shelf, BC loop, and KAc regions allowed us to significantly increase potency and selectivity, resulting in the identification of non-CNS penetrant <b>19</b> (GNE-781, TR-FRET IC₅₀ = 0.94 nM, BRET IC₅₀ = 6.2 nM; BRD4(1) IC₅₀ = 5100 nΜ) that maintained good in vivo PK properties in multiple species. …”

FigShare_Data HbO2 JoP 50 (KMG).xlsx by Kayla Garvey (22027559)

“…High-altitude mice generally had greater aerobic capacity in hypoxia, in association with higher arterial O₂ saturation and lower P₅₀ (O₂ pressure at 50% Hb saturation) in most conditions. …”

A savanna response to precipitation intensity by Ryan S. Berry (3913207)

Robust Operation of Mesoporous Antireflective Coatings under Variable Ambient Conditions by Barry Reid (1559488)

“…For high-surface-energy materials, pores on the 2–50 nm (i.e., on the subwavelength scale) are subject to capillary condensation by surrounding gas phase water molecules, which hampers their functioning. …”

The OSC. by Alok Kumar Maity (2212204)

Detailed prevalence data from gnomAD [24] for ACE2 variants reported in Table 1. by Stuart A. MacGowan (11326845)

The structure of ACE2 (green) gnomAD [24] missense variant p.Lys26Arg that enhances Spike (light blue) binding affinity. by Stuart A. MacGowan (11326845)

Structural description of the ACE2 –Spike-protein interface. by Stuart A. MacGowan (11326845)

mCSM-PPI2 predicted ΔΔG with and without recalibration are in agreement with published deep mutagenesis binding data [22] at low predicted ΔΔG but recalibrated predictions are more... by Stuart A. MacGowan (11326845)

Estimated allele frequencies of potential novel variants in ACE2 with predicted Spike binding phenotypes. by Stuart A. MacGowan (11326845)

mCSM-PPI2 predictions for all gnomAD ACE2 missense variants in residues resolved in PDB 6vw1. by Stuart A. MacGowan (11326845)

Distribution of mCSM-PPI2 [13] predicted ΔΔG from in silico saturation mutagenesis of the ACE2-S interface in PDB 6vw1 [11]. by Stuart A. MacGowan (11326845)

Surface plasmon resonance derived ΔΔG and mCSM-PPI2 [13] predictions for ACE2 mutants, including gnomAD [24] missense variants, at or near the ACE2 Spike interface. by Stuart A. MacGowan (11326845)

The relationship between experimental and predicted ΔΔG of ACE2 mutants and relative SARS-CoV-2 pseudotype infectivity reported by Shukla et al [38]. by Stuart A. MacGowan (11326845)

The structure of ACE2 (green) gnomAD [24] missense variant p.Ser19Pro that enhances Spike (light blue) binding affinity. by Stuart A. MacGowan (11326845)