Targeting hTERT Promoter G‑Quadruplex DNA Structures with Small-Molecule Ligand to Downregulate hTERT Expression for Triple-Negative Breast Cancer Therapy by Wei Long (411482)

“…Ligand <b>5</b> showed high affinity toward hTERT G4 (<i>K</i>_d = 1.1 μM) and potent activity against triple-negative breast cancer cells (MDA-MB-231, IC₅₀ = 1 μM). …”

Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks by Sofia Benfeito (4345591)

“…As opposed to <b>Mito.TPP</b>, these novel compounds were not cytotoxic to SH-SY5Y and HepG2 cells up to 50 μM and after 24 h of incubation. All of the cationic derivatives accumulated inside the mitochondrial matrix and acted as neuroprotective agents against iron(III), hydrogen peroxide, and <i>tert</i>-butyl hydroperoxide insults. …”

Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

“…Twenty-two compounds were found to inhibit HCV with EC₅₀ values ranging between 0.64 and 63 μM with compound <b>22</b> being the most active. …”

Synthesis, Biological Evaluation, Structure–Activity Relationship, and Mechanism of Action Studies of Quinoline–Metronidazole Derivatives Against Experimental Visceral Leishmaniasi... by Akanksha Upadhyay (6732857)

“…Among all synthesized derivatives, <b>15b</b> and <b>15i</b> showed significant antileishmanial efficacy against both extracellular promastigote (IC₅₀ 9.54 and 5.42 μM, respectively) and intracellular amastigote (IC₅₀ 9.81 and 3.75 μM, respectively) forms of Leishmania donovani with negligible cytotoxicity toward the host (J774 macrophages, Vero cells). …”

Detoxifying enzyme activities of slug larvae and adults treated with LC₅₀ for 24 and 48 h, respectively. by Haojun Li (11007721)

Protective enzyme activities of slug larvae and adults treated with LC₅₀ for 24 and 48 h, respectively. by Haojun Li (11007721)

Fig 1 - by Dalia Zaafar (6693017)

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Photomicrographs representing Bcl-2 immunoreactivity in the sarcoplasm of cardiomyocytes of mice of different groups. by Dalia Zaafar (6693017)

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Fig 4 - by Dalia Zaafar (6693017)

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Fig 5 - by Dalia Zaafar (6693017)

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Photomicrographs representing caspase-3 immunoreactivity in the sarcoplasm of cardiomyocytes of mice of different groups. by Dalia Zaafar (6693017)

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Fig 3 - by Dalia Zaafar (6693017)

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Contains all data used in the study. by Dalia Zaafar (6693017)

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Effect of sorafenib alone or added to hesperetin on the expression of NLRP3 inflammasome and TLR4 via western blotting in different groups. by Dalia Zaafar (6693017)

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One-way sensitivity analysis, <i>Immediate ART</i> strategy compared to <i>ART<350/μL</i>. by Eric N. Ouattara (6890174)

Discovery and Pharmacological Studies of 4‑Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis by José Ignacio Manzano (7908449)

“…We report the discovery of new 4-hydroxyphenyl phosphonium salt derivatives active in the submicromolar range (EC₅₀ from 0.04 to 0.28 μM, SI > 10) against the protozoan parasite Leishmania donovani. …”

Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients - Fig 3 by Tomoyoshi Komiyama (474366)

“…B: Isoproterenol was decreased by 5 mM for each 1/10 at the following concentrations: 5 nM, 50 nM, 500 nM, 5 μM, 50 μM, 500 μM, and 5 mM. …”

Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells by Yang Li (7082)

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Zwitterion-Functionalized Cuprous Oxide Nanoparticles for Highly Specific and Enzymeless Electrochemical Creatinine Biosensing in Human Serum by R. K. Rakesh Kumar (14241205)

“…A linear response to creatinine concentration from 10 to 200 μM (<i>R</i>² = 0.9876 and LOD = 5.0 μM) was observed, which covers the entire range of physiological creatinine in human serum. …”

Developmental toxicity induced by 2 μg/ml propofol. by Yali Ge (417371)