Morphological alterations on <i>S</i>. <i>aurantiacum</i> biofilm by scanning electron microscopy. by Rodrigo Rollin-Pinheiro (239450)

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Pandemic Response Box library screening data. by Rodrigo Rollin-Pinheiro (239450)

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Biofilm formation. by Rodrigo Rollin-Pinheiro (239450)

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LD- and haplotype-based measures of epistasis identify a narrow time window of epistasis detectability. by Gabriele Pedruzzi (5753792)

In Vitro Screening for ToxCast Chemicals Binding to Thyroxine-Binding Globulin by Stephanie A. Eytcheson (4284421)

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Antimicrobial activity of RP-1 peptide conjugate with ferrocene group by Natalia C. S. Costa (8626206)

“…The Fc-RP1 presented anti-amastigote activity against <i>Leishmania amazonensis</i> (IC₅₀ = 0.25 μmol L^–1). In comparison with amphotericin B, a second-line drug approved for leishmaniasis treatment, (IC₅₀ = 0.63 μmol L^-1), Fc-RP1 was more active and showed a 2.5-fold higher selectivity index. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Three compounds were selected, based on their activity against the intracellular amastigotes (EC₅₀ < 1 μM, SI > 10) and cruzain (IC₅₀ < 100 nM, SI > 5.55) which compared favorably with the approved drug, Benznidazole, and the well-established cruzain inhibitor K777. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Three compounds were selected, based on their activity against the intracellular amastigotes (EC₅₀ < 1 μM, SI > 10) and cruzain (IC₅₀ < 100 nM, SI > 5.55) which compared favorably with the approved drug, Benznidazole, and the well-established cruzain inhibitor K777. …”

Potent 5‑Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction by Wenjuan Zhou (115285)

“…After finding a novel inhibitor <b>DC-1</b> with IC₅₀ = 1.2 μM, we performed a series of chemical optimizations, which finally led to the discovery of a potent thiazole containing 5-cyano-6-phenylpyrimidin-based inhibitor <b>DC-2</b> (IC₅₀ = 15 nM). …”

DataSheet_2_A cyclic peptide-based PROTAC induces intracellular degradation of palmitoyltransferase and potently decreases PD-L1 expression in human cervical cancer cells.docx by Yu-Ying Shi (15975992)

“…Introduction<p>Our previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to a significant decrease in PD-L1 expression in tumors. However, this degradation is not a sustained and efficient process. …”

DataSheet_1_A cyclic peptide-based PROTAC induces intracellular degradation of palmitoyltransferase and potently decreases PD-L1 expression in human cervical cancer cells.docx by Yu-Ying Shi (15975992)

“…Introduction<p>Our previous research has found that degradation of palmitoyltransferase in tumor cells using a linear peptide PROTAC leads to a significant decrease in PD-L1 expression in tumors. However, this degradation is not a sustained and efficient process. …”

Identification of druggable small molecule antagonists of the <i>Plasmodium falciparum</i> hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway... by Monique R. Heitmeier (6686069)

“…WU-1 showed comparable potency in blocking 2-DG uptake in freed parasites and inhibiting parasite growth, with an IC₅₀ of 6.1 ± 0.8 μM and EC₅₀ of 5.5 ± 0.6 μM, respectively. …”

Cell invasiveness in metastatic cancer cells exposed to their IC₅₀ Aur for 24 h. by Sara Rodríguez-Enríquez (4373332)

Migratory capacity in metastatic cancer cells exposed to IC₅₀ Aur for 24 h. by Sara Rodríguez-Enríquez (4373332)

Nitrogen nutrition is a key modulator of the sugar and organic acid content in citrus fruit by Ling Liao (385468)

“…Sucrose and ascorbic acid content increased (8.46 to 50.97 mg g^-1 and 8.16 to 27.39 mg g^-1, respectively), while citric acid content decreased (90.81 to 0.02 mg g^-1). …”

Respiratory pattern. by Yoichiro Kitajima (4319455)

Protocols. by Yoichiro Kitajima (4319455)

Results of drought treatments comparison within Mg levels and soybean genotypes. by Amanda Soares Santos (16962244)

Ectopic development of a small number of adipocytes, as well as mitochondrial morphology and dynamics, in thymus from cocaine-administered rats. by Kana Unuma (283272)

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Apoptosis in thymus from cocaine-administered rats. by Kana Unuma (283272)

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