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Showing 61 - 80 results of 8,883 for search '(( 50 μ decrease ) OR ( 50 ((((we decrease) OR (026 decrease))) OR (nn decrease)) ))', query time: 0.53s Refine Results
  1. 61
    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer

    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

    Published 2021
    “…As a vital kinase in the glycolysis system, PKM2 is extensively expressed in colorectal cancer (CRC) to support the energy and biosynthetic needs. In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC<sub>50</sub> = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC<sub>50</sub> = 0.66 μM) and SW480 (IC<sub>50</sub> = 0.22 μM) cells. …”
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  2. 62
    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer

    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

    Published 2021
    “…As a vital kinase in the glycolysis system, PKM2 is extensively expressed in colorectal cancer (CRC) to support the energy and biosynthetic needs. In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC<sub>50</sub> = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC<sub>50</sub> = 0.66 μM) and SW480 (IC<sub>50</sub> = 0.22 μM) cells. …”
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  3. 63
    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer

    Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

    Published 2021
    “…As a vital kinase in the glycolysis system, PKM2 is extensively expressed in colorectal cancer (CRC) to support the energy and biosynthetic needs. In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC<sub>50</sub> = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC<sub>50</sub> = 0.66 μM) and SW480 (IC<sub>50</sub> = 0.22 μM) cells. …”
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  4. 64
    Temporal profiles of the key BO-NN features.

    Temporal profiles of the key BO-NN features. by Julia Berezutskaya (9080269)

    Published 2020
    “…Right plot show the gradual decrease in the TM tuning for the features highlighted in <b>c</b> as well as the gradual increase in the temporal response profile (i.e. optimal shifts for the prediction of the key BO-NN features using Praat features shown in <b>a</b>). …”
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  5. 65
    The inhibitory activity of the most active compounds against Glo-I enzyme with less than 50 µM. Their supportive corresponding docking values on two different protocols are displayed.

    The inhibitory activity of the most active compounds against Glo-I enzyme with less than 50 µM. Their supportive corresponding docking values on two different protocols are display... by MohammedBashar Al-Qazzan (22439236)

    Published 2025
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  6. 66
    Trace-weighted images at b = 50 s/mm<sup>2</sup>.

    Trace-weighted images at b = 50 s/mm<sup>2</sup>. by Tobit Führes (12647099)

    Published 2023
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  7. 67
    Repeated LSPC treatment prolongs survival of and decreases PrP<sup>Res</sup> accumulation in a subset of prion-infected mice.

    Repeated LSPC treatment prolongs survival of and decreases PrP<sup>Res</sup> accumulation in a subset of prion-infected mice. by Heather Bender (363996)

    Published 2019
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  8. 68
    DataSheet1_Solamargine Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma by Decreasing LncRNA HOXA11-As Expression.PDF

    DataSheet1_Solamargine Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma by Decreasing LncRNA HOXA11-As Expression.PDF by Ying Meng (327793)

    Published 2022
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  9. 69
    Prorocentin-5: A Cytotoxic Polyketide from the Benthic Marine Dinoflagellate <i>Prorocentrum lima</i>

    Prorocentin-5: A Cytotoxic Polyketide from the Benthic Marine Dinoflagellate <i>Prorocentrum lima</i> by Yunseok Choi (5625245)

    Published 2024
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  10. 70
    Shows the 5′ region and the exons of the <i>C3</i> gene in the vertical line and the three new SNPs that we found by sequencing.

    Shows the 5′ region and the exons of the <i>C3</i> gene in the vertical line and the three new SNPs that we found by sequencing. by Yonghui Wang (287491)

    Published 2022
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  11. 71
    DataSheet_1_A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.pdf

    DataSheet_1_A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.pdf by Chun-Hsien Wu (449156)

    Published 2020
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  12. 72
    DataSheet_1_A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.pdf

    DataSheet_1_A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.pdf by Chun-Hsien Wu (449156)

    Published 2021
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  13. 73
    <b>Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decrease ISR activation in DRG neurons</b>

    <b>Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decrease ISR activation in DRG neurons</b> by Muhammad Saad Yousuf (20745168)

    Published 2025
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  14. 74
    Extracellular vesicles isolated from patients undergoing remote ischemic preconditioning decrease hypoxia-evoked apoptosis of cardiomyoblasts after isoflurane but not propofol exposure

    Extracellular vesicles isolated from patients undergoing remote ischemic preconditioning decrease hypoxia-evoked apoptosis of cardiomyoblasts after isoflurane but not propofol expo... by Frederik Abel (8452101)

    Published 2020
    “…Prior isoflurane exposure <i>in vitro</i> even increased protection (RIPC-EVs/control, apoptotic ratio: 0.79; p = 0.0035; Sham-EVs/control, apoptotic ratio:1.04) while propofol (50μM) abrogated protection by RIPC-EVs (RIPC-EVs/control, Apoptotic ratio: 1.01; Sham-EVs/control, apoptotic ratio: 0.94; p = 0.602). …”
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  15. 75
    Cytotoxicity (as of %Control) IC<sub>50</sub> value (mean ±SD in µM) of the tested compounds vs. Positive controls Cisplatin and doxorubicin against gastrointestinal and colorectal malignancies’ adherent monolayers.

    Cytotoxicity (as of %Control) IC<sub>50</sub> value (mean ±SD in µM) of the tested compounds vs. Positive controls Cisplatin and doxorubicin against gastrointestinal and colorectal... by MohammedBashar Al-Qazzan (22439236)

    Published 2025
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  16. 76
    Transforming Small-Molecule Nanoaggregation into Functional Drug Delivery Platforms

    Transforming Small-Molecule Nanoaggregation into Functional Drug Delivery Platforms by JunHyuk Kim (21235657)

    Published 2025
    “…The IC<sub>50</sub> value of <b>Nano-CC1-Acl</b> further decreases to 0.20 ± 0.16 μM in the presence of cysteine, a biothiol. …”
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  17. 77
    Transforming Small-Molecule Nanoaggregation into Functional Drug Delivery Platforms

    Transforming Small-Molecule Nanoaggregation into Functional Drug Delivery Platforms by JunHyuk Kim (21235657)

    Published 2025
    “…The IC<sub>50</sub> value of <b>Nano-CC1-Acl</b> further decreases to 0.20 ± 0.16 μM in the presence of cysteine, a biothiol. …”
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  18. 78
    Protein levels of Bcl-2 family markers in limbal stromal cells (LSCs) and in Aniridia-LSCs (AN-LSCs), after treatment with 0 µM, 50 µM and 75 µM Cobalt chloride (CoCl<sub>2</sub>), using flow cytometry (A-C).

    Protein levels of Bcl-2 family markers in limbal stromal cells (LSCs) and in Aniridia-LSCs (AN-LSCs), after treatment with 0 µM, 50 µM and 75 µM Cobalt chloride (CoCl<sub>2</sub>),... by Shanhe Liu (5251313)

    Published 2025
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  19. 79
    Preclinical Evaluation of <sup>131</sup>I/<sup>18</sup>F‑Labeled Covalent Small-Molecule Inhibitors for STING Status Imaging

    Preclinical Evaluation of <sup>131</sup>I/<sup>18</sup>F‑Labeled Covalent Small-Molecule Inhibitors for STING Status Imaging by Jianyang Fang (11301298)

    Published 2024
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  20. 80
    Preclinical Evaluation of <sup>131</sup>I/<sup>18</sup>F‑Labeled Covalent Small-Molecule Inhibitors for STING Status Imaging

    Preclinical Evaluation of <sup>131</sup>I/<sup>18</sup>F‑Labeled Covalent Small-Molecule Inhibitors for STING Status Imaging by Jianyang Fang (11301298)

    Published 2024
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