Synthesis, Biological Evaluation, Structure–Activity Relationship, and Mechanism of Action Studies of Quinoline–Metronidazole Derivatives Against Experimental Visceral Leishmaniasi... by Akanksha Upadhyay (6732857)

“…Among all synthesized derivatives, <b>15b</b> and <b>15i</b> showed significant antileishmanial efficacy against both extracellular promastigote (IC₅₀ 9.54 and 5.42 μM, respectively) and intracellular amastigote (IC₅₀ 9.81 and 3.75 μM, respectively) forms of Leishmania donovani with negligible cytotoxicity toward the host (J774 macrophages, Vero cells). …”

Sequence of <i>DpAP2</i> promoter. by Lingru Ruan (18995544)

“…<i>parva</i> cells treated with different concentrations of MeJA (10, 20, 50, 100 μM) and GA3 (10, 20, 50, 100 μM). The high concentrations of MeJA (10–100 μM) inhibited the accumulation of carotenoid, and the relative expression of <i>DpAP2</i>, <i>PSY</i>, <i>PDS</i> and <i>GGPS</i> decreased significantly. …”

Predicted <i>cis</i>-acting elements in <i>DpAP2</i> promoter. by Lingru Ruan (18995544)

“…<i>parva</i> cells treated with different concentrations of MeJA (10, 20, 50, 100 μM) and GA3 (10, 20, 50, 100 μM). The high concentrations of MeJA (10–100 μM) inhibited the accumulation of carotenoid, and the relative expression of <i>DpAP2</i>, <i>PSY</i>, <i>PDS</i> and <i>GGPS</i> decreased significantly. …”

One-way sensitivity analysis, <i>Immediate ART</i> strategy compared to <i>ART<350/μL</i>. by Eric N. Ouattara (6890174)

Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients - Fig 3 by Tomoyoshi Komiyama (474366)

“…B: Isoproterenol was decreased by 5 mM for each 1/10 at the following concentrations: 5 nM, 50 nM, 500 nM, 5 μM, 50 μM, 500 μM, and 5 mM. …”

Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells by Yang Li (7082)

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Zwitterion-Functionalized Cuprous Oxide Nanoparticles for Highly Specific and Enzymeless Electrochemical Creatinine Biosensing in Human Serum by R. K. Rakesh Kumar (14241205)

“…A linear response to creatinine concentration from 10 to 200 μM (<i>R</i>² = 0.9876 and LOD = 5.0 μM) was observed, which covers the entire range of physiological creatinine in human serum. …”

Developmental toxicity induced by 2 μg/ml propofol. by Yali Ge (417371)

Table_1_Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts.DOCX by Hong Zhang (25820)

“…However, EMPA did specifically decrease cardiac lactate labeling in the ¹³C glucose perfusions (¹³C labeling of lactate: 58 ± 2% vs. 50 ± 3%, for vehicle and EMPA, respectively; P = 0.02), without changes in other glucose metabolic pathways. …”

Effect of Safr and Cands on the levels of complex I (U/mg protein), complex II (U/mg protein), complex IV (U/mg protein), caspase-3 (Casp-3, μg/mg protein), Fas ligand (FasL, μg/mg... by Nagwa Ibrahim Shehata (17319689)

Discovery and Pharmacological Studies of 4‑Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis by José Ignacio Manzano (7908449)

“…We report the discovery of new 4-hydroxyphenyl phosphonium salt derivatives active in the submicromolar range (EC₅₀ from 0.04 to 0.28 μM, SI > 10) against the protozoan parasite Leishmania donovani. …”

ABT199 inhibits ALK ^mutant kinase activity and decreases it phosphorylation. by Richard Junior Zapata Dongo (17912565)

The PRAME-AS knockout cells showed a decrease in migration, proliferation, stemness, and viability. by Zahra Hosseininia (22265113)

Allele-specific PCR of <i>TMPRSS6</i> (rs1421312). by Osama M. Al-Amer (11707400)

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Genotype distribution of <i>TMPRSS6</i> (rs1421312) gene polymorphism with respect to clinical parameters. by Osama M. Al-Amer (11707400)

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Genotypes and allele frequencies of BMP2 (rs235756) polymorphism in normal subjects and in iron deficiency anemia group. by Osama M. Al-Amer (11707400)

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Genotype distribution of <i>BMP2</i> (rs235756) gene polymorphism with respect to clinical parameters. by Osama M. Al-Amer (11707400)

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Genotype distribution of <i>TMPRSS6</i> (rs1421312) gene polymorphism. by Osama M. Al-Amer (11707400)

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Genotypes and allele frequencies of TMPRSS6 (rs1421312) polymorphism in normal subjects and in iron deficiency anemia group. by Osama M. Al-Amer (11707400)

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ARMS-PCR of <i>BMP2</i> (rs235756). by Osama M. Al-Amer (11707400)

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