GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age. by Nicole K. Polinski (10947787)

“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”

Summary of subgroup analysis results. by Junyin Pan (20700411)

“…The results showed that dietary anthocyanins significantly improved various lipid and glycemic markers:</p><p>HDL-C: increased by 0.05 mmol/L (95% CI: 0.01 to 0.10, p = 0.026), LDL-C: decreased by 0.18 mmol/L (95% CI: -0.28 to -0.08, p = 0.000), Triglycerides (TGs): reduced by 0.11 mmol/L (95% CI: -0.20 to -0.02, p = 0.021), Total cholesterol (TC): lowered by 0.34 mmol/L (95% CI: -0.49 to -0.18, p = 0.000), Fasting blood glucose (FBG): reduced by 0.29 mmol/L (95% CI: -0.46 to -0.12, p = 0.001), Glycated hemoglobin (HbA1c): decreased by 0.43% (95% CI: -0.74 to -0.13, p = 0.005). …”

Original study data. by Junyin Pan (20700411)

“…The results showed that dietary anthocyanins significantly improved various lipid and glycemic markers:</p><p>HDL-C: increased by 0.05 mmol/L (95% CI: 0.01 to 0.10, p = 0.026), LDL-C: decreased by 0.18 mmol/L (95% CI: -0.28 to -0.08, p = 0.000), Triglycerides (TGs): reduced by 0.11 mmol/L (95% CI: -0.20 to -0.02, p = 0.021), Total cholesterol (TC): lowered by 0.34 mmol/L (95% CI: -0.49 to -0.18, p = 0.000), Fasting blood glucose (FBG): reduced by 0.29 mmol/L (95% CI: -0.46 to -0.12, p = 0.001), Glycated hemoglobin (HbA1c): decreased by 0.43% (95% CI: -0.74 to -0.13, p = 0.005). …”

S2 File - by Junyin Pan (20700411)

“…The results showed that dietary anthocyanins significantly improved various lipid and glycemic markers:</p><p>HDL-C: increased by 0.05 mmol/L (95% CI: 0.01 to 0.10, p = 0.026), LDL-C: decreased by 0.18 mmol/L (95% CI: -0.28 to -0.08, p = 0.000), Triglycerides (TGs): reduced by 0.11 mmol/L (95% CI: -0.20 to -0.02, p = 0.021), Total cholesterol (TC): lowered by 0.34 mmol/L (95% CI: -0.49 to -0.18, p = 0.000), Fasting blood glucose (FBG): reduced by 0.29 mmol/L (95% CI: -0.46 to -0.12, p = 0.001), Glycated hemoglobin (HbA1c): decreased by 0.43% (95% CI: -0.74 to -0.13, p = 0.005). …”

Forest plot. by Junyin Pan (20700411)

Funnel plot. by Junyin Pan (20700411)

Quantification of blood ACE levels in carriers of ACE mutations. by Olga V. Kryukova (19819428)

Microorganisms. by Lucas Romann (14803595)

Flowchart of the BCs included into this study. by Lucas Romann (14803595)

Comparison of choroidal measurements in vitreoretinal lymphoma (VRL) eyes and their fellow eyes. by Rae-Young Kim (11747549)

“…In the fellow eyes, the mean TCA was 0.94±0.37 in the active phase and 0.92±0.36 in remission (p = 0.128). (C) In VRL eyes, the mean SA was 0.32±0.08 in the active phase and 0.26±0.06 in remission (p = 0.025). …”

<b> </b> Energy efficiency and gas volume comparison. by Ning Zuo (17295415)

“…Kinetic model analysis showed that the activation energy for pyrolysis in the experimental group decreased from 145 kJ/mol at 400°C to 125 kJ/mol at 800°C, while the maximum methane yield in the Gompertz model increased from 405.026 mL at 400°C to 434.525 mL at 800°C in the experimental group. …”

Model validation of kinetic parameters. by Ning Zuo (17295415)

“…Kinetic model analysis showed that the activation energy for pyrolysis in the experimental group decreased from 145 kJ/mol at 400°C to 125 kJ/mol at 800°C, while the maximum methane yield in the Gompertz model increased from 405.026 mL at 400°C to 434.525 mL at 800°C in the experimental group. …”

Differential gene sets associated with the transcriptional host response to SARS-CoV-2 infection across serially collected samples. by Vasanthi Avadhanula (259546)

Discovery of Novel 3‑Phenylpiperidine Derivatives Targeting the β‑Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD‑1 Antibody for the Tre... by Hao Zhang (15339)

Discovery of Novel 3‑Phenylpiperidine Derivatives Targeting the β‑Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD‑1 Antibody for the Tre... by Hao Zhang (15339)

Discovery of Novel 3‑Phenylpiperidine Derivatives Targeting the β‑Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD‑1 Antibody for the Tre... by Hao Zhang (15339)

Discovery of Novel 3‑Phenylpiperidine Derivatives Targeting the β‑Catenin/B-Cell Lymphoma 9 Interaction as a Single Agent and in Combination with the Anti-PD‑1 Antibody for the Tre... by Hao Zhang (15339)

Actuating neuronal activity of Ssdp-expressing neurons alters autism-associated behaviors. by Safa Salim (9186786)

“…<i>P</i>-values are from a two-sided permutation <i>t</i> test. The raw data underlying panels 10B, C, E, and G can be found in S1 Data file. …”

<i>Ssdp</i> knockdown in Ssdp-Gal4 labeled cells partially rescues autism-associated behaviors. by Safa Salim (9186786)

“…(B) The active average speed of Ssdp^[2082-G4] /+ flies was similar to control flies (<i>n</i> = 46–47, Cliff’s Δ = 0.0014 [95 CI −0.235, 0.24], <i>p</i> = 0.99); however, Ssdp^[2082-G4] >UAS-Ssdp-RNAi flies moved slower in open field compared to w¹¹¹⁸ controls (<i>n</i> = 46–49, Cliff’s Δ = −0.48 [95 CI −0.667, −0.248], <i>p</i> < 0.0001) and Ssdp^[2082]/+ flies (<i>n</i> = 47–49, Cliff’s Δ = −0.59 [95 CI −0.755, −0.391], <i>p</i> < 0.0001). (C) Heterozygous Ssdp^[2082-G4] /+ flies show a significantly higher wall-following compared to controls (<i>n</i> = 49–57, Cliff’s Δ = 0.47 [95 CI 0.256, 0.651], <i>p</i> < 0.0001); however, Ssdp^[2082-G4]>UAS-Ssdp-RNAi flies show wall-following behavior similar to controls (<i>n</i> = 57–61, Cliff’s Δ = −0.031 [95 CI −0.246, 0.183], <i>p</i> = 0.78) and significantly decreased wall-following compared to Ssdp^[2082]/+ flies (<i>n</i> = 49–61, Cliff’s Δ = −0.62 [95 CI −0.768, −0.428], <i>p</i> < 0.0001). …”

Biochemical characterization of the endolysins of the lactococcal phages P008, c2, 1358, and P335. by Frank Oechslin (4825476)

“…<p>(<b>A)</b> The endolysin of phage P008 (LysP008) is composed of an amidase_2 CD that is known to hydrolyse the glycan–peptide linkage and a C-terminal region with homology to the CBD of the endolysin found in the <i>Enterococcus</i> phage IMEEF1 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001740#pbio.3001740.ref026" target="_blank">26</a>]. …”