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DCD is strikingly decreased in HS lesions.
Published 2019“…Co-staining was performed with K77 (green), which is a marker of eccrine sweat glands. Scale bar is 100μm. …”
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Repetitive stress induces a decrease in sound-evoked activity.
Published 2025“…These mice exhibited a minimal change in noise-evoked PPy activity when comparing the first and second week of imaging (2-way ANOVA, F = 1.79, <i>p</i> = 0.11, post hoc baseline w1 50 dB: baseline w2 50 dB <i>p</i> = 1 Bonferroni corrected, nested ANOVA (mouse nested within session) F = 1.76, <i>p</i> = 0.12, mean ± SE). …”
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The decrease or inhibition of Hsp90 induced REST degradation.
Published 2019“…(D) The level of REST dramatically reduced in differentiated SH-SY5Y cells treated with GA (1 μM) or PU-H71 (50 nM) at 24 h. (E) The REST level decreased by GA more than 50% and (F) PU-H71 more than 80%, respectively. …”
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AMPs are increased in lesional HS, but DCD and other sweat-gland associated proteins are decreased.
Published 2019“…<p>(A) Volcano plot showing increased or decreased genes in HS. Graph shows log FC in gene expression of HS lesional skin over HS non-lesional skin samples plotted against negative log p-value of the difference in gene expression. …”
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