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wt decrease » we decrease (Expand Search), nn decrease (Expand Search), awd decreased (Expand Search)
a decrease » _ decreased (Expand Search), _ decreases (Expand Search)
5 wt » _ wt (Expand Search), 5 ht (Expand Search)
wt decrease » we decrease (Expand Search), nn decrease (Expand Search), awd decreased (Expand Search)
a decrease » _ decreased (Expand Search), _ decreases (Expand Search)
5 wt » _ wt (Expand Search), 5 ht (Expand Search)
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Spatial training decreases endogenous PTEN ubiquitination and <i>Pten</i> cKO mice show impaired spatial learning and memory.
Published 2023“…Their CA1 tissue was subjected to western blot determination of PTEN expression, and the PTEN expression level is increased in trained rats (t<sub>1,10</sub> = 8.59, <i>p</i> < 0.001). N = 6 each group. <b>(D)</b> The <i>Pten loxp</i> mice (that received lenti-GFP vector transduction) and <i>Pten</i> cKO mice (that received lenti-GFP-2A-NLS-Cre vector transduction) were subjected to water maze learning two weeks after lentivirus transduction. …”
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Exposure to low CO<sub>2</sub> levels decreases ER cholesterol levels.
Published 2023“…<b>(B)</b> Bioluminescence recordings from the different conditions as depicted in <b>(A)</b>, the arrow indicates the time CO<sub>2</sub> was shifted from 5% to 1% (mean ± SE, <i>n</i> = 4 biological replicates per condition, AUC for 0 mM 0.34 ± 0.007, 1.59 ± 0.004 (<i>P</i> < 0.0001), 0.5 mM 1.00 ± 0.023, 2.68 ± 0.04 (<i>P</i> < 0.0001), 1 mM 1.66 ± 0.07, 3.34 ± 0.04 (<i>P</i> < 0.0001), 3 mM 2.06 ± 0.02, 2.79 ± 0.07 (<i>P</i> < 0.0001), 5 mM 2.02 ± 0.05, 2.43 ± 0.06 (<i>P</i> < 0.002), 7 mM 1.85 ± 0.01, 1.77 ± 0.02 (<i>P</i> < 0.02) two-sided Student’s <i>t</i> test). …”
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Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver.
Published 2021“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”
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The GluN2B-C456Y mutation decreases recombinant NMDAR currents and alters receptor properties.
Published 2020“…<i>n</i> = 73 oocytes for WT (5.70 ± 0.61 μA) and 59 oocytes for C456Y (0.039 ± 0.004 μA), ***<i>P</i> < 0.001, Mann-Whitney. …”
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