Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”

<b>Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decrease ISR activation in DRG neurons</b> by Muhammad Saad Yousuf (20745168)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

Effects of TGF-β1 on the expression of fibrosis indicators in HBdSMCs and the effects of MEL on the expression of fibrosis indicators in HBdSMCs induced by TGF-β1. by Yang Zhang (30734)

Antibodies used for flow cytometry experiments. by Joseph Rabin (7399436)

“…In separate mouse studies, subcutaneous RA infusion from Alzet minipumps at 1.44 μg/kg/h increased 10-day survival of SARS-CoV-2-infected K18-hACE2 mice from 10 to 40% (P<0.001).…”

Subject flow diagram. by Joseph Rabin (7399436)

“…In separate mouse studies, subcutaneous RA infusion from Alzet minipumps at 1.44 μg/kg/h increased 10-day survival of SARS-CoV-2-infected K18-hACE2 mice from 10 to 40% (P<0.001).…”

2‑Ethylhexyl Diphenyl Phosphate and Its Hydroxylated Metabolites are Anti-androgenic and Cause Adverse Reproductive Outcomes in Male Japanese Medaka (Oryzias latipes) by Yu Li (183836)

2‑Ethylhexyl Diphenyl Phosphate and Its Hydroxylated Metabolites are Anti-androgenic and Cause Adverse Reproductive Outcomes in Male Japanese Medaka (Oryzias latipes) by Yu Li (183836)

The pax7 probe set enables simultaneous detection of all three <i>pax7</i> genes. by Cécile Rallière (86527)

Inhibition of pan- and HDAC isoform activities. by Mira Jung (1277502)

Table_1_The Metabolic Changes and Immune Profiles in Patients With COVID-19.pdf by Bing He (135034)

“…In 32 mild COVID-19 patients, circulating monocytes were 0.45 × 10⁹/L (IQR, 0.36–0.64). Twenty-one severe patients had low PO₂ [57 mmHg (IQR, 50–73)] and SO₂ [90% (IQR, 86–93)] and high lactate dehydrogenase [580 U/L (IQR, 447–696)], cardiac troponin I [0.07 ng/mL (IQR, 0.02–0.30)], and pro-BNP [498 pg/mL (IQR, 241–1,726)]. …”

<i>S</i>. <i>pneumoniae</i> RNA regulators are ligand responsive and most designed mutations function as anticipated. by Indu Warrier (581139)

“…<p><b>(A)</b> β-galactosidase activity of RNA reporter strains grown in the absence and presence of ligand or ligand precursor (0.3 μg/mL thiamine, 140 ng/mL riboflavin, 20 μg/mL uracil, 75 μg/mL glycine, 204 μg/mL tryptophan, 50 μg/mL guanine) demonstrates regulation of gene expression with a significant difference between expression in the two conditions. …”

Image1_Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.TIF by Burong Feng (11661529)

Image2_Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.TIF by Burong Feng (11661529)

Image_1_RETRACTED: Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury: Impact on Myocardial Integrity.tif by Johanna Wall (8088959)

I-R-Polar-Negative-0902 by Sheng-Yuan Ho (16909464)

“…All analyses were conducted with a lockspray to guarantee precision and reproducibility. As the lockmass, we utilized leucine-enkephalin (m/z = 556.2771) at a concentration of 1 ng/L and a flow rate of 5 L/min. …”

Data_Sheet_1_Altered zinc homeostasis in a primary cell culture model of the retinal pigment epithelium.DOCX by Ana Álvarez-Barrios (15301603)

“…Zn cytoplasmic concentrations significantly decreased 0.2 times at 59 days, from 0.264 ± 0.119 ng·μg⁻¹ at 10 days to 0.062 ± 0.043 ng·μg⁻¹ at 59 days (p < 0.05). …”

Data_Sheet_1_Identification of novel small molecule inhibitors of twin arginine translocation (Tat) pathway and their effect on the control of Campylobacter jejuni in chickens.pdf by Loïc Deblais (5620073)

“…These selected eight Tat inhibitors cleared all tested Campylobacter strains (n = 12) at >10 ng/mL in the presence of 0.5 mM CuSO₄in vitro. …”