Effect of different doses of FA-SnO₂ NPs (50 mg/kg for group B, 100 mg/kg for group C and 200 mg/kg for group D) on biochemical profiling of the tested male Wistar rats... by Demiana H. Hanna (11512956)

Effect of different doses of FA-SnO₂ NPs (50 mg/kg for group B, 100 mg/kg for group C and 200 mg/kg for group D) on hematological parameters of the tested male Wistar ra... by Demiana H. Hanna (11512956)

Transient convection-diffusion of thrombin into and out of a fibrin domain exposed to venous flow. by Jason Chen (15937)

Reproduction number <i>R</i>(<i>t</i>) for the duration of the simulation. by Sebastian A. Müller (10688740)

Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor by Beatrice Noce (16540800)

Subjects:

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma by Zhihao Liu (419349)

“…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Taste sensilla in the wing and RNA-seq screen of control and <i>Poxn</i> wings. by Zhe He (508742)

Decreased echinocandin susceptibility in <i>Candida parapsilosis</i> causing candidemia and emergence of a pan-echinocandin resistant case in China by Yating Ning (11264310)

Transforming Small-Molecule Nanoaggregation into Functional Drug Delivery Platforms by JunHyuk Kim (21235657)

“…The IC₅₀ value of <b>Nano-CC1-Acl</b> further decreases to 0.20 ± 0.16 μM in the presence of cysteine, a biothiol. …”

Transforming Small-Molecule Nanoaggregation into Functional Drug Delivery Platforms by JunHyuk Kim (21235657)

“…The IC₅₀ value of <b>Nano-CC1-Acl</b> further decreases to 0.20 ± 0.16 μM in the presence of cysteine, a biothiol. …”

Variable importance plot (mean decrease accuracy and mean decrease Gini). by Fernando Martinez-Taboada (8655132)

miR-200c decreases KLOTHO expression in HK-2 cells by translational repression. by Kenichi Morii (6843554)

Competition localization increases with growth rate or the distances between colonies, and decreases with the resource diffusion constant. by Jeremy M. Chacón (8259792)

Excision of HIF1α decreases viral reactivation from latency in infected splenocytes in vivo. by Darlah M. López-Rodríguez (8098544)

Abolishing the ordered neuron density gradient decreased the positive correlation observed for axon elongation scaling. by Sarah F. Beul (6008801)

ROC curve and P-R curve (attack traffic proportion = 50%). by Longyan Ran (18452261)