Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”

Data_Sheet_1_Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction.PDF by José A. Hernández-Hermoso (11545663)

“…Mean sC2C levels (220.83 ± 39.50 ng/ml) decreased post-race (188.67 ± 38.52 ng/ml) (p = 0.002). …”

Description of the cohort (N = 118 patients). by Bastien Le Floc’h (14773916)

Correlation in average DNA methylation levels between TMS and EPIC data split by different subsets of the genome. by Amy Longtin (21409957)

Average and median coverage for on-target sites when mapped read files are subset to varying degrees. by Amy Longtin (21409957)

Table1_Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline.DOCX by Yangming Ding (8437077)

“…</p><p>Results: The in vitro f_m value indicated that the CYP3A4 pathway contributed more than 75% to BDQ metabolism to N-desmethyl-bedaquiline (M2), and TBI-166 was a moderate (IC₅₀ 2.65 µM) potential CYP3A4 inhibitor. …”

Homologs of 16p12.1 genes contribute towards neurodevelopmental defects through weak genetic interactions and combined independent effects. by Lucilla Pizzo (2735491)

DataSheet2_WNT5A Interacts With FZD5 and LRP5 to Regulate Proliferation and Self-Renewal of Endometrial Mesenchymal Stem-Like Cells.docx by Tianqi Li (1335987)

DataSheet1_WNT5A Interacts With FZD5 and LRP5 to Regulate Proliferation and Self-Renewal of Endometrial Mesenchymal Stem-Like Cells.docx by Tianqi Li (1335987)

DataSheet1_Different responses of soil element contents and their stoichiometry (C: N: P) to different grazing intensity on the Tibetan Plateau shrublands.docx by Xiuqing Nie (2633752)

Supplementary Material for: Ectopic ACTH-dependent Cushing’s syndrome Emerging at a Late Stage of a Mixed Histology Neuroendocrine Neoplasm: a case report by Meyers M. (19672471)

DataSheet1_Simultaneous silencing of juvenile hormone metabolism genes through RNAi interrupts metamorphosis in the cotton boll weevil.PDF by Daniel D. N. Vasquez (14721448)

Data_Sheet_1_Umbilical Cord Procalcitonin to Detect Early-Onset Sepsis in Newborns: A Promising Biomarker.docx by O. R. E. Dongen (11823293)

Age, body weight and ovarian function affect oocyte size and morphology in non-PCOS patients undergoing intracytoplasmic sperm injection (ICSI) by A. Weghofer (7541996)

Image_1_Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following... by Shardulendra Prasad Sherchand (13108779)

“…Therefore, we first optimized an in vitro assay that quantifies recombinant Gmd lysis of the M. luteus cell wall and used it to demonstrate the 50% neutralizing concentration (NC₅₀) of a humanized anti-Gmd mAb (TPH-101) to be ~15.6 μg/ml. …”

Image_3_Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following... by Shardulendra Prasad Sherchand (13108779)

“…Therefore, we first optimized an in vitro assay that quantifies recombinant Gmd lysis of the M. luteus cell wall and used it to demonstrate the 50% neutralizing concentration (NC₅₀) of a humanized anti-Gmd mAb (TPH-101) to be ~15.6 μg/ml. …”

Image_2_Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following... by Shardulendra Prasad Sherchand (13108779)

“…Therefore, we first optimized an in vitro assay that quantifies recombinant Gmd lysis of the M. luteus cell wall and used it to demonstrate the 50% neutralizing concentration (NC₅₀) of a humanized anti-Gmd mAb (TPH-101) to be ~15.6 μg/ml. …”

Table_1_Undercarboxylated Osteocalcin and Its Associations With Bone Mineral Density, Bone Turnover Markers, and Prevalence of Osteopenia and Osteoporosis in Chinese Population: A... by Yang Xu (178421)

“…The profile according to age showed that ucOC levels were the lowest at the age of 40–49 years in both men [2.55 ng/ml (95% CI = 1.96–3.13 ng/ml)] and women [1.57 ng/ml (95% CI = 1.12–2.03 ng/ml)]; in patients younger than 49 years, they decreased with age; then over 50 years, they quickly increased. …”

Image_1_Undercarboxylated Osteocalcin and Its Associations With Bone Mineral Density, Bone Turnover Markers, and Prevalence of Osteopenia and Osteoporosis in Chinese Population: A... by Yang Xu (178421)

“…The profile according to age showed that ucOC levels were the lowest at the age of 40–49 years in both men [2.55 ng/ml (95% CI = 1.96–3.13 ng/ml)] and women [1.57 ng/ml (95% CI = 1.12–2.03 ng/ml)]; in patients younger than 49 years, they decreased with age; then over 50 years, they quickly increased. …”