Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents حسب Marcian E. Van Dort (21374093)

الموضوعات:

The introduction of mutualisms into assembled communities increases their connectance and complexity while decreasing their richness. حسب Gui Araujo (22170819)

"…(C) Mutualism also promotes an increase in network connectance when introduced into assembled communities, while stopping mutualistic interactions from entering an assembled system slowly decreases it. …"

Crosslinking decreases the alignment of fibers associated with individual cells migrating out of spheroids. حسب Michael Pamonag (12295175)

KDM6A mRNA expression is decreased in PTFE mice. حسب Simon Lebek (9756148)

EQI decreases malonyl-CoA levels in <i>S</i>. <i>aureus</i>. حسب Erica C. Larson (1344687)

Expression of ApoB-50 decreased lipid accumulation and inhibited HCV production. حسب Bei Wang (116772)

VPS34 inhibition decreases intracellular levels of cholesteryl-esters, blocks cholesterol uptake and enhances lysosomal degradation of LDLR. حسب Marek J. Kobylarz (9292599)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

A randomized trial of a behavioral intervention to decrease hospital length of stay by decreasing bedrest حسب Juliana Tolles (8282265)

Primary endpoint analysis, i.e., time to first occurrence of combined event of 50% decrease in eGFR or ESRD. حسب Rozita Mohd (7411322)

Extracellular vesicles isolated from patients undergoing remote ischemic preconditioning decrease hypoxia-evoked apoptosis of cardiomyoblasts after isoflurane but not propofol expo... حسب Frederik Abel (8452101)

"…RIPC-EVs decreased H9c2 cell apoptosis compared to control (apoptotic ratio: 0.83; p = 0.0429) while Sham-EVs showed no protection (apoptotic ratio: 0.97). …"

The decrease in blood flow disrupts CV pruning. حسب Lin Wen (557398)

Data_Sheet_1_Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction.PDF حسب José A. Hernández-Hermoso (11545663)

"…Mean sC2C levels (220.83 ± 39.50 ng/ml) decreased post-race (188.67 ± 38.52 ng/ml) (p = 0.002). …"

Decreased expression levels of SPI-1 genes in <i>bipA</i>-deleted strain at 20°C. حسب Eunsil Choi (8271039)

الموضوعات:

Genes whose expression was decreased by 100 nM ouabain by more than 1.3-fold. حسب Larisa V. Smolyaninova (3600053)

Inhibition of PKCδ causes a decrease in viral replication. حسب Brian D. Carey (6092747)

Nicotine decreased Wnt5a expressions in SK-BR-3 cells. حسب Masanori A. Murayama (5774585)

Decreased biofilm formation in the Δ<i>tad123</i> mutant cells. حسب Tra-My Duong-Nu (7300970)

For each level of risk, we plot the proportion of respondents willing to seek vaccination across ages. حسب Bert Baumgaertner (3595814)