Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

“…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC₅₀ 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”

Construction of Enhanced Photostability Anthraquinone-Type Nanovesicles Based on a Novel Two-Step Supramolecular Assembly Strategy and Their Application on Multiband Laser-Responsi... by Linlin Su (570132)

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Construction of Enhanced Photostability Anthraquinone-Type Nanovesicles Based on a Novel Two-Step Supramolecular Assembly Strategy and Their Application on Multiband Laser-Responsi... by Linlin Su (570132)

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Graphical representation of a stepped-wedge design with 6 sequences. by Mirjam Moerbeek (8603520)

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E₅₀ values. by Junxia Zhou (14381598)

Schematic illustration of the possible steps for the rupture of a ‘single GUV’. by Md. Tariqul Islam Bhuiyan (18794375)

Fig 2 - by Min Sub Sim (8193564)

Different steps of the fabrication process. by Md. Abu Daud (21485629)

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. by Xiaowen Jiang (8291814)

Emerging Disinfection Byproduct 2,6-Dichlorobenzoquinone-Induced Cardiovascular Developmental Toxicity of Embryonic Zebrafish and Larvae: Imaging and Transcriptome Analysis by Xue Yang (144876)

“…Aromatic DBPs represent a significant portion of total DBPs, but their effects on cardiovascular development are unclear. In this study, we examined the effects of an aromatic DBP, 2,6-dichlorobenzoquinone (DCBQ), on the cardiovascular development of zebrafish embryos. …”

Effect of seed priming on anti-oxidants and lipid peroxidation in pearl millet at 50 DAS. by N. K. Gupta (11211399)

The fraction of predicted heterozygotes that are set to “No Call” by RHA decreases as the size of the heterozygote cluster increases. by Orna Mizrahi-Man (42539)

DataSheet_1_Hemizygous nonsense variant in the moesin gene (MSN) leads to a new autoimmune phenotype of Immunodeficiency 50.pdf by András L. Kovács (13565251)

“…We present a putative new autoimmune phenotype of Immunodeficiency 50 (MIM300988) characterized by antiphospholipid syndrome, Hashimoto’s thyroiditis, leg ulcers, and juvenile tooth loss, associated with W217X mutation of the MSN gene.…”

Shows the protein fragment of C3: The signal peptide and the alpha and beta chains, which consist of the C3a and C3b fragment. by Yonghui Wang (287491)

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Monomerization of Phthalocyanines in Water via Their Supramolecular Interactions with Cucurbiturils by Lucia Kociscakova (14334869)

“…Aggregation of phthalocyanines (Pcs) represents a problematic feature that decreases the potential of these macrocycles in a number of applications. …”

Simulations that now also include an <i>asymmetric</i> indoors/outdoors model, with a threshold temperature of 17.5C in spring, and 25C in fall. by Sebastian A. Müller (10688740)

STEP in-person sessions. by Shirley Yen (12632685)

“…Results from a pilot RCT demonstrated engagement of the target (positive affect) and a decrease in clinical outcomes (suicidal events; i.e., either a suicide attempt or an emergency intervention for an acute suicidal crisis), providing support to test the clinical effectiveness of STEP in a larger clinical trial with clinical staff implementing the intervention.…”

Comparison of mean differences in temperature decreases. by Hans-Jörg Gillmann (8460585)

Fluid loss and hydration in CON (n = 22) and HOT (n = 17) surgeries; Decrease in body mass in kg (A), decrease in body mass in % of total body mass (B), rate of decrease in body ma... by Zehra Palejwala (7507409)

Apoptosis inhibitor prevented the decrease of IIL ESP-induced TJs expression and alleviated barrier disruption of Caco-2 monolayer. by Qi Qi Lu (17721401)

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