Showing 141 - 160 results of 11,060 for search '(( 50 c decrease ) OR ((( 50 ng decrease ) OR ( 5 ((w decrease) OR (nn decrease)) ))))', query time: 0.50s Refine Results
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    First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

    Published 2022
    “…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC<sub>50</sub> value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC<sub>0‑inf</sub> (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”
  9. 149

    First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

    Published 2022
    “…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC<sub>50</sub> value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC<sub>0‑inf</sub> (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”
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    Solvent Entrapment of BI 763963 by Solid Solution Formation by Samruddhi Patil (11523791)

    Published 2025
    “…Ethanol (EtOH) and isopropanol (IPA) were entrapped in the crystal lattice of BI 763963 through solid solution formation, as demonstrated through a combination of experimental methods and structural analysis. Two binary T-w phase diagrams were constructed showing the outline of the solidus and liquidus, where EtOH and IPA are present in the solid phase of BI 763963 at 0.54 and 1.5 wt %, respectively, at equilibrium. …”