SARS-CoV‑2 Delta Variant Decreases Nanobody Binding and ACE2 Blocking Effectivity by Mert Golcuk (10789806)

SARS-CoV‑2 Delta Variant Decreases Nanobody Binding and ACE2 Blocking Effectivity by Mert Golcuk (10789806)

The Tenascin-C concentration and HIV-1 neutralizing potency of breast milk decreases over the postpartum period. by Robin G Mansour (2793226)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Purification of IgG anti-Ts5 antibodies. by Felipe Cerni (3477902)

Interferon-Based Therapy Decreases Risks of Hepatocellular Carcinoma and Complications of Cirrhosis in Chronic Hepatitis C Patients by Ching-Sheng Hsu (436554)

Silencing of Rap1A decreases ERK and p38 activation. by Yougen Wu (830191)

Non-linear effects of age on the log-odds of diabetes and hypertension (posterior means along with the 97.5% credible interval are shown). by Strong P. Marbaniang (10189860)

Chronic administration of propranolol decreases airway epithelial MUC5AC expression in rats exposed to CS. by Yujiao Zhou (573776)

Collagen V oral administration decreases inflammation and remodeling of synovial membrane in experimental arthritis - Fig 3 by Silvana Ramos Atayde (5571041)

“…The Suppl and IA/Suppl groups presented decreased Col V expression compared to the IA group in the synovial adjacent tissue (arrows) and synovial membrane (arrowhead). …”

Decreased total protein synthesis in muscle and increased amino acid concentrations in plasma in obese subjects. by Lee Tran (2106961)

Treatment with NaOH decreases ubiquitination of D_4.2R WT and D_{4.2 4KR}R mutant. by Kamila Skieterska (841014)

CXCL8 (2, 20, and 200 pg/ml) and CCL20 (5, 50, and 500 pg/ml) enhanced Ki-67 gene expression, but only 200 pg/ml of CXCL8 and 500 pg/ml of CCL20 enhanced early osteogenic marker ge... by Janak L. Pathak (759122)

(A) Procedural steps for minimally invasive Ponto surgery (MIPS). The MIPS procedure involves the following steps: (i) A circular incision is created at the selected site via a 4-... by Marsel Ganeyev (21453399)

Multivariable Linear Regression Model of the Residents P-V Fit score^a. by Yaotian Fan (5917766)

Subjects:

Population dynamics of <i>Killer-Rescue</i>/Cargo, <i>ClvR</i> and split^50cM <i>ClvR</i> V2. by Georg Oberhofer (3401438)

Propofol increased the number of the hippocampal pyramidal neurons and decreased the expression of the LC3-II protein and the number of lysosomes and autophagosomes in the ischemic... by Derong Cui (326839)

“…<p>I/R was induced by 2-vessel occlusion. Propofol 10, 50, or 100 mg/kg was administrated intraperitoneally and 3-MA (600 nM) was administered intracerebroventricularly 10 min after the onset of ischemia. (1) Sham-operated group (control group, Cont); (2) I/R group; (3) I/R+ 3-MA 600 nmol group; (4) I/R + propofol 10 mg/kg group; (5) I/R + propofol 50 mg/kg group; (6) I/R + propofol 100 mg/kg group; (7) I/R + vehicle (intralipid, 100 mg/kg) group. …”

related to Fig 5: Glycolysis critically regulates the acidification of phagosome and the assembly of v-ATPase complex. by Saray Gutiérrez (11473528)

Fig 5 - by Md Ehtashamul Haque (13020918)