Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss by Huixia Li (739049)

“…The trabecular bone volume of <i>Atg7</i> cKO mice was significantly lower than that of controls at 5 months of age. This phenotype was attributed to decreased osteoblast formation and matrix mineralization, accompanied with an increased osteoclast number and the extent of the bone surface covered by osteoclasts as well as an elevated secretion of <i>TNFSF11/RANKL</i> (tumor necrosis factor [ligand] superfamily, member 11), and a decrease in <i>TNFRSF11B/OPG</i> (tumor necrosis factor receptor superfamily, member 11b [osteoprotegerin]). …”

Change of liquid volume and pressure in the tank. by Liang Ge (541067)

“…The experimental results show that: (1) The liquid volume in a tank of vacuum degree within 2.0 Pa and 200 mm interlayer reduced no more than 15.5% after 48 days; (2) Taking the pressure in the tank as the power source, because of environmental differences inside and outside the pipe after 100 m pressure holding delivery, the physical form of liquid and gas could be converted instantly; (3) The continuous discharge time without ice blocking for a tank full of 2 m³ liquid was about 10.5 min under 25 L dual mode nitrogen pressurization, which is 1/12 of injection time after ground gasification; (4) Based on the temperature decrease trend measured at different positions, the cooling characteristics on liquid gasification jet path are quantified, and the calculation formula of temperature changing with time on the center line of liquid gasification jet is obtained. …”

Effect of changes in the amount of positive reinforcement of R and T. by Guillermo E. Delmas (6169820)

“…<p>(<b>A</b>) The rats were pre-trained by pay-off matrix [<i>P</i>_<i>R</i> = 1, <i>P</i>_<i>T</i> = 3, <i>P</i>_<i>P</i> = 4, <i>P</i>_<i>S</i> = 8 and contrast ] (filled dots) and the cooperation was strongly affected by change of temptation payoff, decreasing when T payoff increased and matrix with changed to [<i>R</i> = 1, <i>T</i> = 5, <i>P</i> = 4, <i>S</i> = 8 and contrast ] (open circles). …”

Deep Sequencing Analyses of Low Density Microbial Communities: Working at the Boundary of Accurate Microbiota Detection by Giske Biesbroek (104538)

“…With higher dilutions, low abundant species were overrepresented. In samples of <10⁵ bacteria per ml, <em>e.g.</em> DNA <1 pg/µl, microbiota profiling deviated from the original sample and other dilutions showing a significant increase in the taxa Proteobacteria and decrease in Bacteroidetes. …”

Structural definition of the full VRC01-class bnAb epitope in the context of the Env trimer. by Joseph G. Jardine (3075186)

“…Numbers in parentheses below each glycan name indicate the fold decrease in VRC01 IC₅₀ (i.e. increase in potency) upon substituting that glycan with an alanine. …”

The effect of sGP on immune response when antigen exposure mimics natural infection. by Gopi S. Mohan (111744)

“…<p>(A) Immunization study design. Female BALB/C mice were immunized IM with 50 µg of total DNA per immunization according to the schedule shown. …”

ScFv 2LF dissociation rate constants with each LF variant, measured by Biacore experiments. by Philippe Thullier (320909)

“…<p>The five residues whose mutation to alanine resulted in a 3-fold, or larger, decrease of the dissociation constant are shown in bold.…”

Rhesus macaque CD4 alleles are universally defective for HIV-1 entry. by Cody J. Warren (563898)

“…Genotype information was used to phase SNPs using Phase 2.1 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000304#pbio.3000304.ref081" target="_blank">81</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000304#pbio.3000304.ref082" target="_blank">82</a>] in DNAsp v5 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000304#pbio.3000304.ref083" target="_blank">83</a>]. …”

Effect of water activity and storage of tahini on the viability of stressed Salmonella serovars by Tareq OSAILI (10462496)

“…Tahini samples adjusted to aw values of 0.17, 0.35 and 0.50 were inoculated with a mixed culture containing 106-107 CFU/g of 4 serovars of unstressed, desiccation-or heat-stressed Salmonella and stored for up to 12 months at 10 and 25 °C. …”

Supplementary Material for: Human Oral Mucosal Stem Cells Reduce Anastomotic Leak in an Animal Model of Colonic Surgery by Kent I. (10699344)

“…The objective of this study was to evaluate whether hOMSC can decrease anastomotic leak rates in a murine model of colon surgery. …”

Phagocytosis activity and cytokine levels of macrophages differentiated from HL-60 cells. by Shuyan Chen (319209)

“…Quantification of the results (<b>C, D</b>). Decreased expression of TNF-α and IL-6 by 50–60% was found in the cell medium of CHEC-9 treated group (<b>E</b>). (** <i>p</i><0.005).…”

Influence of mentalis muscle relaxation on oronasal breathing by Mara Letícia Gobbis (10445129)

“…The mentalis muscle, in its turn, had in the pre- and post-phase, respectively, a mean (standard deviation) of 199.31 (279.77) µV and 114.58 (253.56) µV. …”

Impacts of Human Disturbance on Large Prey Species: Do Behavioral Reactions Translate to Fitness Consequences? by Mathieu Leblond (457233)

“…We hypothesized that human activities and infrastructure cause a decrease in the individual performance of preys because of anthropogenically enhanced predation risk. …”

M-cells are depleted with αRANKL antibody treatment. by Aimee L. Cunningham (650204)

“…<p>BALB/c mice (n = 3 per group) were treated i.p. with 250 μg of either rat Ig (a-b) or αRANKL antibody IK22-5 (c-d) on days 0, 2, 4, and 6. …”

Brazilian Women’s Health after 65 Years of Age by Angela Maggio da Fonseca (4717704)

“…Results The age of the patients on their first clinic visit ranged from65 to 98 years, with a mean age of 68.56 ± 4.47 years; their mean age at the time of natural menopause was 48.76 ± 5.07 years. …”

N-acetylcysteine Protects against Apoptosis through Modulation of Group I Metabotropic Glutamate Receptor Activity by Lili Sun (162122)

“…In this study, we investigated the effects of N-acetylcysteine (NAC), a precursor of the antioxidant glutathione, on group I mGlus activation in apoptosis of glial C6 and MN9D cell lines, and a rat model of Parkinson's disease (PD). …”

Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons by Matthew Dodson (4388749)

“…Finally, inhibition of autophagy initiation using 3-methyladenine (3MA) also results in a significant decrease in mitochondrial function and network length. …”

Heatmap comparing the metabolites extracted from feces of NOD mice at different times point pre- and post-vaccination using GC-MS. by Jacob Cobb (6400340)

“…The statistical significance was calculated using multiple paired <i>t</i> test with Benjamini, Kreiger, and Yekutiele corrected significance level indicated asterisks (*p < 0.05, **p<0.01, ***p<0.005, ****p<0.001). Red asterisks mean a significant increase and black asterisks mean a significant decrease in comparison to the pre-treated group. …”

Evaluation of Pelleting Mealworm (Tenebrio Molitor) Powder with Chokeberry By-product Meal To improve Duck Production and Meat Quality Traits by IH Choi (5838176)

“…<div><p>ABSTRACT This study aimed to evaluate the effects of dietary supplementation pelleted Tenebrio molitor (TM) powder with chokeberry by-product (CBP) meal on duck production and meat quality traits. A total of 180 0-day-old Pekin ducks were allocated randomly between three dietary groups viz., control, Treatment 1, and Treatment 2, with three pens per group and twenty birds per pen, characterized by increasing levels of pelleted TM powder with CBP meal in concentration of 0%, 1.5%, and 3%, respectively, and reared until 42 days of age in a completely randomized design. …”

Supplementary Material for: Evidence of an Acinar Response following Treatment for Exacerbation in Adult Patients with Cystic Fibrosis by Vanderhelst E. (4145263)

“…<b><i>Conclusions:</i></b> In CF patients in whom an improvement in LCI was obtained after treatment for an acute infectious exacerbation, this was paralleled by a decrease in acinar ventilation heterogeneity.…”