Minimum quorum sensing inhibitory concentrations (MQSICs), minimum inhibitory concentrations (MICs), and concentrations inhibiting 50% of violacein production (IC50s) of compounds... حسب Jean Paul Dzoyem (6424445)

الموضوعات:

Dose response of airways to Methacholine shows a decreased contractility in <i>GSTCD</i>^-/- mouse lungs following LPS treatment. حسب Bo Liu (127343)

Alternate Wetting and Drying Limits Arsenic in Porewater and Rice Grain under Severe Future Climate Conditions حسب Aria H. Duncan (22445853)

Population dynamics modeling of split^50cM <i>ClvR</i> V1 introduced at a 50% release, with fitness cost per allele varying from 0–15%. حسب Georg Oberhofer (3401438)

Neural networks classify states which differ in neuronal activity levels using ensembles of neurons that increase/decrease their activity in each state. حسب Nicholas A. Frost (10739821)

"…The hidden units have been ordered based on the output weights that are learned during classifier training. <b>(C)</b> After ordering the hidden units based on their output weight, we binned them into groups of 50. …"

Contribution of direct emissions, seed, compost, other field operations, irrigation, mineral fertilisers, pesticides and transport of inputs to the climate change impact of conserv... حسب Maria Vittoria Guidoboni (15852669)

Presentation_1_Airway macrophages display decreased expression of receptors mediating and regulating scavenging in early cystic fibrosis lung disease.pdf حسب Lisa J. M. Slimmen (16464600)

"…</p>Methods<p>Bronchoalveolar lavage fluid (BALF) was collected from 50 children with CF aged 1, 3 or 5 years. BALF cells were analyzed using flow cytometry. …"

Data from: Spillage and food dust do not decrease efficacy of long-lasting insecticide-incorporated netting against stored product insects حسب Sabita Ranabhat (17484660)

Kylo-0603’s EC50 & tissue levels. حسب Xueqin lu (22250795)

MBIC50 and MBEC50 values (µg/mL) of synthesized 1,2,3,5-tetrazine derivatives against bacteria pathogen strains. حسب Jean Paul Dzoyem (6424445)

الموضوعات:

Drive dynamics for split^<50cM <i>ClvR</i>s with different genetic linkage and migration rates. حسب Georg Oberhofer (3401438)

Oral administration of TVSE decreases angiogenesis in 4T1 tumors in BALB/c mice. حسب Hyun Sook Lee (8039876)

miR-200c decreases KLOTHO expression in HK-2 cells by translational repression. حسب Kenichi Morii (6843554)

Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor حسب Beatrice Noce (16540800)

"…We found that <b>9a</b>, bearing a pargyline moiety, is also able to selectively inhibit MAOB over MAOA (465-fold) with an IC₅₀ of 0.182 μM, being the first-in-class dual NOX2/MAOB covalent inhibitor. …"

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma حسب Zhihao Liu (419349)

"…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …"

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma حسب Zhihao Liu (419349)

"…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …"

Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma حسب Zhihao Liu (419349)

"…In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL-28-6 (<b>6</b>) exhibited increased activity against CARM1 while displaying decreased potency against other type I PRMTs. …"

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…In this study, we report the first highly selective HDAC6 inhibitor with hydrazide as the zinc-binding group (ZBG), which displays superior pharmacokinetic properties to the current hydroxamic acid inhibitors. …"

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

"…In this study, we report the first highly selective HDAC6 inhibitor with hydrazide as the zinc-binding group (ZBG), which displays superior pharmacokinetic properties to the current hydroxamic acid inhibitors. …"

Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer حسب Fan-Fan Shang (16953264)

"…Cucurbitacin B (CuB) is a potent but toxic anticancer natural product. Herein, we designed and synthesized 2-OH- and 16-OH-modified CuB derivatives to improve their antitumor efficacy and reduce toxicity. …"