Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents حسب Marcian E. Van Dort (21374093)

الموضوعات:

TBEV-induced translational arrest results in the decreased protein levels of GAPDH, HPRT1, and viperin. حسب Martin Selinger (3195987)

5-HT supplementation induces mitochondrial damage. حسب Li Gao (131516)

Decreases in muscle size, muscle force, and TB mass in 3-mo Lmna^HSA-cko mice. حسب Lei Xiong (334812)

(a) Schematic of the sample preparation, (b) developed GFRPs samples modified, (c) samples for impact strength tests, (d) samples for compressive strength tests. حسب Shaban Gul (14309526)

الموضوعات:

cIN accumulate in the ventrolateral cortex of <i>Emx1</i>-cKO mice. حسب Sathish Venkataramanappa (10331993)

Extracellular vesicles isolated from patients undergoing remote ischemic preconditioning decrease hypoxia-evoked apoptosis of cardiomyoblasts after isoflurane but not propofol expo... حسب Frederik Abel (8452101)

"…Hypoxia increased apoptosis of H9c2 cells (hypoxia: 8.4%±0.6; normoxia: 2.5%±0.1; p<0.0001). …"

Fig6B_modifiedSplitter_adjustTidalVolume_Patients_C_C_decrease: Variables for pair C-C, where the Tidal Volume of one patient was decreased by 30% whilst maintaining the other pati... حسب José A. Solís-Lemus (9272948)

<i>Ubr5</i>^<i>mt</i> synovium exhibits markers of increased canonical and decreased non-canonical HH signalling. حسب David Mellis (2833469)

Cell count data for Fig 5. حسب Zoey K. Wallis (17725175)

Silencing of RCC1L isoforms alter the levels of mitochondrial ribosomal proteins and biogenesis factors resulting in decreased mitochondrial translation. حسب Aurelio Reyes (412135)

Effects of 254- or 222-UVC exposure on <i>C</i>. <i>elegans</i> motility. حسب Kaoru Okamoto Yoshiyama (14526661)

JBPOS0101 decreased Amyloid Beta (Aβ) aggregates in the cortex and hippocampal regions in 5xFAD mouse brains. حسب Jihoon Jeong (4852690)

<i>Aspergillus flavus</i> mRNA expression (a) <i>aflD</i> and (c) <i>aflR</i> and phylogenetic analysis of (b) <i>aflD</i> and (d) <i>aflR</i> after exposure to 50 mg/mL of <i>U. e... حسب Martha Cebile Jobe (21175426)

Image_3_Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.tif حسب Nobuhiko Ebisutani (9764468)

"…A murine model of chronic social defeat stress (CSDS) was established by exposing a C57BL/6N intruder mouse to a CD-1 aggressor mouse for 3–5 min. …"

Image_2_Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.tif حسب Nobuhiko Ebisutani (9764468)

"…A murine model of chronic social defeat stress (CSDS) was established by exposing a C57BL/6N intruder mouse to a CD-1 aggressor mouse for 3–5 min. …"

Image_1_Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.TIF حسب Nobuhiko Ebisutani (9764468)

"…A murine model of chronic social defeat stress (CSDS) was established by exposing a C57BL/6N intruder mouse to a CD-1 aggressor mouse for 3–5 min. …"

Gap junction (GJ) communication decreases the proportion of cells exhibiting Ca²⁺ spikes. حسب Dharsan K. Soundarrajan (11632145)

Effects of 254- and 222-UVC exposure on <i>C</i>. <i>elegans</i> hatching rate. حسب Kaoru Okamoto Yoshiyama (14526661)