Effect of PEG-8000 on EGFR, cyclin D1 and p21 expression in SCC-25 cells-For these studies, western blot analysis was performed on lysates obtained from SCC-25 cell treated for 24... by Ramesh K. Wali (305603)

“…<p>As shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038047#pone-0038047-g005" target="_blank">Figure 5A</a>, consonant with the <i>in vivo</i> experiments PEG caused a significant decrease EGFR (∼45% compared to vehicle control; p<002) and cyclin D1 (∼57% compared to control vehicle; p<0.005) expression. …”

Transducer mechanisms activated by D1-like receptors. by Catalina Valdés-Baizabal (701863)

“…The use of H89 in the intracellular solution decreased the inhibitory effect of A-68930 from 29 ± 4% to 16 ± 5% at −10 mV (<i>P</i> = 0.08). …”

Evolutionary Consequences of Altered Atmospheric Oxygen in <em>Drosophila melanogaster</em> by Marc Charette (198776)

“…<div><p>Twelve replicate populations of <em>Drosophila melanogaster</em>, all derived from a common ancestor, were independently evolved for 34+ generations in one of three treatment environments of varying PO₂: hypoxia (5.0–10.1 kPa), normoxia (21.3 kPa), and hyperoxia (40.5 kPa). …”

Treatment of landfill leachate using Fenton Processes and Photo-Fenton Solar by Fábio Moraes da Costa (5376350)

“…These conditions led to a decrease in the toxicity of leachates' coefficient values to a degree equal to 50 % - for Aliivibrio fischeri greater than 50% - indicating a more suitable leachate for further biological treatment.…”

<i>Def6</i> RNA rescues the <i>def6</i> MO-induced phenotype. by Katerina Goudevenou (199855)

“…ANOVA single factor and two-tailed Student's <i>t</i>-tests showed a significant (p<0.001; three asterisks) increase in the angle after injection of 2.5 ng <i>def6</i> MO and a significant (p<0.001; three asterisks) decrease in the angle after addition of <i>def6</i> RNA. …”

X-ray solution scattering analysis indicating that fragmentation is radiation dose dependent. by Timothy R. Stachowski (9652625)

“…EndoH_CYS was irradiated at pH 7.5 and the results shown are averages of two replicates at a concentration of 5.0 mg/ml. …”

Evidence of decanalization. by Eric J. Hayden (307357)

“…UV absorbance was measured in 10 mM sodium cacodylate buffer (pH 7.5). The plot shows an example of the best-fit curve to data plotted as a derivative of the UV-absorbance (dA/dT) as a function of temperature (°C) for the <i>Azo*</i> (red) and wild-type (blue) ribozymes. …”

Profile of miRNA expression in asthmatic patients treated before and following treatment with budesonide. by Andrew E. Williams (262992)

“…Red indicates an increase in expression and green a decrease in expression relative to the mean expression of 227 miRNAs. …”

Gradual increase in the extent of γ-secretase saturation with its substrate leads to gradual changes from the biphasic to the standard dose-response curves. by Željko M. Svedružić (105215)

“…Further increase in the substrate (i.e. cDNAwtC99 >250 ng/mL) leads to decrease in Aβ 1–40 secretion (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050759#pone-0050759-t002" target="_blank">Table 2B</a>), which indicates that the substrate can also bind to the inhibition site (i.e. antagonism between complex <b><u>5</u></b> and complex <b><u>6</u></b>).…”

Supplemental Figure 1 by Chelsea Hutch (10156097)

Activation of the UPR can override the inhibition of NF-κB by IKK inhibitors in cancer cells with elevated IKK activity. by Arvin B. Tam (124164)

“…A reduction in P-IκBα and increase in total IκBα were seen corresponding to a decrease in IKK activity. …”

Riccardin D inhibited angiogenesis in intestinal polyps. by Hui-Ping Liu (290636)

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Figure bi demonstrates the increase in Rh123 fluorescence at 1 minute, 6 minutes and 12 minutes that reflects mitochondrial membrane depolarisation in PINK1 ko cells. c, d: Single cell traces of PINK1 ko neurons demonstrating that dopamine induced decrease in ΔΨ_m occurs independently of any change in [Ca²⁺]_c in some cells (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1c</a>), whereas in other cells dopamine induced decrease in ΔΨ_m co-incides with a rise in [Ca²⁺]_c (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1d</a>). e: Incubation with D1/D5 receptor antagonist SCH23390 (20 µM) did not alter the dopamine induced calcium signal or mitochondrial depolarisation in PINK1 ko neurons. f: Dopamine induced mitochondrial depolarisation was prevented by application of the PTP inhibitor 1 µM cyclosporine A.…”

Elimination testing with adapted scoring reduces guessing and anxiety in multiple-choice assessments, but does not increase grade average in comparison with negative marking by Jef Vanderoost (5108072)

“…The comparison is structured around seven hypotheses: in comparison with negative marking, elimination testing with adapted scoring leads to (1) a similar average score (no grade inflation); (2) students expressing their partial knowledge; (3) a decrease in the number of blank answers; (4) no gender bias in the number of blank answers; (5) a reduction in guessing; (6) a decrease in self-reported test anxiety; and finally (7) students preferring elimination testing with adapted scoring over negative marking.…”

Calcareous nannofossil biostratigraphy of the Late Cretaceous‒early Paleocene interval in the Zagros basin (southeastern Tethys), Iran by Azam Mahanipour (10126937)

“…This study concentrates on two sections (the Gurpi and Kabir-Kuh sections) in the west and southwest of Iran in the Zagros Basin, which span biozones CC25c/UC20bTP to NP6/NTp10B in the Kabir-Kuh and CC25b/UC20aTP to NP5/NTp9 in the Gurpi section. Late Maastrichtian nannofossil abundance and diversity in the studied intervals is high with a sharp decrease slightly above the K/Pg boundary. …”

Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability-0 by Andreas Peth (85734)

“…Whereas the anti-CSN5 antibody revealed a reduction to 23% as compared to the control, there was no decrease of the CSN complex observed with the anti-CSN8 antibody. …”

Table_1_Trends in the Utilization of Teleneurology and Other Healthcare Resources Prior to and During the COVID-19 Pandemic in an Urban, Tertiary Health System.pdf by Benjamin R. Kummer (9743116)

“…Older age (aOR 0.98, 97.5%CI 0.98–0.99), female sex (aOR 0.90 97.5%CI 0.83–0.99), and Medicaid insurance (aOR 0.78, 0.68–0.90) were associated with decreased odds of loss to follow-up.…”

Ras transformation affects the circadian clock via MAPK signalling. by Angela Relógio (193817)

“…(<b>B</b>) Western Blot analysis of RAS protein expression for the HaCaT cell lines and its derivatives (HaCaTI7, HaCaTII4, A5RT3), shows clear RAS overexpression measured in A5RT3. …”

Behavioral Logic for Operant Training and Discrimination Testing by Samar B Mehta (274037)

“…As this behavior was established, <i>N</i> was increased from 0.063 s to 1.5 s.</p> <p>(C) Stimulus training. All trials in this stage were initiated by a 1.5-s nose poke. …”

Low Health System Performance, Indigenous Status and Antivenom Underdosage Correlate with Spider Envenoming Severity in the Remote Brazilian Amazon by Vanderson Souza Sampaio (3167037)

“…Envenomings recorded from urban areas [Odds ratio (OR) = 0.40 (95%CI = 0.30–0.71; p<0.001)] and living in a municipality with a mean health system performance index (MHSPI >median [OR = 0.64 (95%CI = 0.39–0.75; p<0.001)] were independently associated with decreased risk of severity. …”