يعرض 141 - 160 نتائج من 64,878 نتيجة بحث عن '(( 50 mg decrease ) OR ( 5 ((((nm decrease) OR (a decrease))) OR (nn decrease)) ))', وقت الاستعلام: 0.83s تنقيح النتائج
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    Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects حسب Xiaopeng Peng (9136955)

    منشور في 2022
    "…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC<sub>50</sub> = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC<sub>50</sub> of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC<sub>50</sub> of 65 and 126 nM, respectively). …"
  3. 143

    Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects حسب Xiaopeng Peng (9136955)

    منشور في 2022
    "…The most potent compound <b>NT-6</b> exhibited high tubulin polymerization inhibitory activity (IC<sub>50</sub> = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC<sub>50</sub> of 30 nM, better than colchicine and the hit compound <b>1f</b> (IC<sub>50</sub> of 65 and 126 nM, respectively). …"
  4. 144

    Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

    منشور في 2021
    "…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
  5. 145

    Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

    منشور في 2021
    "…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
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    Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses حسب Jing Wang (6206297)

    منشور في 2025
    "…However, how global land use changes impact soil N supply and potential N loss remains elusive. By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …"
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