Effects of a clinical medication review focused on personal goals, quality of life, and health problems in older persons with polypharmacy: A randomised controlled trial (DREAMeR-s... by Sanne Verdoorn (6680822)

“…Over 6 months, in the intervention group, HR-QoL measured with EQ-VAS increased by 3.4 points (95% confidence interval [CI] 0.94 to 5.8; <i>p</i> = 0.006), and the number of health problems with impact on daily life decreased by 12% (difference at 6 months −0.34; 95% CI −0.62 to −0.044; <i>p</i> = 0.024) as compared with the control group. …”

Overexpression of tau inhibited whole-cell currents through Kv channels. by Xiantao Li (683919)

“…<p>(A) The outward Kv currents were evoked by stepped up to +60 mV for 500 ms at a holding potential of -80 mV in N2A cells. …”

Abundance-interaction atemporal pattern and distribution of species interactions for competitive and cooperative species. by Jie Li (15030)

Strain-Insensitive, Crosstalk-Suppressed, Ultrawide-Linearity Iontronic Tactile Skin from a Synergistic Segment-Embedded Strategy by Yanchao Zhao (5129174)

Strain-Insensitive, Crosstalk-Suppressed, Ultrawide-Linearity Iontronic Tactile Skin from a Synergistic Segment-Embedded Strategy by Yanchao Zhao (5129174)

Changes in ELF5, FOXA1 and ER binding to the genome are reflected in gene expression. by Catherine L. Piggin (8212272)

“…Panel <b>B</b>, as for panel A but showing genes for which FOXA1 or ER binding was increased or decreased by induction of ELF5. …”

ELF5 transcriptional effects measured by RNA-seq. by Catherine L. Piggin (8212272)

“…<p>Panel <b>A</b>, GO ontologies enriched in the RNA-seq data set by induction of ELF5, font size relative to enrichment score. …”

The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor by Elizabeth A. Coe (8195508)

“…<i>DIRC3</i> is a nuclear lncRNA that activates expression of its neighbouring <i>IGFBP5</i> tumour suppressor through modulating chromatin structure and suppressing SOX10 binding to putative regulatory elements within the <i>DIRC3</i> locus. …”

Reaction force vs. 5 µm displacement of the indenter. by Shreyas S. Rao (170163)

“…<p>Insert illustrates a decrease in stiffness with increasing Matrigel height due to a 5 µm indenter displacement. …”

Disruption of the viral cyclin has no effect on the frequency of viral genome positive cells yet results in a reduced frequency of LANA::βla+ cells. by Brian F. Niemeyer (11707995)

ADAR1 binding affinity at inferred A-to-I RNA editing candidate sites. by Xinxin Peng (219357)

Functional validation of a miRNA-34a-TREM2–3’UTR interaction. by Surjyadipta Bhattacharjee (3181674)

“…<p><b>(A)</b> ribonucleotide sequence of the 299 nt TREM2-mRNA-3’-UTR is shown in the 5’-3’ direction; the 22 nt miRNA-34a-TREM2 3’UTR complementarity-interaction region is indicated by a black underline and the 8 nt TREM2-mRNA-3’-UTR seed sequence <b>5’-ACACUGCU-3’</b> is overlaid in yellow; a single arrowhead indicates the 5’ end of a poly A+ tail in the TREM2 mRNA (22 ‘A’ nt shown; the length of this poly A+ tail is variable); TREM2 mRNA sequence derived from NM_018965; TREM2 transcript is the major X1 variant (see also <a href="http://switchdb.switchgeargenomics.com/productinfo/id_801321/" target="_blank">http://switchdb.switchgeargenomics.com/productinfo/id_801321/</a>) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a></b>); <b>(B)</b> TREM2-mRNA-3’UTR expression vector luciferase reporter assay (pLightSwitch-3’UTR; Cat#S801178; Switchgear Genomics, Palo Alto CA); in this vector, the entire 299 nucleotide TREM2 3’UTR was ligated into the unique Nhe1-Xho1 site; <b>(C)</b> control C8B4 murine microglial cells, 1 week in culture; phase contrast bright field microscopy 20x; C8B4 cells transfected with the TREM2-mRNA-3’UTR expression vector luciferase reporter were treated exogenously with miRNA-34a, a scrambled control miRNA-34a (miRNA-sc) or control miRNA-183; see references and text for further details [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref018" target="_blank">18</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref019" target="_blank">19</a>]; <b>(D)</b> compared to control, C8B4 cells transfected with a scrambled (<b>sc</b>) control pLightSwitch-3’UTR vector, the TREM2-mRNA-3‘UTR vector exhibited decreased luciferase signal to a mean of 0.16-fold of controls in the presence of miRNA-34a; this same vector exhibited no change in the presence of the control miRNA-34a-sc or miRNA-183; for each experiment (using different batches of MG cells) a control luciferase signal was generated and included separate appropriate controls with each analysis; in addition a control vector β-actin-3’UTR showed no significant effects on the relative luciferase signal yield after treatment with either miRNA-183 or miRNA-34a (data not shown); dashed horizontal line set to 1.0 for ease of comparison; N = 5; *<i>p</i><0.001 (ANOVA). …”

Interventions for Psychological Stress in Pregnant African American Women: A Scoping Review by Taleah A. Frazier (22423294)

Additional <i>Setd5</i> behavioural controls. by Laura E. Burnett (18794525)

“…<b>(A</b>) Average speed during prestimulus exploration (<i>Setd5</i>^+/+, 7.50 cm s⁻¹; <i>Setd5</i>^+/−, 6.65 cm s⁻¹, <i>P</i> = 0.151). …”

Model comparison for different theories for the mouse germline bottleneck. by David M. Edwards (10692265)

Determination of 4.5SI RNA half-life. by Anastasia P. Koval (137050)

“…<p>(<b>A</b>) Northern hybridization of 4.5SI RNA and 5S rRNA in total RNA isolated from KAC cells exposed to actinomycin D for different time periods. …”

The influence of positional release therapy on the myofascial tension of the upper trapezius muscle by Francisco José Saavedra (4904293)

“…A significant decrease in painful symptoms from 5.3 ± 1.9 to 2.8 ± 1.8 (p < 0.001) was observed after treatment. …”

JHMV replicates poorly in the brains of IFN-γ and IFN-γR null mice. by Catherine M. Kerr (21492574)

Heatmap of the members of the Wnt clusters identified by the five methods. by Mary-Lee Dequéant (271208)

bpV(pic) reduces neuronal autophagosome aggregation. by Chandler L. Walker (188845)

“…<p>Vehicle-treated rats exhibited dense intracellular LC3-positive autophagosome aggregation in neurons (arrows). Treatment with bpV promoted a decrease in neuronal autophagosome clustering. …”