An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing by Raymond W. Wong (8463498)

“…<div><p>The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing—a segment of the viral lifecycle not targeted by current drugs—and discovered compound N-[4-chloro-3-(trifluoromethyl)phenyl]-7-nitro-2,1,3-benzoxadiazol-4-amine (5342191) as a potent inhibitor of both wild-type (<i>Ba-L</i>, <i>NL4-3</i>, <i>LAI</i>, <i>IIIB</i>, and <i>N54</i>) and drug-resistant strains of HIV-1 (IC₅₀: ~700 nM) with no significant effect on cell viability at doses tested. 5342191 blocks expression of four essential HIV-1 structural and regulatory proteins (Gag, Env, Tat, and Rev) without affecting total protein synthesis of the cell. …”

Figure S1-S21 from miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5 by Verena Stiegelbauer (4582930)

“…(A-B) In cohort 1, miR-196b-5p expression decreased with (A) higher tumor stage, whereas no difference could be observed for (B) tumor grade. …”

Loss of <i>nowl</i> in the nervous system causes sleep fragmentation. by Gianna W. Maurer (6103637)

“…(H) Sleep pattern of <i>Neurofibromin-1</i> (<i>Nf1</i>) knockdown males under a 12-hour light/dark (white and black bars) cycle in 30-minute intervals shows effects on sleep compared to controls (<i>elav>+</i> and <i>Nf1-RNAi/+</i>) similar to animals lacking <i>nowl</i>, with decreased sleep mainly during the night. Graphs represent means with SEM (n = 32–92) of data pooled from one to three independent experiments. …”

Frequency-dependent activation in NF trabeculae (<i>n</i> = 9) vs. failing trabeculae with no hypothyroidism (FNH; <i>n</i> = 9) and failing trabeculae with hypothyroidism (FH; <i>... by Nancy S. Saad (2615341)

“…<b>(D)</b> TTP shortened upon increasing frequency of stimulation in all groups with no differences between NF and both failing groups at each respective frequency. <b>(E)</b> RT50 decreased as frequency increased from 0.5 Hz to 3 Hz in all three groups. …”

Metadata record for the article: The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers by Leticia De Mattos-Arruda (3933068)

“…Patient tumour-infiltrating lymphocytes data are contained in the file ‘Patient_TILsMeans_PAM50_ORR_HR_status_Neoprep_Maf.csv’. These files are not publicly available for the following reason: data contain information that could compromise research participant privacy. …”

Length-dependent activation in NF trabeculae (<i>n</i> = 9) vs. failing trabeculae with no hypothyroidism (FNH; <i>n</i> = 9) and failing trabeculae with hypothyroidism (FH; <i>n</... by Nancy S. Saad (2615341)

“…<b>(D)</b> TTP in NF myocardium was markedly slowed down as muscle length increased rather than the two failing groups, while trabeculae isolated from FNH hearts showed a prolonged TTP overall different muscle lengths compered to both NF and FH hearts and became significantly different compared to NF at L₈₅ (<i>P</i> = 0.013) and L₉₀ (<i>P</i> = 0.032). <b>(E)</b> RT50 decreased as muscles were shortened from L₁₀₀ to L₈₅ and the degree of shortening was much obvious in NF group. …”

Sound evoked cortical activity across vigilance states before and after NOE. by Linus Milinski (10532121)

“…Sounds were one octave narrow band noise (NBN) bursts centred at 1, 4, 8, and 16 kHz, at a stimulus level of 40, 50, 60, and 65 dB SPL, with a duration of 820 ms that included a silent gap of 38 ms. …”

Presentation_1_Translation suppression underlies the restrained COVID-19 mRNA vaccine response in the high-risk immunocompromised group.pptx by Kangsan Kim (4570987)

“…Selective use of tacrolimus or drug holiday of sirolimus can be a potential means to rescue translation-dependent Sp protein production. …”

S1 Data - by Dénes Pauka (16955686)

“…Comparing the histological groups by the measured parameters (<i>F</i>_max, <i>L</i>_max, <i>F</i>_break, <i>L</i>_break) showed a significant difference in the means (p<0.001, p = 0.003, p<0.001 respectively). …”

Phenotypic characterization of <i>CsIVP</i>-RNAi transgenic plants. by Shuangshuang Yan (798064)

“…(I) Reduced mature fruit length and decreased seed viability in the <i>CsIVP</i>-RNAi lines. …”

Data_Sheet_1_The effect of Ba Duan Jin exercise intervention on cardiovascular disease: a meta-analysis of randomized controlled trials.PDF by Jiali Chen (5696)

“…Subgroup analyses reveal that Ba Duan Jin exercise therapy decreases SBP (MD = −4.05, 95% CI = −6.84 to −1.26, p < 0.01) and DBP (MD = −3.21, 95% CI = −5.22 to −1.20, p < 0.01) levels in patients with essential hypertension, significantly reduces serum TC (MD = −0.78, 95% CI = −1.06 to −0.50, p < 0.01), TG (MD = −0.78, 95% CI = −0.93 to −0.62, p < 0.01), and LDL-C (MD = −0.76, 95% CI = −0.92 to −0.60, p < 0.01) levels in patients with hyperlipidemia, increases HDL-C (MD = 0.32, 95% CI = 0.14–0.51, p < 0.01) levels, and produces beneficial effects on cardiovascular function. …”

UPPAAL SMC model specification by Marc Souvannasouck (16475829)

“…</li> <li>The Light and Serious locations are marked as urgent, which in UPPAAL means that time can't progress in these states, leading to immediate transitions to other states.…”