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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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apoA2 correlates to gestational age with decreased apolipoproteins A2, C1, C3 and E in gestational diabetes
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">Apoproteins apoA2, apoC1, apoC3 and apoE are decreased in women with GDM and may have a role in inflammation, as apoA2 and C3 correlated with CRP. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…This may be achieved by decreasing protein glycation by the reactive metabolite, methylglyoxal (MG). …”
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Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer
Published 2025“…Silencing LDHC in breast cancer cell lines (MDA-MB-468, BT-549, HCC-1954) enhanced early T cell activation and cytolytic activity. …”
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miRNA-dependent regulation of STIM1 expression in breast cancer
Published 2019“…<p dir="ltr">Store-operated Ca<sup>2+</sup> entry (SOCE) has been shown to be important for breast cancer metastasis in xenograft mouse models. …”
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Characterizing the Protein Coding RNAs (mRNA) and Long Non-Coding RNAs (LncRNAs) in Chemo Resistant Triple Negative Breast Cancer
Published 2023“…Although, death rates due to BC have consistently decreased over time, TNBC still poses a challenge due to its poor prognosis, high rates of relapse and resistance to chemotherapy. …”
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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
Published 2023“…Our results show that induction of SLFN11 expression can enhance DDA and DDR sensitivity in breast cancer cells and dCas9 systems may represent a novel approach to increase SLFN11 and achieve higher sensitivity to chemotherapeutic agents, improving outcome or decreasing required drug concentrations. …”
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eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways
Published 2018“…These effects are likely dependent on the inhibition of eIF4A activity since we observed similar results using PatA. …”
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Identification of genetic determinants of breast cancer immune phenotypes by integrative genome-scale analysis
Published 2017“…These findings suggest that mutation-driven perturbations of MAPK pathways are linked to the negative regulation of intratumoral immune response in breast cancer. Modulations of MAPK pathways could be experimentally tested to enhance breast cancer immune sensitivity.…”
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Anabolic steroids-induced delirium
Published 2020“…Psychiatric aspects are of particular importance and include psychosis, delirium, mania, depression, and aggression. We describe the case of a young gentleman who was managed as a case of androgenic steroid induced delirium.…”
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
Published 2020“…In the mouse model, R. coriaria at a higher dose (1%) significantly decreased tumor volume by 27% when compared to controls. …”
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Exploring the LDHC Interactome as Novel Candidate Therapeutic Targets to Advance Breast Cancer Precision Medicine
Published 2024“…</p><p dir="ltr">Finally, silencing of <i>PKM2 </i>and<i> TUBA1B</i> in breast cancer cells increased DNA damage and decreased cancer cell survival, validating their role in genomic integrity and mimicking our previous observations following silencing of LDHC. …”
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Meta-Heuristic Algorithm-Tuned Neural Network for Breast Cancer Diagnosis Using Ultrasound Images
Published 2022“…<div><p>Breast cancer is the most menacing cancer among all types of cancer in women around the globe. …”
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CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion
Published 2017“…While the exact function of CD146 in breast cancer (BC) is not completely understood, substantial evidence from our work and others support the hypothesis that CD146 is a suppressor of breast tumor progression. …”
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Acute spasticity in malignant MCA stroke: a case report and review of literature
Published 2025“…However, an acute onset of spasticity at presentation is extremely rare. We report a case of a 40-year-old male patient who presented with spasticity accompanied by aphasia and decreased consciousness. …”
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Predictors of mortality and morbidity in critically ill COVID‐19 patients: An experience from a low mortality country
Published 2022“…<h3>Background and Aims</h3><p dir="ltr">Clinical characteristics and factors associated with mortality in patients admitted to the intensive care unit (ICU) in countries with low case fatality rates (CFR) are unknown. We sought to determine these in a large cohort of critically ill COVID-19 patients in Qatar and explore the early mortality predictors. …”
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Old subjects with sepsis in the emergency department: trend analysis of case fatality rate
Published 2019“…<h3>Background</h3><p dir="ltr">The burden of sepsis represents a global health care problem. We aimed to assess the case fatality rate (CFR) and its predictors in subjects with sepsis admitted to a general Italian hospital from 2009 to 2016, stratified by risk score.…”
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